SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 5tc1 MATURATION PROTEIN
(Escherichia
virus
MS2) 		5 / 12 LEU M 153
ALA M 383
SER M 373
LEU M 272
ALA M 150
 None
 0.99A 1ao8A-5tc1M:
undetectable		 1ao8A-5tc1M:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 5tc1 MATURATION PROTEIN
(Escherichia
virus
MS2) 		4 / 8 THR M  40
PRO M  41
GLY M  42
PHE M   4
 None
None
None
U  R3553 ( 3.8A)
 0.81A 1h4oB-5tc1M:
undetectable		 1h4oB-5tc1M:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 5tc1 MATURATION PROTEIN
(Escherichia
virus
MS2) 		4 / 8 THR M  40
PRO M  41
GLY M  42
PHE M   4
 None
None
None
U  R3553 ( 3.8A)
 0.80A 1oc3A-5tc1M:
undetectable		 1oc3A-5tc1M:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5tc1 MATURATION PROTEIN
(Escherichia
virus
MS2) 		4 / 8 SER M 151
ALA M 383
ALA M 159
LEU M 206
 None
 0.87A 2bxmA-5tc1M:
1.5		 2bxmA-5tc1M:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5tc1 MATURATION PROTEIN
(Escherichia
virus
MS2) 		4 / 7 ARG M 168
TRP M 196
ALA M 163
ALA M 175
 None
 1.04A 2ejfA-5tc1M:
undetectable		 2ejfA-5tc1M:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5tc1 MATURATION PROTEIN
(Escherichia
virus
MS2) 		5 / 10 ALA M 150
LEU M 310
LEU M 222
ILE M 267
THR M 149
 None
 1.13A 3fl9E-5tc1M:
undetectable		 3fl9E-5tc1M:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5tc1 MATURATION PROTEIN
(Escherichia
virus
MS2) 		5 / 12 CYH M 101
ALA M  98
LEU M  96
ALA M 349
ILE M 333
 None
 1.13A 3ut5B-5tc1M:
undetectable		 3ut5B-5tc1M:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5tc1 MATURATION PROTEIN
(Escherichia
virus
MS2) 		4 / 5 LEU M  65
SER M 100
LEU M 104
LEU M 111
 None
 1.17A 4n09B-5tc1M:
undetectable		 4n09B-5tc1M:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 5tc1 MATURATION PROTEIN
(Escherichia
virus
MS2) 		4 / 5 LEU M  65
SER M 100
LEU M 104
LEU M 111
 None
 1.18A 4n09D-5tc1M:
undetectable		 4n09D-5tc1M:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tc1 MATURATION PROTEIN
(Escherichia
virus
MS2) 		3 / 3 SER M 376
LEU M 275
MET M 306
 None
 0.87A 5ikrB-5tc1M:
undetectable		 5ikrB-5tc1M:
20.88