SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5tf4 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Bartonella
henselae) 		4 / 5 SER A 139
GLY A 142
ASP A 230
ASP A 238
 None
 1.14A 2oxtB-5tf4A:
5.5		 2oxtB-5tf4A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 5tf4 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Bartonella
henselae) 		5 / 11 SER A 123
LEU A 104
ALA A 199
THR A 197
GLU A 170
 None
None
NAD  A 300 (-3.2A)
NAD  A 300 (-2.8A)
None
 1.24A 2v0mD-5tf4A:
undetectable		 2v0mD-5tf4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 5tf4 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Bartonella
henselae) 		4 / 6 VAL A  78
LEU A 130
CYH A  67
SER A  74
 None
 1.26A 3b6rB-5tf4A:
undetectable		 3b6rB-5tf4A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5tf4 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Bartonella
henselae) 		5 / 12 LEU A  92
ILE A  15
GLY A  17
ALA A  95
LEU A 147
 None
None
NAD  A 300 (-3.4A)
NAD  A 300 (-4.0A)
NAD  A 300 (-3.6A)
 1.21A 3n8xA-5tf4A:
undetectable		 3n8xA-5tf4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5tf4 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Bartonella
henselae) 		5 / 12 LEU A  92
PHE A  79
ILE A  82
ALA A  40
LEU A  39
 None
 1.17A 3n8xA-5tf4A:
undetectable		 3n8xA-5tf4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5tf4 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Bartonella
henselae) 		5 / 12 LEU A  92
PHE A  79
ILE A  82
ALA A  40
LEU A  39
 None
 1.11A 3n8xB-5tf4A:
undetectable		 3n8xB-5tf4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5tf4 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Bartonella
henselae) 		5 / 12 TYR A 150
SER A 191
GLY A 253
ALA A 217
GLU A 153
 None
 1.31A 5wbvA-5tf4A:
undetectable		 5wbvA-5tf4A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5tf4 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Bartonella
henselae) 		5 / 12 TYR A 150
SER A 191
GLY A 253
ALA A 217
GLU A 153
 None
 1.31A 5wbvB-5tf4A:
undetectable		 5wbvB-5tf4A:
23.57