SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEU_A_ACTA141_0 (PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE)	5tcm	UNCHARACTERIZED PROTEIN (Leishmania donovani)	3 / 3	VAL A 28 ASP A 50 GLU A 32	None	0.68A	2qeuA-5tcmA: undetectable	2qeuA-5tcmA: 20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEU_C_ACTC141_0 (PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE)	5tcm	UNCHARACTERIZED PROTEIN (Leishmania donovani)	3 / 3	VAL A 28 ASP A 50 GLU A 32	None	0.67A	2qeuC-5tcmA: undetectable	2qeuC-5tcmA: 20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y1Y_A_HNQA201_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5tcm	UNCHARACTERIZED PROTEIN (Leishmania donovani)	5 / 8	VAL A 30 LEU A 37 CYH A 83 TYR A 86 ASN A 87	R78 A 201 (-4.4A) None R78 A 201 ( 3.9A) R78 A 201 (-4.5A) R78 A 201 (-3.4A)	0.78A	5y1yA-5tcmA: 11.5	5y1yA-5tcmA: 25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H3D_A_DHIA601_0 (DUF2338 DOMAIN-CONTAINING PROTEIN)	5tcm	UNCHARACTERIZED PROTEIN (Leishmania donovani)	4 / 5	TYR A 65 ASN A 6 TYR A 5 PHE A 2	None	1.42A	6h3dA-5tcmA: undetectable	6h3dA-5tcmA: 15.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2QEU_A_ACTA141_0","PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE","5tcm","UNCHARACTERIZED PROTEIN","Leishmania donovani",3,"VAL A  28;ASP A  50;GLU A  32","None","0.68A","2qeuA-5tcmA:undetectable","2qeuA-5tcmA:20.95"],["2QEU_C_ACTC141_0","PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE","5tcm","UNCHARACTERIZED PROTEIN","Leishmania donovani",3,"VAL A  28;ASP A  50;GLU A  32","None","0.67A","2qeuC-5tcmA:undetectable","2qeuC-5tcmA:20.95"],["5Y1Y_A_HNQA201_1","BROMODOMAIN-CONTAINING PROTEIN 4","5tcm","UNCHARACTERIZED PROTEIN","Leishmania donovani",5,"VAL A  30;LEU A  37;CYH A  83;TYR A  86;ASN A  87","R78 A 201 (-4.4A);None;R78 A 201 ( 3.9A);R78 A 201 (-4.5A);R78 A 201 (-3.4A)","0.78A","5y1yA-5tcmA:11.5","5y1yA-5tcmA:25.93"],["6H3D_A_DHIA601_0","DUF2338 DOMAIN-CONTAINING PROTEIN","5tcm","UNCHARACTERIZED PROTEIN","Leishmania donovani",4,"TYR A  65;ASN A   6;TYR A   5;PHE A   2","None","1.42A","6h3dA-5tcmA:undetectable","6h3dA-5tcmA:15.81"]]