SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tgt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 405
LEU A 467
SER A 463
LEU A 452
ILE A 420
 None
 1.40A 1fmlA-5tgtA:
undetectable		 1fmlA-5tgtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 GLN A 469
TYR A 465
PHE A 263
PRO A 258
 None
 1.23A 3tgvB-5tgtA:
undetectable		 3tgvB-5tgtA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 GLN A 469
TYR A 465
PHE A 263
PRO A 258
 None
 1.21A 3tgvD-5tgtA:
undetectable		 3tgvD-5tgtA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 467
LEU A 405
ILE A 492
ILE A 488
GLN A 399
 None
 1.44A 3tmzA-5tgtA:
undetectable		 3tmzA-5tgtA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  36
THR A   3
MET A 206
GLY A 207
 None
 0.86A 4fo4B-5tgtA:
undetectable		 4fo4B-5tgtA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 466
GLY A 375
PHE A 373
ALA A 342
TRP A 341
 None
None
None
SO4  A 607 (-4.4A)
None
 1.12A 4ryaA-5tgtA:
undetectable		 4ryaA-5tgtA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 337
TRP A 341
ASN A 322
 None
 1.14A 5dv4A-5tgtA:
undetectable		 5dv4A-5tgtA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A  83
GLU A  86
GLY A  80
PRO A  81
 None
 1.15A 5kf8A-5tgtA:
undetectable		 5kf8A-5tgtA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A  86
PRO A  73
GLY A  80
PRO A  81
 None
 1.09A 5kf8A-5tgtA:
undetectable		 5kf8A-5tgtA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  77
ILE A  39
ASP A  70
ASP A  74
 None
 1.00A 5vlmH-5tgtA:
undetectable		 5vlmH-5tgtA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 467
ILE A 416
MET A 438
LEU A 389
LEU A 427
 None
 1.46A 5ycpA-5tgtA:
undetectable		 5ycpA-5tgtA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5tgt GLUTAMATE--TRNA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 TRP A 341
GLY A 370
ARG A 466
LEU A 462
 None
 1.00A 6btxA-5tgtA:
undetectable		 6btxA-5tgtA:
21.00