SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 11 PHE A 210
TYR A 201
LEU A 216
GLN A 218
HIS A 103
 None
 1.49A 1qabE-5tdxA:
undetectable		 1qabE-5tdxA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 10 ASP A 182
LEU A 183
ASP A 119
SER A 115
THR A  53
 None
 1.47A 1rqpA-5tdxA:
3.1		 1rqpA-5tdxA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 10 ASP A 182
LEU A 183
ASP A 119
SER A 115
THR A  53
 None
 1.50A 1rqpB-5tdxA:
3.0		 1rqpB-5tdxA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 7 ARG A 174
ASP A  37
ILE A  48
GLN A  47
 None
 1.24A 2jc9A-5tdxA:
1.8		 2jc9A-5tdxA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 8 PRO A 212
LYS A 208
SER A 240
ASP A 205
 None
 0.99A 2p02A-5tdxA:
undetectable		 2p02A-5tdxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 5 PHE A  54
PHE A 102
PHE A 189
ILE A  75
 None
 1.19A 2v0mD-5tdxA:
undetectable		 2v0mD-5tdxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 ALA A  90
PRO A 108
GLY A  82
THR A  11
LEU A  88
 None
None
None
GOL  A 300 (-2.9A)
None
 1.02A 2zifA-5tdxA:
undetectable		 2zifA-5tdxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 ALA A  90
PRO A 108
GLY A  82
THR A  11
LEU A  88
 None
None
None
GOL  A 300 (-2.9A)
None
 0.98A 2zifB-5tdxA:
2.0		 2zifB-5tdxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 4 ARG A  46
ASP A  37
ASP A  44
PRO A  45
 None
 1.35A 3fgrB-5tdxA:
undetectable		 3fgrB-5tdxA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 ALA A  87
PHE A  54
ILE A  12
SER A 177
LEU A 106
 None
 1.21A 3nrrA-5tdxA:
undetectable		 3nrrA-5tdxA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 ALA A  87
PHE A  54
ILE A  12
SER A 177
LEU A 106
 None
 1.18A 3nrrB-5tdxA:
undetectable		 3nrrB-5tdxA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 LEU A 245
LEU A  26
VAL A 101
GLY A  78
LEU A   8
 None
 1.09A 3nt1A-5tdxA:
undetectable		 3nt1A-5tdxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 LEU A 106
HIS A  14
GLY A 176
SER A  41
LEU A  84
 None
GOL  A 300 ( 4.6A)
None
None
None
 0.99A 3okxA-5tdxA:
undetectable		 3okxA-5tdxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 LEU A 106
HIS A  14
TYR A  57
SER A  41
LEU A  84
 None
GOL  A 300 ( 4.6A)
None
None
None
 1.26A 3okxA-5tdxA:
undetectable		 3okxA-5tdxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 LEU A 106
HIS A  14
GLY A 176
SER A  41
LEU A  84
 None
GOL  A 300 ( 4.6A)
None
None
None
 0.94A 3okxB-5tdxA:
undetectable		 3okxB-5tdxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 LEU A 106
HIS A  14
TYR A  57
SER A  41
LEU A  84
 None
GOL  A 300 ( 4.6A)
None
None
None
 1.21A 3okxB-5tdxA:
undetectable		 3okxB-5tdxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 7 ILE A  97
GLY A  82
ALA A  89
GLN A 238
 None
 0.94A 4g0uB-5tdxA:
1.2		 4g0uB-5tdxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 SER A  80
CYH A  81
PHE A 178
MET A 146
LEU A 148
 GOL  A 300 (-2.8A)
GOL  A 300 ( 3.7A)
GOL  A 300 ( 4.9A)
None
None
 1.28A 4j7xB-5tdxA:
2.8		 4j7xB-5tdxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 PRO A 108
GLY A  82
ILE A  12
ARG A 186
LEU A 183
 None
 1.28A 4kotA-5tdxA:
undetectable		 4kotA-5tdxA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 12 PRO A 108
GLY A  82
ILE A  12
ARG A 186
LEU A 183
 None
 1.30A 4kovA-5tdxA:
undetectable		 4kovA-5tdxA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		3 / 3 ASP A 207
TRP A 128
SER A  80
 None
None
GOL  A 300 (-2.8A)
 0.96A 4lrhB-5tdxA:
undetectable		 4lrhB-5tdxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		3 / 3 ASP A 207
TRP A 128
SER A  80
 None
None
GOL  A 300 (-2.8A)
 1.04A 4lrhF-5tdxA:
undetectable		 4lrhF-5tdxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 7 PRO A 212
LYS A 208
SER A 240
ASP A 205
 None
 1.01A 4ndnC-5tdxA:
undetectable		 4ndnC-5tdxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		3 / 3 PHE A 189
THR A  11
LEU A 183
 None
GOL  A 300 (-2.9A)
None
 0.67A 4qztA-5tdxA:
undetectable		 4qztA-5tdxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 8 PRO A 212
LYS A 208
SER A 240
ASP A 205
 None
 1.04A 5a1iA-5tdxA:
undetectable		 5a1iA-5tdxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 7 PRO A 212
LYS A 208
SER A 240
ASP A 205
 None
 1.04A 5a1iA-5tdxA:
undetectable		 5a1iA-5tdxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		5 / 8 HIS A  14
SER A 240
HIS A 235
LEU A 237
SER A  80
 GOL  A 300 ( 4.6A)
None
GOL  A 300 (-4.1A)
None
GOL  A 300 (-2.8A)
 1.49A 5m8rB-5tdxA:
undetectable		 5m8rB-5tdxA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 8 PRO A 212
LYS A 208
SER A 240
ASP A 205
 None
 0.91A 6fbnB-5tdxA:
undetectable		 6fbnB-5tdxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 8 PRO A 212
LYS A 208
SER A 240
ASP A 205
 None
 1.07A 6fboA-5tdxA:
undetectable		 6fboA-5tdxA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 8 PRO A 212
LYS A 208
SER A 240
ASP A 205
 None
 1.06A 6fcdA-5tdxA:
undetectable		 6fcdA-5tdxA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 7 PRO A 212
LYS A 208
SER A 240
ASP A 205
 None
 1.05A 6g6rA-5tdxA:
undetectable		 6g6rA-5tdxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 6 PRO A  60
ILE A  51
TYR A  57
GLU A  56
 None
 0.82A 6gqiA-5tdxA:
2.0		 6gqiA-5tdxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1
(synthetic
construct) 		4 / 8 TYR A  57
ASN A  85
PHE A  54
SER A 177
 None
 1.12A 6huoC-5tdxA:
undetectable
6huoD-5tdxA:
undetectable		 6huoC-5tdxA:
15.81
6huoD-5tdxA:
14.29