SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5th3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 5th3 R-SWAI PROTEIN
(Staphylococcus
warneri) 		3 / 3 VAL A 126
TRP A  91
TRP A  75
 None
 1.45A 1c4dA-5th3A:
undetectable
1c4dB-5th3A:
undetectable		 1c4dA-5th3A:
5.52
1c4dB-5th3A:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5th3 R-SWAI PROTEIN
(Staphylococcus
warneri) 		5 / 10 ILE A 108
ASN A 105
LEU A 129
TYR A 144
ALA A 174
 None
 1.43A 1ju6C-5th3A:
undetectable		 1ju6C-5th3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5th3 R-SWAI PROTEIN
(Staphylococcus
warneri) 		5 / 11 ILE A 108
ASN A 105
LEU A 129
TYR A 144
ALA A 174
 None
 1.43A 1ju6D-5th3A:
undetectable		 1ju6D-5th3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 5th3 R-SWAI PROTEIN
(Staphylococcus
warneri) 		5 / 12 GLU A   7
LEU A 153
ILE A 118
GLU A  88
ARG A  86
 None
 1.41A 1l7fA-5th3A:
undetectable		 1l7fA-5th3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5th3 R-SWAI PROTEIN
(Staphylococcus
warneri) 		5 / 12 PHE A  81
ILE A  90
ILE A  92
CYH A  79
PHE A  48
 None
 1.22A 2ft9A-5th3A:
undetectable		 2ft9A-5th3A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 5th3 R-SWAI PROTEIN
(Staphylococcus
warneri) 		4 / 5 PHE A 127
ILE A  18
ASN A 158
PHE A  94
 None
 0.93A 3octA-5th3A:
undetectable		 3octA-5th3A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5th3 R-SWAI PROTEIN
(Staphylococcus
warneri) 		4 / 7 TYR A   6
GLU A  87
GLU A  88
GLU A  89
 None
 1.28A 4mi4A-5th3A:
undetectable
4mi4C-5th3A:
undetectable		 4mi4A-5th3A:
21.25
4mi4C-5th3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 5th3 R-SWAI PROTEIN
(Staphylococcus
warneri) 		5 / 12 GLU A   7
LEU A 153
ILE A 118
GLU A  88
ARG A  86
 None
 1.43A 4mwvA-5th3A:
undetectable		 4mwvA-5th3A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 5th3 R-SWAI PROTEIN
(Staphylococcus
warneri) 		5 / 12 GLY A  37
ALA A  96
VAL A 130
LEU A  44
ILE A  30
 None
 1.03A 4pd9A-5th3A:
undetectable		 4pd9A-5th3A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5th3 R-SWAI PROTEIN
(Staphylococcus
warneri) 		5 / 11 ILE A 108
ASN A 105
LEU A 129
TYR A 144
ALA A 174
 None
 1.38A 5fctA-5th3A:
undetectable		 5fctA-5th3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5th3 R-SWAI PROTEIN
(Staphylococcus
warneri) 		4 / 4 ASN A 122
ILE A  52
TYR A  61
PHE A  83
 None
 1.21A 5igvA-5th3A:
undetectable		 5igvA-5th3A:
21.52