SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5te4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5te4 HIV-1 CLADE G STRAIN
X2088 GP120
(Human
immunodeficiency
virus
1) 		4 / 8 SER G  56
SER G 115
PHE G 210
ILE G 108
 None
 0.99A 1gm7A-5te4G:
undetectable
1gm7B-5te4G:
undetectable		 1gm7A-5te4G:
22.07
1gm7B-5te4G:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5te4 HIV-1 CLADE G STRAIN
X2088 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 GLY G 366
ALA G 365
SER G 388
HIS G 374
GLU G 370
 None
None
NAG  G 508 (-3.3A)
None
None
 1.45A 3s8pA-5te4G:
undetectable		 3s8pA-5te4G:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5te4 HIV-1 CLADE G STRAIN
X2088 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 GLY G 366
ALA G 365
SER G 388
HIS G 374
GLU G 370
 None
None
NAG  G 508 (-3.3A)
None
None
 1.46A 3s8pB-5te4G:
undetectable		 3s8pB-5te4G:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5te4 HIV-1 CLADE G STRAIN
X2088 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 SER G 375
PHE G 382
LYS G 421
 BU3  G 515 (-3.2A)
None
SO4  G 512 (-2.8A)
 1.00A 3u88A-5te4G:
undetectable		 3u88A-5te4G:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5te4 HIV-1 CLADE G STRAIN
X2088 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE G 270
VAL G 286
ILE G 449
TRP G 338
ILE G 341
 None
 0.85A 3vrjA-5te4G:
undetectable
3vrjC-5te4G:
undetectable		 3vrjA-5te4G:
20.66
3vrjC-5te4G:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5te4 HIV-1 CLADE G STRAIN
X2088 GP120
(Human
immunodeficiency
virus
1) 		4 / 7 THR G 387
LEU G 288
GLN G 348
LEU G 349
 None
 1.06A 4ib4A-5te4G:
undetectable		 4ib4A-5te4G:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5te4 HIV-1 CLADE G STRAIN
X2088 GP120
(Human
immunodeficiency
virus
1) 		5 / 11 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 1.14A 4p66A-5te4G:
undetectable		 4p66A-5te4G:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5te4 HIV-1 CLADE G STRAIN
X2088 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 TYR G 486
LYS G 485
LYS G 227
 None
 1.32A 5dbyA-5te4G:
undetectable		 5dbyA-5te4G:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5te4 HIV-1 CLADE G STRAIN
X2088 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 GLY G 366
ILE G 341
GLY G 451
LEU G 454
THR G 372
 None
 1.25A 6e8qA-5te4G:
undetectable		 6e8qA-5te4G:
11.01