SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5td7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 5td7 ZGC:55652
(Danio
rerio) 		6 / 11 HIS A 136
HIS A 137
PHE A 146
ASP A 174
HIS A 176
ASP A 267
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
 0.36A 1c3sA-5td7A:
41.3		 1c3sA-5td7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 9 GLY A 178
GLY A 135
GLY A 265
GLY A 305
ASP A 267
 None
None
None
FKS  A 711 (-3.2A)
ZN  A 701 ( 2.6A)
 1.10A 1mxdA-5td7A:
undetectable		 1mxdA-5td7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 11 GLY A 178
GLY A 135
GLY A 265
GLY A 305
ASP A 267
 None
None
None
FKS  A 711 (-3.2A)
ZN  A 701 ( 2.6A)
 1.02A 1mxgA-5td7A:
undetectable		 1mxgA-5td7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 8 ASP A  10
SER A  14
ARG A  15
ALA A 111
 None
 1.05A 1rqpC-5td7A:
2.6		 1rqpC-5td7A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 8 ASP A  10
SER A  14
ARG A  15
ALA A 111
 None
 1.08A 1rqpA-5td7A:
undetectable		 1rqpA-5td7A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		8 / 12 ASP A  94
HIS A 136
HIS A 137
GLY A 145
PHE A 146
ASP A 174
HIS A 176
ASP A 267
 FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
 0.64A 1t69A-5td7A:
41.6		 1t69A-5td7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 TYR A  96
HIS A 137
GLY A 145
HIS A 176
ASP A 267
 None
FKS  A 711 (-3.5A)
FKS  A 711 (-4.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
 1.30A 1t69A-5td7A:
41.6		 1t69A-5td7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.68A 1v54A-5td7A:
undetectable		 1v54A-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 1v54N-5td7A:
undetectable		 1v54N-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.71A 1v55A-5td7A:
undetectable		 1v55A-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 1v55N-5td7A:
0.8		 1v55N-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 LEU A 549
LEU A 594
MET A 601
 None
 0.81A 1ya3B-5td7A:
undetectable		 1ya3B-5td7A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5td7 ZGC:55652
(Danio
rerio) 		6 / 11 HIS A 136
HIS A 137
ASP A 174
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.17A 1zz1A-5td7A:
49.4		 1zz1A-5td7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5td7 ZGC:55652
(Danio
rerio) 		7 / 11 HIS A 136
HIS A 137
PHE A 146
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.34A 1zz1A-5td7A:
49.4		 1zz1A-5td7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5td7 ZGC:55652
(Danio
rerio) 		6 / 12 HIS A 136
HIS A 137
ASP A 174
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.18A 1zz1B-5td7A:
49.9
1zz1C-5td7A:
49.8		 1zz1B-5td7A:
22.94
1zz1C-5td7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5td7 ZGC:55652
(Danio
rerio) 		7 / 12 HIS A 136
HIS A 137
PHE A 146
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.31A 1zz1B-5td7A:
49.9
1zz1C-5td7A:
49.8		 1zz1B-5td7A:
22.94
1zz1C-5td7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5td7 ZGC:55652
(Danio
rerio) 		6 / 12 HIS A 136
HIS A 137
ASP A 174
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.17A 1zz1C-5td7A:
49.8		 1zz1C-5td7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5td7 ZGC:55652
(Danio
rerio) 		7 / 12 HIS A 136
HIS A 137
GLY A 145
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.37A 1zz1C-5td7A:
49.8		 1zz1C-5td7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5td7 ZGC:55652
(Danio
rerio) 		6 / 9 HIS A 136
HIS A 137
PHE A 146
ASP A 174
HIS A 176
ASP A 267
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
 0.33A 1zz1D-5td7A:
49.5		 1zz1D-5td7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.67A 2dyrA-5td7A:
undetectable		 2dyrA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 2dyrN-5td7A:
undetectable		 2dyrN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 2dysA-5td7A:
undetectable		 2dysA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.68A 2dysN-5td7A:
undetectable		 2dysN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 2eijA-5td7A:
0.9		 2eijA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.68A 2eijN-5td7A:
0.8		 2eijN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 2eikA-5td7A:
undetectable		 2eikA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 2eikN-5td7A:
undetectable		 2eikN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 2eilA-5td7A:
undetectable		 2eilA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.68A 2eilN-5td7A:
