SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tcb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 282
LEU A 246
VAL A 234
ASP A 260
 None
 1.36A 1dz6A-5tcbA:
undetectable		 1dz6A-5tcbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 6 THR A 288
LEU A 262
GLY A 223
TYR A 231
 None
 1.27A 1gtiC-5tcbA:
undetectable		 1gtiC-5tcbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 143
ALA A 146
LEU A 142
LEU A 196
LEU A 159
 None
 1.21A 1ie4A-5tcbA:
undetectable
1ie4C-5tcbA:
undetectable		 1ie4A-5tcbA:
19.15
1ie4C-5tcbA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 133
ALA A 147
ALA A 146
VAL A  99
LEU A 184
 None
 1.26A 1rbpA-5tcbA:
undetectable		 1rbpA-5tcbA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 143
ALA A 146
LEU A 142
LEU A 196
LEU A 159
 None
 1.26A 1tz8A-5tcbA:
undetectable
1tz8B-5tcbA:
undetectable		 1tz8A-5tcbA:
19.86
1tz8B-5tcbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 196
LEU A 159
LEU A 143
ALA A 146
LEU A 142
 None
 1.31A 1tz8A-5tcbA:
undetectable
1tz8B-5tcbA:
undetectable		 1tz8A-5tcbA:
19.86
1tz8B-5tcbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 295
PRO A 284
ALA A 258
ILE A 259
 None
 0.83A 2aofA-5tcbA:
undetectable		 2aofA-5tcbA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 220
SER A 219
LEU A 277
GLU A 280
 None
 0.98A 2cdqA-5tcbA:
undetectable		 2cdqA-5tcbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 220
PHE A 197
PHE A  54
GLY A 223
 None
 1.10A 3em0B-5tcbA:
undetectable		 3em0B-5tcbA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 291
VAL A  72
ASN A 199
ALA A 216
PHE A 197
 None
 1.45A 3nuvA-5tcbA:
undetectable		 3nuvA-5tcbA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 142
LEU A 143
ALA A 140
GLY A 117
LEU A 114
 None
 0.84A 3olsA-5tcbA:
undetectable		 3olsA-5tcbA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 142
LEU A 143
ALA A 140
GLY A 117
LEU A 114
 None
 0.89A 3q95B-5tcbA:
undetectable		 3q95B-5tcbA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 202
VAL A 217
ILE A 220
GLU A 203
 None
 1.03A 4a97D-5tcbA:
undetectable		 4a97D-5tcbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 202
VAL A 217
ILE A 220
GLU A 203
 None
 1.09A 4a97H-5tcbA:
undetectable		 4a97H-5tcbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 11 TRP A 138
GLY A 175
ALA A 134
LEU A 133
ALA A 108
 None
 1.13A 4l6v1-5tcbA:
undetectable
4l6v6-5tcbA:
undetectable		 4l6v1-5tcbA:
16.22
4l6v6-5tcbA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 142
LEU A 143
ALA A 140
GLY A 117
LEU A 114
 None
 0.86A 4pxmA-5tcbA:
undetectable		 4pxmA-5tcbA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 7 GLU A  88
LYS A  87
LEU A  86
LEU A  73
 None
 0.73A 4wg0B-5tcbA:
undetectable
4wg0C-5tcbA:
undetectable		 4wg0B-5tcbA:
2.92
4wg0C-5tcbA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  73
GLU A  88
LYS A  87
LEU A  86
 None
 0.73A 4wg0L-5tcbA:
undetectable
4wg0M-5tcbA:
undetectable		 4wg0L-5tcbA:
2.92
4wg0M-5tcbA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 162
ALA A 179
VAL A  99
VAL A 211
PHE A 198
 None
 0.88A 4wnwB-5tcbA:
undetectable		 4wnwB-5tcbA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 205
LEU A 162
ASN A 199
VAL A 211
ALA A 212
 None
 1.24A 4x1iB-5tcbA:
undetectable		 4x1iB-5tcbA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 5tcb PELA
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  65
GLY A 295
ASP A 298
ILE A 259
VAL A  71
 None
 1.03A 5kr0B-5tcbA:
undetectable		 5kr0B-5tcbA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 5 VAL A  72
PRO A  93
GLY A 156
TYR A 154
 None
 1.38A 5x80A-5tcbA:
undetectable
5x80B-5tcbA:
undetectable		 5x80A-5tcbA:
28.99
5x80B-5tcbA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 6 GLY A  90
VAL A  52
PHE A  94
PHE A 197
 None
 1.04A 6h7lA-5tcbA:
undetectable		 6h7lA-5tcbA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5tcb PELA
(Pseudomonas
aeruginosa) 		4 / 6 GLY A  90
VAL A  52
PHE A  94
PHE A 197
 None
 1.04A 6h7lB-5tcbA:
undetectable		 6h7lB-5tcbA:
16.42