SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		4 / 5 PHE C 239
GLY C 214
SER C 164
THR C 166
 NAD  C1001 ( 4.0A)
None
PDC  C1002 (-4.2A)
PDC  C1002 (-3.7A)
 1.38A 1icuC-5temC:
undetectable
1icuD-5temC:
undetectable		 1icuC-5temC:
24.38
1icuD-5temC:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		4 / 5 PHE C 239
GLY C 214
SER C 164
THR C 166
 NAD  C1001 ( 4.0A)
None
PDC  C1002 (-4.2A)
PDC  C1002 (-3.7A)
 1.31A 1icvA-5temC:
undetectable
1icvB-5temC:
undetectable		 1icvA-5temC:
24.38
1icvB-5temC:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 PHE C 257
VAL C 119
ILE C  95
PHE C  75
TYR C 125
 None
None
None
NAD  C1001 (-4.5A)
NAD  C1001 (-4.8A)
 1.48A 3apwA-5temC:
undetectable		 3apwA-5temC:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		5 / 10 ALA C  30
ALA C  31
GLN C  68
VAL C  96
ILE C  95
 None
 1.05A 3falA-5temC:
undetectable		 3falA-5temC:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		4 / 5 ILE C 168
HIS C 216
GLU C 153
HIS C 155
 None
None
None
PDC  C1002 ( 4.4A)
 0.98A 3ljgA-5temC:
2.7		 3ljgA-5temC:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		4 / 6 HIS C 216
ARG C 208
HIS C 155
ASP C 161
 None
None
PDC  C1002 ( 4.4A)
NAD  C1001 ( 3.9A)
 1.12A 3nvcA-5temC:
undetectable		 3nvcA-5temC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 ASP C 200
ASP C 148
ILE C 202
GLY C 144
VAL C 185
 None
 1.05A 3ucbA-5temC:
undetectable		 3ucbA-5temC:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		5 / 9 VAL C   6
GLY C  42
VAL C  41
GLU C  34
ASP C  44
 None
None
None
NAD  C1001 (-2.9A)
None
 1.35A 5zniA-5temC:
2.6		 5zniA-5temC:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		5 / 10 GLY C   8
GLY C  11
SER C  33
GLU C  34
THR C  76
 NAD  C1001 (-3.4A)
NAD  C1001 (-3.3A)
NAD  C1001 (-3.4A)
NAD  C1001 (-2.9A)
NAD  C1001 (-3.8A)
 0.55A 6exiA-5temC:
8.1		 6exiA-5temC:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		5 / 10 GLY C   8
GLY C  11
SER C  33
GLU C  34
THR C  76
 NAD  C1001 (-3.4A)
NAD  C1001 (-3.3A)
NAD  C1001 (-3.4A)
NAD  C1001 (-2.9A)
NAD  C1001 (-3.8A)
 0.53A 6exiB-5temC:
8.0		 6exiB-5temC:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 GLY C   8
GLY C  11
SER C  33
GLU C  34
THR C  76
 NAD  C1001 (-3.4A)
NAD  C1001 (-3.3A)
NAD  C1001 (-3.4A)
NAD  C1001 (-2.9A)
NAD  C1001 (-3.8A)
 0.53A 6exiC-5temC:
7.4
6exiD-5temC:
7.5		 6exiC-5temC:
15.47
6exiD-5temC:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 GLY C   8
GLY C  11
SER C  33
GLU C  34
THR C  76
 NAD  C1001 (-3.4A)
NAD  C1001 (-3.3A)
NAD  C1001 (-3.4A)
NAD  C1001 (-2.9A)
NAD  C1001 (-3.8A)
 0.56A 6exiC-5temC:
7.5
6exiD-5temC:
7.4		 6exiC-5temC:
15.47
6exiD-5temC:
15.47