undetectable		 2eilN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.67A 2eimA-5td7A:
undetectable		 2eimA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.75A 2eimN-5td7A:
undetectable		 2eimN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.72A 2einA-5td7A:
undetectable		 2einA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 VAL A 247
ALA A 252
LEU A 291
PHE A 194
SER A 195
 None
None
None
None
K  A 702 (-2.8A)
 1.24A 2oipC-5td7A:
3.3		 2oipC-5td7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 8 ASP A  10
SER A  14
ARG A  15
ALA A 111
 None
 1.04A 2v7uA-5td7A:
undetectable		 2v7uA-5td7A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 6 LEU A 291
SER A 268
PHE A 266
ASP A 267
 None
None
None
ZN  A 701 ( 2.6A)
 1.22A 2vn1B-5td7A:
undetectable		 2vn1B-5td7A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 2y69A-5td7A:
undetectable		 2y69A-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.65A 2y69N-5td7A:
undetectable		 2y69N-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 2zxwA-5td7A:
undetectable		 2zxwA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.65A 2zxwN-5td7A:
undetectable		 2zxwN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 6 ARG A 660
LEU A 661
GLN A 662
LEU A 547
 None
 0.97A 2zxwP-5td7A:
undetectable
2zxwW-5td7A:
undetectable		 2zxwP-5td7A:
17.28
2zxwW-5td7A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 MET A  13
GLU A  28
ASP A 267
 None
None
ZN  A 701 ( 2.6A)
 0.97A 3a25A-5td7A:
3.4		 3a25A-5td7A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.74A 3abkN-5td7A:
undetectable		 3abkN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 3ablA-5td7A:
0.8		 3ablA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 3ablN-5td7A:
0.8		 3ablN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.72A 3abmA-5td7A:
undetectable		 3abmA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.63A 3abmN-5td7A:
undetectable		 3abmN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.72A 3ag1A-5td7A:
undetectable		 3ag1A-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 6 ARG A 660
LEU A 661
GLN A 662
LEU A 547
 None
 0.88A 3ag1C-5td7A:
undetectable
3ag1J-5td7A:
undetectable		 3ag1C-5td7A:
17.28
3ag1J-5td7A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.67A 3ag1N-5td7A:
undetectable		 3ag1N-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.74A 3ag3A-5td7A:
undetectable		 3ag3A-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.74A 3ag3N-5td7A:
undetectable		 3ag3N-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.72A 3ag4N-5td7A:
undetectable		 3ag4N-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.68A 3asnA-5td7A:
undetectable		 3asnA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 3asnN-5td7A:
undetectable		 3asnN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.67A 3asoA-5td7A:
undetectable		 3asoA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 3asoN-5td7A:
0.9		 3asoN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 5 HIS A 136
HIS A 137
ASP A 174
HIS A 176
ASP A 267
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
 0.14A 3c0zA-5td7A:
53.8		 3c0zA-5td7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5td7 ZGC:55652
(Danio
rerio) 		6 / 8 HIS A 136
HIS A 137
ASP A 174
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.29A 3c0zB-5td7A:
54.3		 3c0zB-5td7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5td7 ZGC:55652
(Danio
rerio) 		7 / 8 HIS A 136
HIS A 137
PHE A 146
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.32A 3c0zB-5td7A:
54.3		 3c0zB-5td7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5td7 ZGC:55652
(Danio
rerio) 		6 / 6 ASP A  94
HIS A 136
HIS A 137
ASP A 174
HIS A 176
ASP A 267
 FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
 0.70A 3c0zC-5td7A:
53.8		 3c0zC-5td7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 LEU A 294
LEU A 291
LEU A 566
LEU A 640
MET A 562
 None
 1.14A 3d90B-5td7A:
undetectable		 3d90B-5td7A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 3dtuA-5td7A:
undetectable		 3dtuA-5td7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 3dtuC-5td7A:
undetectable		 3dtuC-5td7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 5 ARG A 463
ILE A 437
VAL A 445
THR A 457
 None
 1.21A 3eigA-5td7A:
undetectable		 3eigA-5td7A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 LEU A 568
GLN A 533
PHE A 530
ASP A 541
THR A 539
 None
 1.30A 3gwuA-5td7A:
