SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		3 / 3 TRP A 390
VAL A 347
TRP A 348
 None
 1.31A 1gmkC-5tbkA:
undetectable
1gmkD-5tbkA:
undetectable		 1gmkC-5tbkA:
8.05
1gmkD-5tbkA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 10 LEU A 420
ALA A 477
ILE A 480
LEU A 439
PHE A 485
 None
 1.19A 3fl9A-5tbkA:
undetectable		 3fl9A-5tbkA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 10 LEU A 369
ALA A 346
GLY A 309
VAL A 364
LEU A 350
 None
 1.28A 3ogpB-5tbkA:
undetectable		 3ogpB-5tbkA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 ILE A 342
HIS A 295
GLN A 301
ALA A 304
LEU A 305
 None
 1.04A 3ozwB-5tbkA:
undetectable		 3ozwB-5tbkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		4 / 7 ILE A 251
LEU A 259
ALA A 304
ALA A 303
 None
 0.88A 3r9tB-5tbkA:
undetectable		 3r9tB-5tbkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		4 / 5 GLY A 182
TRP A 179
ALA A 180
PHE A 216
 None
 1.38A 3wqwA-5tbkA:
undetectable		 3wqwA-5tbkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		4 / 6 ILE A 462
ILE A 413
PHE A 485
LEU A 439
 None
 0.98A 4m51A-5tbkA:
undetectable		 4m51A-5tbkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 LEU A 166
LEU A 181
ASN A 183
THR A 150
ALA A 136
 None
 1.06A 4x1kA-5tbkA:
undetectable
4x1kB-5tbkA:
undetectable		 4x1kA-5tbkA:
23.25
4x1kB-5tbkA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		4 / 4 LEU A 205
ILE A 208
PRO A 245
LEU A 247
 None
 1.19A 5eb3A-5tbkA:
undetectable		 5eb3A-5tbkA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		4 / 5 ALA A 158
VAL A 153
PHE A 162
ILE A 142
 None
 1.03A 5of1B-5tbkA:
undetectable		 5of1B-5tbkA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 11 PRO A 129
VAL A 173
SER A 168
LEU A 139
THR A 140
 None
 1.31A 5tiyA-5tbkA:
undetectable		 5tiyA-5tbkA:
18.45