SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 11 GLN B 229
ILE B 254
ALA B 226
VAL B 386
ALA B 368
 None
 1.28A 1n4hA-5tchB:
undetectable		 1n4hA-5tchB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 GLU B 326
GLY B 268
VAL B 323
LEU B 375
PHE B 285
 None
 1.31A 1nw3A-5tchB:
undetectable		 1nw3A-5tchB:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 ASP B 319
GLY B 288
SER B 289
ALA B 282
ALA B 283
 None
 1.18A 1nw5A-5tchB:
undetectable		 1nw5A-5tchB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY B  17
GLY B  27
GLY B  26
PRO B 325
ASP B  12
 None
 1.06A 1qzzA-5tchB:
undetectable		 1qzzA-5tchB:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		6 / 12 VAL B 215
LEU B 139
ALA B 136
LEU B 106
ASN B 104
ALA B 112
 None
 1.40A 1sa1A-5tchB:
undetectable
1sa1B-5tchB:
undetectable		 1sa1A-5tchB:
23.20
1sa1B-5tchB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		6 / 12 VAL B 215
LEU B 139
ALA B 136
LEU B 106
ASN B 104
ALA B 112
 None
 1.42A 1sa1C-5tchB:
undetectable
1sa1D-5tchB:
undetectable		 1sa1C-5tchB:
23.20
1sa1D-5tchB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY B  17
GLY B  27
GLY B  26
PRO B 325
ASP B  12
 None
 1.11A 1xdsA-5tchB:
undetectable		 1xdsA-5tchB:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY B  17
GLY B  27
GLY B  26
PRO B 325
ASP B  12
 None
 1.06A 1xdsB-5tchB:
undetectable		 1xdsB-5tchB:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 7 THR B 284
VAL B 245
GLY B 246
THR B 204
 None
LLP  B 101 ( 4.7A)
LLP  B 101 ( 3.3A)
LLP  B 101 ( 3.7A)
 0.89A 2a1mA-5tchB:
undetectable		 2a1mA-5tchB:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 PHE B 269
ALA B 243
PHE B 285
GLY B 248
LEU B 330
 None
None
None
LLP  B 101 ( 3.3A)
None
 1.44A 3aodC-5tchB:
undetectable		 3aodC-5tchB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		3 / 3 LYS B 395
SER B  99
GLN B 128
 None
LLP  B 101 ( 2.9A)
LLP  B 101 (-3.9A)
 1.17A 3si7A-5tchB:
undetectable		 3si7A-5tchB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 PHE B 285
THR B 284
GLY B 324
GLY B 322
GLY B 248
 None
None
None
None
LLP  B 101 ( 3.3A)
 1.08A 3tegA-5tchB:
undetectable		 3tegA-5tchB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 5 HIS B 100
SER B  99
THR B  97
ASP B 319
 LLP  B 101 ( 3.5A)
LLP  B 101 ( 2.9A)
None
None
 1.43A 3tm4A-5tchB:
2.5		 3tm4A-5tchB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 5 HIS B 100
SER B  99
THR B  97
ASP B 319
 LLP  B 101 ( 3.5A)
LLP  B 101 ( 2.9A)
None
None
 1.38A 3tm4B-5tchB:
2.0		 3tm4B-5tchB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 7 GLU B 326
ILE B 252
PHE B  19
VAL B  30
 None
 1.08A 4a97A-5tchB:
undetectable		 4a97A-5tchB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 7 GLU B 326
ILE B 252
PHE B  19
VAL B  30
 None
 1.06A 4a97D-5tchB:
undetectable		 4a97D-5tchB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 6 GLU B 326
ILE B 252
PHE B  19
VAL B  30
 None
 1.06A 4a97I-5tchB:
undetectable		 4a97I-5tchB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 6 LEU B 140
ALA B 136
LEU B 142
THR B 133
 None
 0.83A 4d7bB-5tchB:
undetectable		 4d7bB-5tchB:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 11 ALA B 122
GLY B 149
GLY B 125
ILE B 146
ASP B 152
 None
None
MLI  B 501 (-3.5A)
None
None
 1.11A 4dcmA-5tchB:
undetectable		 4dcmA-5tchB:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 4 GLY B 176
VAL B 173
PHE B 188
ILE B 184
 None
 1.03A 4xv2B-5tchB:
undetectable		 4xv2B-5tchB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 ASP B 343
ALA B 283
ALA B 282
GLY B 279
THR B 278
 None
 1.10A 5igjA-5tchB:
undetectable		 5igjA-5tchB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 5 HIS B 256
ILE B 252
PHE B  19
ALA B 205
 None
 1.21A 5msdA-5tchB:
undetectable		 5msdA-5tchB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY B 149
TYR B 200
ILE B 121
ALA B 187
VAL B 145
 None
 1.10A 5n0tA-5tchB:
2.0		 5n0tA-5tchB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY B 149
TYR B 200
ILE B 121
ALA B 187
VAL B 145
 None
 1.07A 5n0tB-5tchB:
undetectable		 5n0tB-5tchB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY B 149
TYR B 200
ILE B 121
ALA B 187
VAL B 145
 None
 1.13A 5n0xA-5tchB:
undetectable		 5n0xA-5tchB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 5 HIS B 367
ALA B 282
SER B 313
GLY B 273
 None
 1.27A 5yodB-5tchB:
undetectable		 5yodB-5tchB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL B 323
LEU B 259
HIS B 327
LEU B 330
SER B 298
 None
 1.15A 6b0lB-5tchB:
undetectable		 6b0lB-5tchB:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 9 ALA B 316
GLY B 317
LEU B 318
GLY B 393
ARG B 155
 MLI  B 501 (-3.6A)
LLP  B 101 ( 4.2A)
None
None
None
 1.07A 6nm4B-5tchB:
undetectable		 6nm4B-5tchB:
18.83