undetectable		 3gwuA-5td7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.77A 3s3bA-5td7A:
2.2		 3s3bA-5td7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 5 TYR A 574
PHE A 245
PRO A 571
LEU A 249
 None
 1.42A 3tgvC-5td7A:
undetectable		 3tgvC-5td7A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.65A 3wg7A-5td7A:
0.9		 3wg7A-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 3wg7N-5td7A:
undetectable		 3wg7N-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.74A 3x2qA-5td7A:
undetectable		 3x2qA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.64A 3x2qN-5td7A:
undetectable		 3x2qN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 7 GLU A  28
TYR A  16
HIS A 103
VAL A  74
 None
 1.00A 4a97D-5td7A:
undetectable		 4a97D-5td7A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 6 GLU A  28
TYR A  16
HIS A 103
VAL A  74
 None
 1.22A 4a97E-5td7A:
undetectable		 4a97E-5td7A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 7 GLU A  28
TYR A  16
HIS A 103
VAL A  74
 None
 1.09A 4a97H-5td7A:
undetectable		 4a97H-5td7A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		7 / 10 HIS A 136
HIS A 137
ASP A 174
HIS A 176
ASP A 267
PRO A 273
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
FKS  A 711 (-3.2A)
 0.51A 4bz6A-5td7A:
40.1		 4bz6A-5td7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 10 HIS A 136
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.22A 4bz6A-5td7A:
40.1		 4bz6A-5td7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		7 / 12 HIS A 136
HIS A 137
ASP A 174
HIS A 176
ASP A 267
PRO A 273
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
FKS  A 711 (-3.2A)
 0.49A 4bz6A-5td7A:
40.1
4bz6B-5td7A:
40.1		 4bz6A-5td7A:
22.21
4bz6B-5td7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 HIS A 136
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.21A 4bz6A-5td7A:
40.1
4bz6B-5td7A:
40.1		 4bz6A-5td7A:
22.21
4bz6B-5td7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		8 / 12 HIS A 136
HIS A 137
GLY A 145
ASP A 174
HIS A 176
ASP A 267
PRO A 273
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
FKS  A 711 (-3.2A)
 0.54A 4bz6C-5td7A:
40.1		 4bz6C-5td7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 HIS A 136
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.20A 4bz6C-5td7A:
40.1		 4bz6C-5td7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		7 / 10 HIS A 136
HIS A 137
ASP A 174
HIS A 176
ASP A 267
PRO A 273
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
FKS  A 711 (-3.2A)
 0.51A 4bz6D-5td7A:
40.5		 4bz6D-5td7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 10 HIS A 136
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.21A 4bz6D-5td7A:
40.5		 4bz6D-5td7A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 8 GLN A 179
ASN A  93
GLN A 139
ASN A 150
 None
 1.37A 4d1yA-5td7A:
3.6
4d1yB-5td7A:
3.7		 4d1yA-5td7A:
13.09
4d1yB-5td7A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 11 VAL A 320
ALA A  46
PHE A   9
LEU A 303
VAL A 316
 None
 1.32A 4eilA-5td7A:
2.9		 4eilA-5td7A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 11 VAL A 320
ALA A  46
PHE A   9
LEU A 303
VAL A 316
 None
 1.30A 4eilC-5td7A:
2.8		 4eilC-5td7A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 5 VAL A 471
ARG A 474
MET A 475
GLU A 480
 None
 1.04A 4hojA-5td7A:
undetectable		 4hojA-5td7A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5td7 ZGC:55652
(Danio
rerio) 		9 / 12 ASP A  94
HIS A 136
HIS A 137
GLY A 145
PHE A 146
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.67A 4lxzA-5td7A:
43.4		 4lxzA-5td7A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5td7 ZGC:55652
(Danio
rerio) 		6 / 12 HIS A 136
HIS A 137
ASP A 174
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.32A 4lxzA-5td7A:
43.4		 4lxzA-5td7A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 PRO A 134
GLY A 178
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.1A)
None
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.21A 4lxzA-5td7A:
43.4		 4lxzA-5td7A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5td7 ZGC:55652
(Danio
rerio) 		8 / 11 ASP A  94
HIS A 136
HIS A 137
PHE A 146
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.67A 4lxzB-5td7A:
43.3		 4lxzB-5td7A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 11 HIS A 136
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.26A 4lxzB-5td7A:
43.3		 4lxzB-5td7A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5td7 ZGC:55652
(Danio
rerio) 		9 / 12 ASP A  94
