SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ted'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 6 PRO B 217
LEU B 205
ILE B 206
SER B 200
 None
None
None
SKM  B 401 (-2.8A)
 1.11A 1sbrA-5tedB:
undetectable
1sbrB-5tedB:
undetectable		 1sbrA-5tedB:
18.53
1sbrB-5tedB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		5 / 11 SER B 200
VAL B 223
GLU B 224
ILE B 194
ARG B 265
 SKM  B 401 (-2.8A)
None
None
None
SKM  B 401 (-3.4A)
 1.42A 1vhwA-5tedB:
undetectable
1vhwD-5tedB:
undetectable		 1vhwA-5tedB:
24.64
1vhwD-5tedB:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		5 / 11 SER B 200
VAL B 223
GLU B 224
ILE B 194
ARG B 265
 SKM  B 401 (-2.8A)
None
None
None
SKM  B 401 (-3.4A)
 1.42A 1vhwC-5tedB:
undetectable
1vhwE-5tedB:
undetectable		 1vhwC-5tedB:
24.64
1vhwE-5tedB:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ARG B 265
SER B 200
VAL B 223
GLU B 224
ILE B 194
 SKM  B 401 (-3.4A)
SKM  B 401 (-2.8A)
None
None
None
 1.42A 1vhwA-5tedB:
undetectable
1vhwD-5tedB:
undetectable		 1vhwA-5tedB:
24.64
1vhwD-5tedB:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 7 SER B 208
LEU B 205
GLY B 201
THR B 131
 None
None
SKM  B 401 (-3.3A)
SKM  B 401 (-3.3A)
 0.94A 2bdmA-5tedB:
undetectable		 2bdmA-5tedB:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 5 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 0.95A 2y69P-5tedB:
undetectable
2y69W-5tedB:
undetectable		 2y69P-5tedB:
20.60
2y69W-5tedB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		5 / 11 LEU B  95
LEU B 138
ALA B 146
LEU B 269
LYS B 273
 None
 1.30A 3e22B-5tedB:
undetectable		 3e22B-5tedB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		5 / 12 VAL B 255
LEU B 177
ILE B 258
ILE B 206
LEU B 202
 None
None
None
None
SKM  B 401 (-3.6A)
 1.00A 3w67D-5tedB:
undetectable		 3w67D-5tedB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 7 ILE B 215
GLN B 186
PRO B 261
ILE B 258
 None
 1.07A 4z4eA-5tedB:
undetectable		 4z4eA-5tedB:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASP B 286
GLU B 158
SER B  89
 None
 0.80A 5bw4B-5tedB:
undetectable		 5bw4B-5tedB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 7 ILE B 219
PHE B 195
ASP B 198
SER B 200
 None
None
None
SKM  B 401 (-2.8A)
 0.97A 5nr3A-5tedB:
undetectable		 5nr3A-5tedB:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 5 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 1.00A 5wauc-5tedB:
undetectable
5wauj-5tedB:
undetectable		 5wauc-5tedB:
20.60
5wauj-5tedB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 5 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 1.00A 5xdqC-5tedB:
undetectable
5xdqJ-5tedB:
undetectable		 5xdqC-5tedB:
20.60
5xdqJ-5tedB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 5 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 1.02A 5xdqP-5tedB:
undetectable
5xdqW-5tedB:
undetectable		 5xdqP-5tedB:
20.60
5xdqW-5tedB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 6 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 0.98A 5z84P-5tedB:
undetectable
5z84W-5tedB:
undetectable		 5z84P-5tedB:
20.60
5z84W-5tedB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 6 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 0.99A 5z85P-5tedB:
undetectable
5z85W-5tedB:
undetectable		 5z85P-5tedB:
20.60
5z85W-5tedB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 6 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 0.99A 5z86C-5tedB:
undetectable
5z86J-5tedB:
undetectable		 5z86C-5tedB:
20.60
5z86J-5tedB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 6 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 1.00A 5z86P-5tedB:
undetectable
5z86W-5tedB:
undetectable		 5z86P-5tedB:
20.60
5z86W-5tedB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 6 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 1.02A 5zcoP-5tedB:
undetectable
5zcoW-5tedB:
undetectable		 5zcoP-5tedB:
20.60
5zcoW-5tedB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 6 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 1.00A 5zcpC-5tedB:
undetectable
5zcpJ-5tedB:
undetectable		 5zcpC-5tedB:
20.60
5zcpJ-5tedB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ted LMO0488 PROTEIN
(Listeria
monocytogenes) 		4 / 6 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 0.96A 5zcpP-5tedB:
undetectable
5zcpW-5tedB:
undetectable		 5zcpP-5tedB:
20.60
5zcpW-5tedB:
12.39