SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 5tfm CADHERIN-23
(Homo
sapiens) 		3 / 3 ASP A 727
TYR A 681
GLU A 607
 CA  A 901 (-3.5A)
None
CA  A 902 ( 2.2A)
 0.86A 1vm1A-5tfmA:
undetectable		 1vm1A-5tfmA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 5tfm CADHERIN-23
(Homo
sapiens) 		4 / 6 THR A 806
VAL A 791
GLU A 786
CYH A 840
 None
 1.11A 3b6rB-5tfmA:
undetectable		 3b6rB-5tfmA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5tfm CADHERIN-23
(Homo
sapiens) 		4 / 6 PHE A 696
TYR A 719
LEU A 745
VAL A 657
 None
 1.03A 4ek1A-5tfmA:
undetectable		 4ek1A-5tfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5tfm CADHERIN-23
(Homo
sapiens) 		4 / 6 ASN A 550
GLU A 551
TYR A 606
GLU A 641
 CA  A 903 ( 3.8A)
None
None
None
 1.36A 4r87H-5tfmA:
undetectable		 4r87H-5tfmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5tfm CADHERIN-23
(Homo
sapiens) 		4 / 6 LEU A 817
LEU A 829
PHE A 800
ILE A 810
 None
 1.19A 4y4dA-5tfmA:
undetectable		 4y4dA-5tfmA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5tfm CADHERIN-23
(Homo
sapiens) 		4 / 6 SER A 581
GLY A 612
ASN A 611
ILE A 636
 None
 0.97A 5j4nA-5tfmA:
undetectable		 5j4nA-5tfmA:
9.21