SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tgd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 12 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.53A 1e7wA-5tgdA:
30.7		 1e7wA-5tgdA:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 11 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.56A 1e7wB-5tgdA:
30.1		 1e7wB-5tgdA:
31.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 12 GLU A 228
ASP A 155
ILE A  32
ALA A  35
THR A 232
 None
NAP  A 301 ( 3.8A)
NAP  A 301 (-3.7A)
None
None
 1.28A 1kijB-5tgdA:
undetectable		 1kijB-5tgdA:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 11 ARG A  31
SER A 105
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
NAP  A 301 ( 3.8A)
None
None
 0.55A 1mxfB-5tgdA:
31.8		 1mxfB-5tgdA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 11 ARG A  31
SER A 105
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
NAP  A 301 ( 3.8A)
None
None
 0.53A 1mxfC-5tgdA:
31.9		 1mxfC-5tgdA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 11 ARG A  31
SER A 105
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
NAP  A 301 ( 3.8A)
None
None
 0.55A 1mxfD-5tgdA:
31.9		 1mxfD-5tgdA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 12 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.44A 1p33A-5tgdA:
31.2		 1p33A-5tgdA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 12 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.42A 1p33B-5tgdA:
31.0		 1p33B-5tgdA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 12 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.41A 1p33C-5tgdA:
31.3		 1p33C-5tgdA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 12 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.47A 1p33D-5tgdA:
30.8		 1p33D-5tgdA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 8 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.50A 2bfpA-5tgdA:
30.5		 2bfpA-5tgdA:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 8 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.48A 2bfpD-5tgdA:
30.2		 2bfpD-5tgdA:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C7V_A_MTXA1272_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 9 ARG A  31
SER A 105
PHE A 107
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
None
None
 0.61A 2c7vA-5tgdA:
32.2		 2c7vA-5tgdA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C7V_B_MTXB1272_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		6 / 12 ARG A  31
SER A 105
PHE A 107
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
None
 0.69A 2c7vB-5tgdA:
32.1		 2c7vB-5tgdA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		6 / 12 ARG A  31
SER A 105
PHE A 107
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
None
 0.65A 2c7vC-5tgdA:
31.9		 2c7vC-5tgdA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C7V_D_MTXD1272_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		6 / 10 ARG A  31
SER A 105
PHE A 107
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
None
 0.67A 2c7vD-5tgdA:
32.2		 2c7vD-5tgdA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		4 / 5 LEU A 100
ASN A 102
VAL A 192
ALA A 135
 None
 1.16A 2cizA-5tgdA:
undetectable		 2cizA-5tgdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		3 / 3 LYS A 172
GLY A 198
PRO A 199
 NAP  A 301 (-2.6A)
NAP  A 301 (-4.6A)
None
 1.03A 2hreB-5tgdA:
3.0		 2hreB-5tgdA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		4 / 6 LEU A 182
ILE A 190
VAL A 150
ALA A 135
 None
 1.09A 2j5mA-5tgdA:
undetectable		 2j5mA-5tgdA:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_A_LYAA1270_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		6 / 12 ARG A  31
SER A 105
PHE A 107
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
None
 0.67A 2x9gA-5tgdA:
32.5		 2x9gA-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_B_LYAB1270_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		6 / 12 ARG A  31
SER A 105
PHE A 107
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
None
 0.69A 2x9gB-5tgdA:
32.0		 2x9gB-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_C_LYAC1270_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		6 / 12 ARG A  31
SER A 105
PHE A 107
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
None
 0.65A 2x9gC-5tgdA:
32.4		 2x9gC-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9G_D_LYAD1270_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		6 / 12 ARG A  31
SER A 105
PHE A 107
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
None
 0.68A 2x9gD-5tgdA:
32.2		 2x9gD-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9V_A_TMQA1270_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 11 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.41A 2x9vA-5tgdA:
32.3		 2x9vA-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9V_B_TMQB1270_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 9 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.44A 2x9vB-5tgdA:
32.0		 2x9vB-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9V_C_TMQC1270_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		6 / 10 ARG A  31
SER A 105
PHE A 107
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
None
 0.61A 2x9vC-5tgdA:
32.4		 2x9vC-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X9V_D_TMQD1270_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 9 SER A 105
PHE A 107
ASP A 155
PHE A 165
TYR A 168
 NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
