SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5teg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.80A 1n6cA-5tegA:
12.8
1n6cA-5tegA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 229
LEU A 293
GLY A 217
ALA A 232
ALA A 327
None
1.07A 2bm9F-5tegA:
undetectable
2bm9F-5tegA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
4 / 7 LEU A 320
LEU A 332
ILE A 223
TYR A 336
None
None
None
SAM  A 401 (-4.8A)
1.16A 2hc4A-5tegA:
undetectable
2hc4A-5tegA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.35A 3ooiA-5tegA:
15.2
3ooiA-5tegA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
6 / 12 LYS A 226
GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.46A 3opeA-5tegA:
14.6
3opeA-5tegA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 9 LYS A 226
GLY A 227
TYR A 271
ASN A 298
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
SAM  A 401 (-4.8A)
0.91A 3opeB-5tegA:
14.8
3opeB-5tegA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.86A 3qxyA-5tegA:
7.5
3qxyA-5tegA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.82A 3rc0B-5tegA:
7.2
3rc0B-5tegA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7B_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 LYS A 226
ARG A 228
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.77A 3s7bA-5tegA:
8.3
3s7bA-5tegA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7F_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2
P53 PEPTIDE)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 LYS A 226
ARG A 228
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.81A 3s7fA-5tegA:
7.1
3s7fI-5tegA:
undetectable
3s7fA-5tegA:
16.40
3s7fI-5tegA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7J_A_SAMA1000_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 LYS A 226
ARG A 228
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.79A 3s7jA-5tegA:
7.7
3s7jA-5tegA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TG4_A_SAMA434_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 10 LYS A 226
ARG A 228
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.74A 3tg4A-5tegA:
7.2
3tg4A-5tegA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.85A 4e47A-5tegA:
13.5
4e47A-5tegA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.88A 4e47B-5tegA:
11.1
4e47B-5tegA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.91A 4e47C-5tegA:
13.0
4e47C-5tegA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
8 / 10 LYS A 226
ARG A 228
TYR A 271
LEU A 296
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.1A)
SAM  A 401 (-4.6A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.48A 4ij8A-5tegA:
23.4
4ij8B-5tegA:
22.3
4ij8A-5tegA:
100.00
4ij8B-5tegA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IJ8_B_SAMB501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
7 / 9 LYS A 226
ARG A 228
TYR A 271
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.49A 4ij8A-5tegA:
23.4
4ij8B-5tegA:
22.3
4ij8A-5tegA:
100.00
4ij8B-5tegA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.86A 4jdsA-5tegA:
13.2
4jdsA-5tegA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.86A 4jdsB-5tegA:
13.4
4jdsB-5tegA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.91A 4jdsC-5tegA:
13.2
4jdsC-5tegA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.81A 4jlgA-5tegA:
13.2
4jlgA-5tegA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YND_A_SAMA505_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 10 LYS A 226
ARG A 228
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.67A 4yndA-5tegA:
7.9
4yndA-5tegA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 LYS A 226
GLY A 227
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.28A 4ynmA-5tegA:
14.2
4ynmA-5tegA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 LYS A 226
GLY A 227
HIS A 347
ASN A 298
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
None
SAM  A 401 (-3.2A)
SAM  A 401 (-4.8A)
1.30A 4ynmA-5tegA:
14.2
4ynmA-5tegA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.29A 4ynmB-5tegA:
15.2
4ynmB-5tegA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 LYS A 226
GLY A 227
TYR A 271
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
None
SAM  A 401 (-4.8A)
0.44A 4ynpA-5tegA:
14.2
4ynpA-5tegA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 10 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.50A 4ynpB-5tegA:
15.3
4ynpB-5tegA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
6 / 12 LYS A 226
GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.27A 4ypaA-5tegA:
14.3
4ypaA-5tegA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 LYS A 226
GLY A 227
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.25A 4ypaB-5tegA:
14.5
4ypaB-5tegA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 LYS A 226
GLY A 227
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.16A 4ypaC-5tegA:
14.5
4ypaC-5tegA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 LYS A 226
GLY A 227
HIS A 347
ASN A 298
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
None
SAM  A 401 (-3.2A)
SAM  A 401 (-4.8A)
1.27A 4ypaC-5tegA:
14.5
4ypaC-5tegA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
6 / 12 LYS A 226
GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.32A 4ypaD-5tegA:
14.5
4ypaD-5tegA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
6 / 12 LYS A 226
GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.27A 4ypeA-5tegA:
13.8
4ypeA-5tegA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
6 / 11 LYS A 226
GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.31A 4ypeB-5tegA:
14.7
4ypeB-5tegA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 LYS A 226
GLY A 227
HIS A 347
ASN A 298
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
None
SAM  A 401 (-3.2A)
SAM  A 401 (-4.8A)
1.37A 4ypuA-5tegA:
