SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tbx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_D_TRPD81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	5tbx	COLD-INDUCIBLE RNA-BINDING PROTEIN (Homo sapiens)	5 / 7	SER A 22 VAL A 80 GLY A 12 THR A 18 ILE A 78	None	1.28A	1gtnC-5tbxA: undetectable 1gtnD-5tbxA: undetectable	1gtnC-5tbxA: 20.00 1gtnD-5tbxA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_L_TRPL81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	5tbx	COLD-INDUCIBLE RNA-BINDING PROTEIN (Homo sapiens)	5 / 9	VAL A 80 GLY A 12 THR A 18 ILE A 78 SER A 22	None	1.32A	1gtnL-5tbxA: undetectable 1gtnM-5tbxA: undetectable	1gtnL-5tbxA: 20.00 1gtnM-5tbxA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CZM_B_HISB402_0 (ATP PHOSPHORIBOSYLTRANSF ERASE CATALYTIC SUBUNIT)	5tbx	COLD-INDUCIBLE RNA-BINDING PROTEIN (Homo sapiens)	5 / 9	VAL A 53 LEU A 23 GLY A 13 LEU A 14 VAL A 80	None	1.29A	6czmA-5tbxA: 4.0 6czmB-5tbxA: 4.0	6czmA-5tbxA: 14.53 6czmB-5tbxA: 14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CZM_E_HISE402_0 (ATP PHOSPHORIBOSYLTRANSF ERASE CATALYTIC SUBUNIT)	5tbx	COLD-INDUCIBLE RNA-BINDING PROTEIN (Homo sapiens)	5 / 9	VAL A 53 LEU A 23 GLY A 13 LEU A 14 VAL A 80	None	1.23A	6czmD-5tbxA: 3.9 6czmE-5tbxA: undetectable	6czmD-5tbxA: 14.53 6czmE-5tbxA: 14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CZM_F_HISF402_0 (ATP PHOSPHORIBOSYLTRANSF ERASE CATALYTIC SUBUNIT)	5tbx	COLD-INDUCIBLE RNA-BINDING PROTEIN (Homo sapiens)	5 / 10	VAL A 53 LEU A 23 GLY A 13 LEU A 14 VAL A 80	None	1.25A	6czmE-5tbxA: undetectable 6czmF-5tbxA: 3.8	6czmE-5tbxA: 14.53 6czmF-5tbxA: 14.53

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GTN_D_TRPD81_0","TRP RNA-BINDING ATTENUATION PROTEIN","5tbx","COLD-INDUCIBLE RNA-BINDING PROTEIN","Homo sapiens",5,"SER A  22;VAL A  80;GLY A  12;THR A  18;ILE A  78","None","1.28A","1gtnC-5tbxA:undetectable;1gtnD-5tbxA:undetectable","1gtnC-5tbxA:20.00;1gtnD-5tbxA:20.00"],["1GTN_L_TRPL81_0","TRP RNA-BINDING ATTENUATION PROTEIN","5tbx","COLD-INDUCIBLE RNA-BINDING PROTEIN","Homo sapiens",5,"VAL A  80;GLY A  12;THR A  18;ILE A  78;SER A  22","None","1.32A","1gtnL-5tbxA:undetectable;1gtnM-5tbxA:undetectable","1gtnL-5tbxA:20.00;1gtnM-5tbxA:20.00"],["6CZM_B_HISB402_0","ATP PHOSPHORIBOSYLTRANSFERASE CATALYTIC SUBUNIT","5tbx","COLD-INDUCIBLE RNA-BINDING PROTEIN","Homo sapiens",5,"VAL A  53;LEU A  23;GLY A  13;LEU A  14;VAL A  80","None","1.29A","6czmA-5tbxA:4.0;6czmB-5tbxA:4.0","6czmA-5tbxA:14.53;6czmB-5tbxA:14.53"],["6CZM_E_HISE402_0","ATP PHOSPHORIBOSYLTRANSFERASE CATALYTIC SUBUNIT","5tbx","COLD-INDUCIBLE RNA-BINDING PROTEIN","Homo sapiens",5,"VAL A  53;LEU A  23;GLY A  13;LEU A  14;VAL A  80","None","1.23A","6czmD-5tbxA:3.9;6czmE-5tbxA:undetectable","6czmD-5tbxA:14.53;6czmE-5tbxA:14.53"],["6CZM_F_HISF402_0","ATP PHOSPHORIBOSYLTRANSFERASE CATALYTIC SUBUNIT","5tbx","COLD-INDUCIBLE RNA-BINDING PROTEIN","Homo sapiens",5,"VAL A  53;LEU A  23;GLY A  13;LEU A  14;VAL A  80","None","1.25A","6czmE-5tbxA:undetectable;6czmF-5tbxA:3.8","6czmE-5tbxA:14.53;6czmF-5tbxA:14.53"]]