SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5td8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)
5td8 KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae)
4 / 5 ILE D 171
ARG D 193
LEU D 217
PRO D 186
None
None
HG  D 301 (-3.0A)
None
1.34A 1s8fA-5td8D:
undetectable
1s8fB-5td8D:
undetectable
1s8fA-5td8D:
20.90
1s8fB-5td8D:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)
5td8 NANOBODY
(Vicugna
pacos)
4 / 5 LEU E  21
GLN E 123
THR E 122
LEU E  87
None
1.22A 3ce6D-5td8E:
undetectable
3ce6D-5td8E:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)
5td8 KINETOCHORE PROTEIN
NUF2

(Saccharomyces
cerevisiae)
3 / 3 CYH B  94
PHE B  97
PHE B  98
HG  B 502 (-3.0A)
HG  B 502 (-4.0A)
HG  B 502 (-4.6A)
0.52A 3cr5X-5td8B:
2.7
3cr5X-5td8B:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)
5td8 NANOBODY
(Vicugna
pacos)
6 / 12 VAL E   3
LEU E   5
ALA E  25
VAL E  80
ALA E  99
TYR E 117
None
0.78A 3qxtB-5td8E:
18.7
3qxtB-5td8E:
68.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)
5td8 KINETOCHORE PROTEIN
SPC24

(Saccharomyces
cerevisiae)
4 / 4 PRO C 193
LEU C 192
ILE C 181
ARG C 210
None
1.40A 3w1wA-5td8C:
undetectable
3w1wA-5td8C:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
5td8 KINETOCHORE PROTEIN
SPC24
KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae)
5 / 10 ALA D 207
GLY C 169
LEU D 145
LEU C 211
ILE C 207
None
1.14A 3wdmB-5td8D:
undetectable
3wdmB-5td8D:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
5td8 KINETOCHORE PROTEIN
SPC24
KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae)
5 / 9 ALA D 207
GLY C 169
LEU D 145
LEU C 211
ILE C 207
None
1.16A 3wdmC-5td8D:
undetectable
3wdmC-5td8D:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)
5td8 KINETOCHORE PROTEIN
NUF2
KINETOCHORE PROTEIN
SPC24
KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae)
4 / 7 PHE D  17
TYR B 442
GLN D  18
PHE C  22
None
1.35A 4grqA-5td8D:
undetectable
4grqC-5td8D:
undetectable
4grqA-5td8D:
21.83
4grqC-5td8D:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)
5td8 KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae)
4 / 8 ILE D 181
LEU D 196
LEU D 217
PHE D 163
None
None
HG  D 301 (-3.0A)
HG  D 301 (-3.6A)
0.80A 4qopC-5td8D:
undetectable
4qopC-5td8D:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)
5td8 KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae)
5 / 12 LEU D 210
ALA D 213
LEU D 196
LEU D 200
LEU D 217
None
None
None
None
HG  D 301 (-3.0A)
1.20A 4zn7A-5td8D:
undetectable
4zn7A-5td8D:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
5td8 NANOBODY
(Vicugna
pacos)
4 / 7 ALA E  93
THR E  92
VAL E 124
GLU E  90
None
0.82A 5ecoD-5td8E:
undetectable
5ecoD-5td8E:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
5td8 KINETOCHORE PROTEIN
SPC24
KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
4 / 5 ILE D 171
PHE D 209
ASN C  60
TYR C 165
None
1.25A 6a93B-5td8D:
undetectable
6a93B-5td8D:
16.12