14.0
4ypuA-5tegA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
6 / 12 LYS A 226
GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.38A 4ypuA-5tegA:
14.0
4ypuA-5tegA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
6 / 11 LYS A 226
GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.43A 4ypuB-5tegA:
15.1
4ypuB-5tegA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 LYS A 226
GLY A 227
ARG A 228
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.7A)
None
SAM  A 401 (-4.8A)
0.78A 5arfA-5tegA:
7.1
5arfA-5tegA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARG_A_SAMA1434_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 LYS A 226
ARG A 228
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.91A 5argA-5tegA:
7.5
5argA-5tegA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.49A 5ayfA-5tegA:
12.7
5ayfA-5tegA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.22A 5jhnA-5tegA:
12.9
5jhnA-5tegA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.21A 5jhnB-5tegA:
12.7
5jhnB-5tegA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.18A 5jiyA-5tegA:
12.6
5jiyA-5tegA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.19A 5jiyB-5tegA:
12.6
5jiyB-5tegA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KJK_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 LYS A 226
ARG A 228
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.78A 5kjkA-5tegA:
0.0
5kjkA-5tegA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KJL_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 LYS A 226
ARG A 228
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.71A 5kjlA-5tegA:
7.5
5kjlA-5tegA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KJM_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 LYS A 226
ARG A 228
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.79A 5kjmA-5tegA:
8.3
5kjmA-5tegA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.20A 5t0kA-5tegA:
12.8
5t0kA-5tegA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.18A 5t0mB-5tegA:
12.7
5t0mB-5tegA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
8 / 9 LYS A 226
ARG A 228
TYR A 271
LEU A 296
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.1A)
SAM  A 401 (-4.6A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.00A 5tegA-5tegA:
30.7
5tegD-5tegA:
undetectable
5tegA-5tegA:
100.00
5tegD-5tegA:
4.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
9 / 10 LYS A 226
GLY A 227
ARG A 228
TYR A 271
LEU A 296
ASN A 298
HIS A 299
TYR A 336
TRP A 349
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.1A)
SAM  A 401 (-4.6A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
0.14A 5tegB-5tegA:
28.0
5tegE-5tegA:
undetectable
5tegB-5tegA:
100.00
5tegE-5tegA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 10 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.38A 5tqrB-5tegA:
10.3
5tqrB-5tegA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.21A 5ttfA-5tegA:
12.6
5ttfA-5tegA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.19A 5ttfB-5tegA:
12.6
5ttfB-5tegA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.25A 5ttfD-5tegA:
13.1
5ttfD-5tegA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.23A 5ttgA-5tegA:
13.9
5ttgA-5tegA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.27A 5ttgB-5tegA:
13.7
5ttgB-5tegA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.19A 5tuyA-5tegA:
13.0
5tuyA-5tegA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.20A 5tuyB-5tegA:
13.0
5tuyB-5tegA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.23A 5tuzB-5tegA:
13.6
5tuzB-5tegA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.23A 5updA-5tegA:
15.3
5updA-5tegA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
6 / 12 LYS A 226
GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.42A 5v21A-5tegA:
14.5
5v21A-5tegA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3H_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 10 LYS A 226
ARG A 228
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.75A 5v3hA-5tegA:
8.0
5v3hA-5tegA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.22A 5v9iA-5tegA:
12.5
5v9iA-5tegA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.20A 5v9iB-5tegA:
12.5
5v9iB-5tegA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.26A 5v9iC-5tegA:
12.5
5v9iC-5tegA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.24A 5v9jA-5tegA:
14.0
5v9jA-5tegA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.26A 5v9jB-5tegA:
13.7
5v9jB-5tegA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.19A 5vscA-5tegA:
12.6
5vscA-5tegA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.19A 5vscB-5tegA:
12.8
5vscB-5tegA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.28A 5vsdB-5tegA:
13.9
5vsdB-5tegA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.18A 5vseA-5tegA:
12.8
5vseA-5tegA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.19A 5vseB-5tegA:
12.5
5vseB-5tegA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.21A 5vsfB-5tegA:
14.0
5vsfB-5tegA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.52A 6a5mA-5tegA:
11.6
6a5mA-5tegA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.99A 6agoA-5tegA:
13.6
6agoA-5tegA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 LYS A 226
GLY A 227
TYR A 271
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
None
SAM  A 401 (-4.8A)
0.47A 6bp4B-5tegA:
12.0
6bp4B-5tegA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 11 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.24A 6cenA-5tegA:
15.2
6cenA-5tegA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo
sapiens)
5 / 12 LYS A 226
GLY A 227
ASN A 298
HIS A 299
TYR A 336
SAM  A 401 (-4.6A)
SAM  A 401 ( 4.0A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
0.37A 6ineA-5tegA:
13.6
6ineA-5tegA:
20.97