HIS A 136
HIS A 137
GLY A 145
PHE A 146
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.61A 4lxzC-5td7A:
43.4		 4lxzC-5td7A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 6 ASP A  22
GLU A  28
VAL A 148
ALA A 143
 None
 0.93A 4nkxA-5td7A:
undetectable		 4nkxA-5td7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		8 / 12 HIS A 136
HIS A 137
GLY A 145
PHE A 146
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.41A 4qa0A-5td7A:
42.1		 4qa0A-5td7A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 HIS A 136
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.23A 4qa0A-5td7A:
42.1		 4qa0A-5td7A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 TYR A  96
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 None
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.19A 4qa0A-5td7A:
42.1		 4qa0A-5td7A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 11 HIS A 136
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.23A 4qa0B-5td7A:
42.0		 4qa0B-5td7A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		7 / 11 HIS A 136
HIS A 137
PHE A 146
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.40A 4qa0B-5td7A:
42.0		 4qa0B-5td7A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 11 TYR A  96
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 None
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.18A 4qa0B-5td7A:
42.0		 4qa0B-5td7A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		8 / 12 HIS A 136
HIS A 137
GLY A 145
PHE A 146
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.34A 4qa2A-5td7A:
41.6		 4qa2A-5td7A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 HIS A 136
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.21A 4qa2A-5td7A:
41.6		 4qa2A-5td7A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 TYR A  96
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 None
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.12A 4qa2A-5td7A:
41.6		 4qa2A-5td7A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		8 / 12 HIS A 136
HIS A 137
GLY A 145
PHE A 146
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.32A 4qa2B-5td7A:
42.3		 4qa2B-5td7A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 HIS A 136
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.19A 4qa2B-5td7A:
42.3		 4qa2B-5td7A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 TYR A  96
HIS A 137
HIS A 176
ASP A 267
GLY A 265
 None
FKS  A 711 (-3.5A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.15A 4qa2B-5td7A:
42.3		 4qa2B-5td7A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 11 LEU A 192
PHE A 255
ASP A 256
ALA A 252
VAL A 260
 None
 1.40A 4uuuA-5td7A:
undetectable
4uuuB-5td7A:
undetectable		 4uuuA-5td7A:
13.67
4uuuB-5td7A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 5b1aA-5td7A:
undetectable		 5b1aA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.72A 5b1aN-5td7A:
0.9		 5b1aN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.73A 5b1bA-5td7A:
undetectable		 5b1bA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.75A 5b1bN-5td7A:
0.7		 5b1bN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5td7 ZGC:55652
(Danio
rerio) 		7 / 12 HIS A 136
HIS A 137
GLY A 145
PHE A 146
ASP A 174
HIS A 176
ASP A 267
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
 0.17A 5eeiA-5td7A:
60.0		 5eeiA-5td7A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5td7 ZGC:55652
(Danio
rerio) 		7 / 12 HIS A 136
HIS A 137
GLY A 145
PHE A 146
ASP A 174
HIS A 176
ASP A 267
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
 0.16A 5eeiB-5td7A:
60.7		 5eeiB-5td7A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5td7 ZGC:55652
(Danio
rerio) 		6 / 12 HIS A 136
HIS A 137
ASP A 174
HIS A 176
ASP A 267
GLY A 265
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
None
 1.21A 5eenA-5td7A:
60.5		 5eenA-5td7A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5td7 ZGC:55652
(Danio
rerio) 		7 / 12 HIS A 136
HIS A 137
PHE A 146
ASP A 174
HIS A 176
ASP A 267
GLY A 305
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
FKS  A 711 (-3.2A)
 0.22A 5eenA-5td7A:
60.5		 5eenA-5td7A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 5td7 ZGC:55652
(Danio
rerio) 		6 / 12 HIS A 136
HIS A 137
PHE A 146
ASP A 174
HIS A 176
ASP A 267
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
 0.19A 5eenB-5td7A:
59.9		 5eenB-5td7A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 5td7 ZGC:55652
(Danio
