SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tf2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  82
GLY A  32
PHE A  14
HIS A  46
PHE A  47
 None
 1.23A 1brpA-5tf2A:
undetectable		 1brpA-5tf2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 ALA A 368
TYR A 336
ILE A 326
LEU A 382
 None
 1.04A 1xvaA-5tf2A:
undetectable
1xvaB-5tf2A:
undetectable		 1xvaA-5tf2A:
20.24
1xvaB-5tf2A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 5 THR A 367
SER A 309
PRO A 353
SER A 311
 None
 1.47A 2hdnA-5tf2A:
undetectable
2hdnB-5tf2A:
undetectable
2hdnD-5tf2A:
undetectable		 2hdnA-5tf2A:
6.41
2hdnB-5tf2A:
22.45
2hdnD-5tf2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 5 SER A 311
THR A 367
SER A 309
PRO A 353
 None
 1.40A 2hdnB-5tf2A:
undetectable
2hdnC-5tf2A:
undetectable
2hdnD-5tf2A:
undetectable		 2hdnB-5tf2A:
22.45
2hdnC-5tf2A:
6.41
2hdnD-5tf2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 SER A 304
THR A 347
ALA A 373
ASP A 375
ARG A 377
 None
 1.47A 2qm9A-5tf2A:
undetectable		 2qm9A-5tf2A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 7 TYR A 245
VAL A 302
TYR A 281
CYH A 298
 None
 1.15A 2xz5B-5tf2A:
undetectable
2xz5E-5tf2A:
undetectable		 2xz5B-5tf2A:
17.97
2xz5E-5tf2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 245
VAL A 302
TYR A 281
CYH A 298
 None
 1.12A 2xz5A-5tf2A:
undetectable
2xz5C-5tf2A:
undetectable		 2xz5A-5tf2A:
17.97
2xz5C-5tf2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 245
VAL A 302
TYR A 281
CYH A 298
 None
 1.12A 2xz5C-5tf2A:
undetectable
2xz5D-5tf2A:
undetectable		 2xz5C-5tf2A:
17.97
2xz5D-5tf2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 7 TYR A 245
VAL A 302
TYR A 281
CYH A 298
 None
 1.13A 2xz5D-5tf2A:
undetectable
2xz5E-5tf2A:
undetectable		 2xz5D-5tf2A:
17.97
2xz5E-5tf2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 PHE A  14
THR A  67
ALA A  30
ALA A  31
 None
 1.17A 3ns1C-5tf2A:
undetectable		 3ns1C-5tf2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		5 / 10 GLY A 318
ALA A 341
VAL A 324
SER A 304
VAL A 349
 None
 1.03A 4da7A-5tf2A:
undetectable		 4da7A-5tf2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 7 GLY A  26
ILE A  29
LEU A  77
PHE A  95
 None
 0.89A 4ejjD-5tf2A:
undetectable		 4ejjD-5tf2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		6 / 12 LEU A  93
LEU A  82
LEU A  77
ALA A  76
ALA A  18
CYH A  90
 None
 1.30A 4fn9A-5tf2A:
undetectable		 4fn9A-5tf2A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 ILE A  41
ASP A  66
GLY A  32
HIS A  65
 None
 1.00A 4oltA-5tf2A:
undetectable		 4oltA-5tf2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 382
LEU A 380
ALA A 368
LEU A  50
LEU A 362
 None
 1.27A 4p65A-5tf2A:
undetectable
4p65B-5tf2A:
undetectable
4p65F-5tf2A:
undetectable
4p65H-5tf2A:
undetectable		 4p65A-5tf2A:
6.40
4p65B-5tf2A:
5.59
4p65F-5tf2A:
5.59
4p65H-5tf2A:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 5 THR A 283
THR A 266
THR A 229
HIS A 232
 None
 1.37A 4pgfB-5tf2A:
undetectable		 4pgfB-5tf2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 SER A  64
ILE A  41
LEU A  48
LEU A  61
TYR A  10
 None
 1.32A 4xumA-5tf2A:
undetectable		 4xumA-5tf2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5H_A_ACTA1229_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 4 VAL A 338
GLU A 340
THR A 321
GLU A 301
 None
 1.48A 5g5hA-5tf2A:
undetectable		 5g5hA-5tf2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 HIS A 381
LEU A 369
CYH A 378
LEU A  19
 None
 1.47A 5hrqD-5tf2A:
undetectable
5hrqG-5tf2A:
undetectable
5hrqH-5tf2A:
undetectable		 5hrqD-5tf2A:
5.59
5hrqG-5tf2A:
6.40
5hrqH-5tf2A:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 ASN A  74
GLN A  20
THR A 174
GLY A 172
THR A 171
 None
 1.44A 5oj0A-5tf2A:
undetectable		 5oj0A-5tf2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		5 / 11 GLU A 354
GLU A 366
GLY A 316
ASP A 307
VAL A 349
 None
 1.05A 5yk2A-5tf2A:
undetectable		 5yk2A-5tf2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 ASP A 307
LEU A 369
ALA A 368
GLY A  26
LEU A  50
 None
 1.08A 6b0iB-5tf2A:
undetectable		 6b0iB-5tf2A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		4 / 7 ARG A  94
LEU A  93
ALA A  84
GLN A  96
 None
 1.26A 6b89A-5tf2A:
undetectable		 6b89A-5tf2A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens) 		5 / 10 THR A 347
ASP A 375
GLY A 343
GLY A 322
GLU A 340
 None
 1.33A 6nqaK-5tf2A:
undetectable		 6nqaK-5tf2A:
20.13