SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5tcs KINETOCHORE PROTEIN
SPC24
KINETOCHORE PROTEIN
SPC25
(Saccharomyces
cerevisiae) 		4 / 8 LEU D 210
TYR C 165
GLY C 169
LEU D 206
 None
 0.97A 1s1xA-5tcsD:
undetectable		 1s1xA-5tcsD:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5tcs KINETOCHORE PROTEIN
NDC80
(Saccharomyces
cerevisiae) 		5 / 12 MET A 221
LEU A 191
SER A 213
SER A 205
ILE A 187
 None
 1.27A 1xotA-5tcsA:
undetectable		 1xotA-5tcsA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5tcs KINETOCHORE PROTEIN
NDC80
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 217
SER A 205
GLN A 206
 None
 1.32A 3si7A-5tcsA:
undetectable		 3si7A-5tcsA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5tcs KINETOCHORE PROTEIN
NDC80
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 137
ASN A 229
ASP A 142
 None
 0.76A 4o1eA-5tcsA:
undetectable		 4o1eA-5tcsA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5tcs KINETOCHORE PROTEIN
SPC25
(Saccharomyces
cerevisiae) 		4 / 8 ILE D 181
LEU D 196
LEU D 217
PHE D 163
 None
 0.74A 4qopC-5tcsD:
undetectable		 4qopC-5tcsD:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 5tcs KINETOCHORE PROTEIN
NDC80
(Saccharomyces
cerevisiae) 		5 / 12 SER A 213
GLY A 211
GLY A 212
PHE A 218
GLN A 206
 None
 1.28A 4ubeA-5tcsA:
undetectable		 4ubeA-5tcsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 5tcs KINETOCHORE PROTEIN
SPC25
(Saccharomyces
cerevisiae) 		5 / 12 LEU D 210
ALA D 213
LEU D 196
LEU D 200
LEU D 217
 None
 1.21A 4zn7A-5tcsD:
undetectable		 4zn7A-5tcsD:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 5tcs KINETOCHORE PROTEIN
NDC80
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 190
MET A 221
LEU A 169
ILE A 187
 None
 0.57A 5uihA-5tcsA:
undetectable		 5uihA-5tcsA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5tcs KINETOCHORE PROTEIN
NDC80
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 188
ILE A 187
ILE A 183
ILE A 202
ASN A 203
 None
 1.37A 5vkqA-5tcsA:
3.8
5vkqD-5tcsA:
3.8		 5vkqA-5tcsA:
9.55
5vkqD-5tcsA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5tcs KINETOCHORE PROTEIN
NDC80
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 202
ASN A 203
TYR A 188
ILE A 187
ILE A 183
 None
 1.36A 5vkqA-5tcsA:
3.7
5vkqB-5tcsA:
3.8		 5vkqA-5tcsA:
9.55
5vkqB-5tcsA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5tcs KINETOCHORE PROTEIN
NDC80
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 202
ASN A 203
TYR A 188
ILE A 187
ILE A 183
 None
 1.34A 5vkqC-5tcsA:
3.7
5vkqD-5tcsA:
3.8		 5vkqC-5tcsA:
9.55
5vkqD-5tcsA:
9.55