rerio) 		6 / 12 HIS A 136
HIS A 137
PHE A 146
ASP A 174
HIS A 176
ASP A 267
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
 0.20A 5ef8A-5td7A:
60.5		 5ef8A-5td7A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 5td7 ZGC:55652
(Danio
rerio) 		6 / 12 HIS A 136
HIS A 137
PHE A 146
ASP A 174
HIS A 176
ASP A 267
 FKS  A 711 (-4.0A)
FKS  A 711 (-3.5A)
FKS  A 711 (-3.9A)
ZN  A 701 (-1.9A)
ZN  A 701 (-3.3A)
ZN  A 701 ( 2.6A)
 0.25A 5ef8B-5td7A:
60.3		 5ef8B-5td7A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 6 HIS A 433
LEU A 427
CYH A 485
LEU A 625
 None
 1.46A 5hrqD-5td7A:
undetectable
5hrqG-5td7A:
undetectable
5hrqH-5td7A:
undetectable		 5hrqD-5td7A:
3.77
5hrqG-5td7A:
2.85
5hrqH-5td7A:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.71A 5iy5A-5td7A:
undetectable		 5iy5A-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.71A 5iy5N-5td7A:
undetectable		 5iy5N-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 5 SER A 118
VAL A 119
GLY A 127
ALA A   6
 None
 1.06A 5k50A-5td7A:
5.8		 5k50A-5td7A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.71A 5w97a-5td7A:
0.9		 5w97a-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.75A 5waua-5td7A:
undetectable		 5waua-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 5 PHE A 194
PHE A 244
LEU A 287
PHE A 284
 None
 1.26A 5wauc-5td7A:
undetectable
5wauj-5td7A:
undetectable		 5wauc-5td7A:
17.28
5wauj-5td7A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.68A 5xdqA-5td7A:
undetectable		 5xdqA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 5xdqN-5td7A:
0.9		 5xdqN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5td7 ZGC:55652
(Danio
rerio) 		4 / 5 PHE A 194
PHE A 244
LEU A 287
PHE A 284
 None
 1.24A 5xdqP-5td7A:
undetectable
5xdqW-5td7A:
undetectable		 5xdqP-5td7A:
17.28
5xdqW-5td7A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 5xdxA-5td7A:
undetectable		 5xdxA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.68A 5xdxN-5td7A:
undetectable		 5xdxN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 5z84A-5td7A:
undetectable		 5z84A-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.67A 5z84N-5td7A:
0.9		 5z84N-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 5z85A-5td7A:
undetectable		 5z85A-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.68A 5z85N-5td7A:
0.9		 5z85N-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.63A 5z86A-5td7A:
0.9		 5z86A-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.65A 5z86N-5td7A:
undetectable		 5z86N-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.70A 5zcoA-5td7A:
undetectable		 5zcoA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.67A 5zcoN-5td7A:
0.9		 5zcoN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.68A 5zcpA-5td7A:
undetectable		 5zcpA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.69A 5zcpN-5td7A:
0.9		 5zcpN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.68A 5zcqA-5td7A:
undetectable		 5zcqA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.67A 5zcqN-5td7A:
0.9		 5zcqN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 HIS A 136
GLY A 178
VAL A 171
ILE A  27
GLY A 145
 FKS  A 711 (-4.0A)
None
None
None
FKS  A 711 (-4.5A)
 1.13A 6c2mB-5td7A:
undetectable		 6c2mB-5td7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 MET A  13
PHE A  97
VAL A  95
VAL A  74
ALA A 109
 None
 1.20A 6djzA-5td7A:
undetectable		 6djzA-5td7A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.67A 6hu9a-5td7A:
undetectable		 6hu9a-5td7A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.72A 6hu9m-5td7A:
undetectable		 6hu9m-5td7A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.71A 6nknA-5td7A:
undetectable		 6nknA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.71A 6nknN-5td7A:
undetectable		 6nknN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.71A 6nmpA-5td7A:
undetectable		 6nmpA-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5td7 ZGC:55652
(Danio
rerio) 		3 / 3 HIS A 176
HIS A 137
HIS A 136
 ZN  A 701 (-3.3A)
FKS  A 711 (-3.5A)
FKS  A 711 (-4.0A)
 0.72A 6nmpN-5td7A:
undetectable		 6nmpN-5td7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 11 ILE A  62
ASN A 150
LEU A 113
GLY A 110
ALA A 155
 None
 1.22A 6r2eF-5td7A:
undetectable		 6r2eF-5td7A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5td7 ZGC:55652
(Danio
rerio) 		5 / 12 ILE A  62
ASN A 150
LEU A 113
GLY A 110
ALA A 155
 None
 1.23A 6r2eH-5td7A:
undetectable		 6r2eH-5td7A:
17.60