None
 0.62A 2x9vD-5tgdA:
32.2		 2x9vD-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BMC_A_FOLA270_0
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 11 ARG A  31
SER A 105
PHE A 107
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
None
None
 0.54A 3bmcA-5tgdA:
32.4		 3bmcA-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BMC_B_FOLB270_0
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 11 ARG A  31
SER A 105
PHE A 107
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
None
None
 0.53A 3bmcB-5tgdA:
32.3		 3bmcB-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BMC_C_FOLC270_0
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 12 ARG A  31
SER A 105
PHE A 107
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
None
None
 0.53A 3bmcC-5tgdA:
32.3		 3bmcC-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BMC_D_FOLD270_0
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 12 ARG A  31
SER A 105
PHE A 107
PHE A 165
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
None
None
 0.53A 3bmcD-5tgdA:
32.4		 3bmcD-5tgdA:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 12 ILE A 154
ASP A 155
GLN A 156
ALA A 196
ILE A 247
 None
NAP  A 301 ( 3.8A)
None
None
None
 1.25A 3ddyA-5tgdA:
undetectable		 3ddyA-5tgdA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 12 LEU A 149
GLY A 148
LEU A  99
ARG A  98
PHE A  45
 None
 1.10A 3gwwA-5tgdA:
undetectable		 3gwwA-5tgdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 12 ILE A  32
GLY A  33
PHE A 229
ALA A 104
ASN A 102
 NAP  A 301 (-3.7A)
None
None
NAP  A 301 (-3.3A)
None
 0.85A 3jb3A-5tgdA:
5.2		 3jb3A-5tgdA:
13.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQ7_A_DX2A271_1
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 10 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.51A 3jq7A-5tgdA:
32.3		 3jq7A-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 8 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.52A 3jq7B-5tgdA:
32.1		 3jq7B-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQ7_D_DX2D270_1
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 9 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.49A 3jq7D-5tgdA:
32.2		 3jq7D-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 6 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.51A 3jqaA-5tgdA:
32.2		 3jqaA-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 6 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.53A 3jqaB-5tgdA:
31.9		 3jqaB-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 6 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.49A 3jqaC-5tgdA:
32.4		 3jqaC-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 6 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.47A 3jqaD-5tgdA:
32.2		 3jqaD-5tgdA:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 9 ASP A  39
VAL A  47
ALA A  72
SER A  42
GLY A  70
 None
 1.38A 4mmfA-5tgdA:
undetectable		 4mmfA-5tgdA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		3 / 3 GLY A  95
PRO A  96
ALA A 141
 None
 0.44A 4qn9B-5tgdA:
2.4		 4qn9B-5tgdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		4 / 4 ARG A  16
ARG A 191
LEU A 149
ASN A 239
 None
 1.14A 5cu6A-5tgdA:
0.0		 5cu6A-5tgdA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVF_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		4 / 4 ARG A  16
ARG A 191
LEU A 149
ASN A 239
 None
 1.17A 5cvfA-5tgdA:
0.0		 5cvfA-5tgdA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JDC_A_6JPA302_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 10 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.52A 5jdcA-5tgdA:
32.3
5jdcD-5tgdA:
32.5		 5jdcA-5tgdA:
31.65
5jdcD-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JDC_B_6JPB302_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 9 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.56A 5jdcB-5tgdA:
32.0		 5jdcB-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JDC_C_6JPC302_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 10 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.54A 5jdcB-5tgdA:
32.0
5jdcC-5tgdA:
30.9		 5jdcB-5tgdA:
31.65
5jdcC-5tgdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		5 / 11 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.52A 5jdcA-5tgdA:
32.3
5jdcD-5tgdA:
32.5		 5jdcA-5tgdA:
31.65
5jdcD-5tgdA:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		4 / 5 ILE A  94
ILE A  49
HIS A  50
VAL A  75
 None
None
NAP  A 301 (-4.5A)
None
 0.91A 5jmnA-5tgdA:
undetectable		 5jmnA-5tgdA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		4 / 4 ARG A  16
ARG A 191
LEU A 149
ASN A 239
 None
 1.14A 5ospA-5tgdA:
0.0		 5ospA-5tgdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		4 / 5 ARG A  16
ARG A 191
LEU A 149
ASN A 239
 None
 1.14A 5otrA-5tgdA:
undetectable		 5otrA-5tgdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		4 / 7 ASP A 116
ALA A 114
LYS A 111
GLU A 109
 None
 1.07A 6ci6A-5tgdA:
undetectable		 6ci6A-5tgdA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		4 / 4 HIS A  50
VAL A  83
LEU A  79
ALA A  77
 NAP  A 301 (-4.5A)
EDO  A 302 ( 4.8A)
NAP  A 301 ( 3.7A)
None
 1.43A 6d8pB-5tgdA:
2.0		 6d8pB-5tgdA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE
(Brucella
suis) 		4 / 6 LEU A  99
CYH A  21
GLY A 148
ARG A  16
 None
 1.33A 6gtqB-5tgdA:
undetectable
6gtqD-5tgdA:
undetectable		 6gtqB-5tgdA:
19.70
6gtqD-5tgdA:
10.71