SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tbf TRANSLATION
ELONGATION FACTOR
(Vibrio
cholerae) 		5 / 11 PHE A 233
PHE A 366
PHE A 293
LEU A 189
VAL A 223
 None
 1.30A 1q23L-5tbfA:
undetectable		 1q23L-5tbfA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5tbf TRANSLATION
ELONGATION FACTOR
(Vibrio
cholerae) 		3 / 3 SER A 206
GLY A 207
ARG A 301
 None
 0.58A 1t9wA-5tbfA:
2.3		 1t9wA-5tbfA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5tbf TRANSLATION
ELONGATION FACTOR
(Vibrio
cholerae) 		4 / 7 ILE A 281
LEU A 371
THR A 236
THR A 375
 None
 1.10A 3nxuA-5tbfA:
undetectable		 3nxuA-5tbfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 5tbf TRANSLATION
ELONGATION FACTOR
(Vibrio
cholerae) 		4 / 5 GLY A 183
TRP A 181
ALA A 182
PHE A 363
 None
 1.42A 3wqwA-5tbfA:
undetectable		 3wqwA-5tbfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5tbf TRANSLATION
ELONGATION FACTOR
(Vibrio
cholerae) 		5 / 12 LEU A 268
ILE A 262
ASP A 279
LEU A 371
ALA A 231
 None
 1.09A 5h5fA-5tbfA:
undetectable		 5h5fA-5tbfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5tbf TRANSLATION
ELONGATION FACTOR
(Vibrio
cholerae) 		3 / 3 VAL A 446
TYR A 458
GLN A 459
 None
 0.75A 5qgrA-5tbfA:
undetectable		 5qgrA-5tbfA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 5tbf TRANSLATION
ELONGATION FACTOR
(Vibrio
cholerae) 		4 / 7 THR A 258
LEU A 347
ILE A 323
THR A 322
 None
 1.00A 5zsfA-5tbfA:
undetectable
5zsfB-5tbfA:
undetectable		 5zsfA-5tbfA:
12.62
5zsfB-5tbfA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5tbf TRANSLATION
ELONGATION FACTOR
(Vibrio
cholerae) 		3 / 3 ARG A 407
LYS A 404
ARG A 390
 None
 1.14A 6c06D-5tbfA:
undetectable		 6c06D-5tbfA:
undetectable