SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.93A 1c6yA-5tc4A:
undetectable		 1c6yA-5tc4A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A  45
VAL A 180
ILE A 251
ILE A 305
ILE A 183
 None
 0.98A 1hpvA-5tc4A:
undetectable		 1hpvA-5tc4A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A  45
VAL A 180
ILE A 251
ILE A 305
ILE A 183
 None
 1.01A 1ohrB-5tc4A:
undetectable		 1ohrB-5tc4A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A  45
GLU A 182
TRP A 181
THR A 191
 None
 1.41A 1qvuA-5tc4A:
undetectable		 1qvuA-5tc4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.76A 1sdvB-5tc4A:
undetectable		 1sdvB-5tc4A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ILE A  40
ASP A 273
PHE A 295
 None
 0.64A 1uwjB-5tc4A:
undetectable		 1uwjB-5tc4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A 292
GLY A 255
ALA A 254
GLY A 206
VAL A 205
 None
NAD  A 401 (-3.2A)
NAD  A 401 (-3.4A)
None
NAD  A 401 (-4.1A)
 0.85A 2avsA-5tc4A:
undetectable		 2avsA-5tc4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 299
GLU A  36
GLN A 300
 None
 0.97A 2p16A-5tc4A:
undetectable		 2p16A-5tc4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.96A 2pymB-5tc4A:
undetectable		 2pymB-5tc4A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.94A 2pynB-5tc4A:
undetectable		 2pynB-5tc4A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 VAL A 308
GLY A 310
PRO A 314
THR A 316
GLY A 179
 None
L34  A 402 (-3.6A)
L34  A 402 (-4.5A)
NAD  A 401 (-3.2A)
None
 1.21A 3bjwG-5tc4A:
undetectable		 3bjwG-5tc4A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 128
VAL A  72
ALA A 328
THR A 324
LEU A 320
 None
 1.38A 3dh0A-5tc4A:
undetectable		 3dh0A-5tc4A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A  45
VAL A 180
ILE A 251
ILE A 305
ILE A 183
 None
 1.09A 3ekqB-5tc4A:
undetectable		 3ekqB-5tc4A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.92A 3ekxB-5tc4A:
undetectable		 3ekxB-5tc4A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.95A 3lzvB-5tc4A:
undetectable		 3lzvB-5tc4A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  45
VAL A 180
ILE A 251
ILE A 305
ILE A 183
 None
 0.95A 3nduC-5tc4A:
undetectable		 3nduC-5tc4A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.94A 3nu6A-5tc4A:
undetectable		 3nu6A-5tc4A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.84A 3nujA-5tc4A:
undetectable		 3nujA-5tc4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.79A 3pwrB-5tc4A:
undetectable		 3pwrB-5tc4A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ASP A 273
ILE A 272
VAL A 312
GLY A  42
ILE A 189
 None
None
NAD  A 401 ( 4.3A)
None
None
 0.93A 3s43A-5tc4A:
undetectable		 3s43A-5tc4A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.86A 4njtA-5tc4A:
undetectable		 4njtA-5tc4A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.92A 4rvjA-5tc4A:
undetectable		 4rvjA-5tc4A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 269
VAL A 298
ILE A 305
ILE A 251
ILE A 265
 None
 0.91A 4rvjC-5tc4A:
undetectable		 4rvjC-5tc4A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A  45
VAL A 180
ILE A 251
ILE A 305
ILE A 183
 None
 0.99A 5kqxB-5tc4A:
undetectable		 5kqxB-5tc4A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A  69
ASN A  98
ALA A  92
 None
 0.82A 5n4tB-5tc4A:
undetectable		 5n4tB-5tc4A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN A 132
LEU A 133
PRO A 134
ASP A 155
THR A 176
 L34  A 402 (-3.4A)
L34  A 402 (-4.1A)
None
L34  A 402 (-2.9A)
NAD  A 401 (-3.2A)
 0.80A 6debB-5tc4A:
41.6		 6debB-5tc4A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		10 / 12 LEU A 130
GLN A 132
LEU A 133
PRO A 134
ASP A 155
PHE A 157
THR A 176
SER A 202
VAL A 205
THR A 316
 L34  A 402 ( 4.7A)
L34  A 402 (-3.4A)
L34  A 402 (-4.1A)
None
L34  A 402 (-2.9A)
L34  A 402 (-4.9A)
NAD  A 401 (-3.2A)
NAD  A 401 (-2.4A)
NAD  A 401 (-4.1A)
NAD  A 401 (-3.2A)
 0.63A 6debB-5tc4A:
41.6		 6debB-5tc4A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 130
LEU A 133
PRO A 134
ASP A 155
THR A 316
 L34  A 402 ( 4.7A)
L34  A 402 (-4.1A)
None
L34  A 402 (-2.9A)
NAD  A 401 (-3.2A)
 0.97A 6debB-5tc4A:
41.6		 6debB-5tc4A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LYS A  88
GLN A 132
GLY A 255
ILE A 276
 L34  A 402 (-2.8A)
L34  A 402 (-3.4A)
NAD  A 401 (-3.2A)
NAD  A 401 ( 3.2A)
 0.95A 6debB-5tc4A:
41.6		 6debB-5tc4A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 TYR A  84
LYS A  88
GLN A 132
GLY A 255
 L34  A 402 (-3.4A)
L34  A 402 (-2.8A)
L34  A 402 (-3.4A)
NAD  A 401 (-3.2A)
 0.47A 6debB-5tc4A:
41.6		 6debB-5tc4A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 TYR A  84
LYS A  88
GLN A 132
GLY A 291
 L34  A 402 (-3.4A)
L34  A 402 (-2.8A)
L34  A 402 (-3.4A)
None
 1.49A 6debB-5tc4A:
41.6		 6debB-5tc4A:
15.94