SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5th6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 11 ILE A 166
ALA A 191
PHE A 403
LEU A 395
ILE A 168
 None
 1.03A 1dg5A-5th6A:
undetectable		 1dg5A-5th6A:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.19A 1os2A-5th6A:
24.2		 1os2A-5th6A:
36.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.19A 1os2D-5th6A:
24.3		 1os2D-5th6A:
36.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.24A 1uttA-5th6A:
24.8		 1uttA-5th6A:
40.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.18A 1utzA-5th6A:
24.7		 1utzA-5th6A:
40.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.22A 1utzB-5th6A:
24.8		 1utzB-5th6A:
40.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 6 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.21A 1y93A-5th6A:
25.0		 1y93A-5th6A:
35.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 7 GLY A 100
TYR A  52
GLU A 402
HIS A 401
 None
None
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.3A)
 1.06A 2ackA-5th6A:
undetectable		 2ackA-5th6A:
17.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.19A 2hu6A-5th6A:
25.1		 2hu6A-5th6A:
35.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		6 / 9 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
MET A 422
 None
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
None
 0.49A 2jihA-5th6A:
9.2		 2jihA-5th6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 8 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 None
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.34A 2jihB-5th6A:
9.3		 2jihB-5th6A:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		6 / 6 LEU A 187
HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 None
ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.52A 2ow9A-5th6A:
24.2		 2ow9A-5th6A:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.17A 2ow9B-5th6A:
24.1		 2ow9B-5th6A:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.12A 2ozrC-5th6A:
23.9		 2ozrC-5th6A:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.13A 2ozrD-5th6A:
24.1		 2ozrD-5th6A:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.26A 2ozrE-5th6A:
24.0		 2ozrE-5th6A:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 401
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.22A 2ozrF-5th6A:
23.7		 2ozrF-5th6A:
43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 7 ILE A 166
LEU A 407
GLY A 404
PHE A 403
 None
 0.88A 2tsrA-5th6A:
undetectable		 2tsrA-5th6A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 190
GLU A 402
HIS A 405
 ZN  A 502 (-3.2A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
 0.49A 3ba0A-5th6A:
22.1		 3ba0A-5th6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 12 GLY A 215
SER A 394
LEU A 188
LEU A 132
LEU A 212
 None
 1.31A 3cs8A-5th6A:
undetectable		 3cs8A-5th6A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 7 GLY A 195
HIS A 118
ASP A 165
ILE A 166
 None
 0.89A 3fi0P-5th6A:
undetectable		 3fi0P-5th6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 9 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 None
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.36A 3hy7A-5th6A:
9.4		 3hy7A-5th6A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 9 LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 None
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.31A 3hy7B-5th6A:
9.4		 3hy7B-5th6A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.15A 3kecA-5th6A:
24.1		 3kecA-5th6A:
44.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 HIS A 401
GLU A 402
HIS A 405
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
 0.15A 3kecB-5th6A:
23.9		 3kecB-5th6A:
44.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.29A 3likA-5th6A:
25.0		 3likA-5th6A:
35.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.21A 3lilA-5th6A:
25.0		 3lilA-5th6A:
35.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.23A 3ljgA-5th6A:
24.8		 3ljgA-5th6A:
35.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.29A 3lkaA-5th6A:
25.0		 3lkaA-5th6A:
40.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 PHE A 204
PHE A 403
ALA A 400
LEU A 395
 None
 1.13A 3t3zC-5th6A:
undetectable		 3t3zC-5th6A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 GLN A 108
PHE A 192
TYR A 179
 None
 0.93A 3ucjB-5th6A:
undetectable		 3ucjB-5th6A:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 6 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.30A 4a7bA-5th6A:
24.1		 4a7bA-5th6A:
44.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 5 LEU A 187
HIS A 190
HIS A 401
GLU A 402
HIS A 405
 None
ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
 0.61A 4a7bB-5th6A:
24.0		 4a7bB-5th6A:
44.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 ASP A 434
LYS A 433
ASP A 435
 None
 0.82A 4a7tA-5th6A:
undetectable		 4a7tA-5th6A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 10 ILE A 166
ALA A 191
PHE A 403
LEU A 395
ILE A 168
 None
 1.05A 4km0A-5th6A:
undetectable		 4km0A-5th6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 12 ILE A 166
ALA A 191
PHE A 403
LEU A 395
ILE A 168
 None
 1.06A 4km0B-5th6A:
undetectable		 4km0B-5th6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 6 ARG A 106
GLY A 112
ASP A 113
GLY A 195
 None
 0.88A 4koeA-5th6A:
undetectable
4koeB-5th6A:
undetectable
4koeC-5th6A:
undetectable		 4koeA-5th6A:
18.15
4koeB-5th6A:
18.15
4koeC-5th6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 7 ARG A 106
GLY A 112
ASP A 113
GLY A 195
 None
 0.90A 4koeA-5th6A:
undetectable
4koeB-5th6A:
undetectable
4koeD-5th6A:
undetectable		 4koeA-5th6A:
18.15
4koeB-5th6A:
18.15
4koeD-5th6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		5 / 12 ILE A 166
ALA A 191
PHE A 403
LEU A 395
ILE A 168
 None
 0.95A 4m2xA-5th6A:
undetectable		 4m2xA-5th6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 6 GLY A 112
ASP A 113
GLY A 195
ARG A 106
 None
 0.75A 4z53A-5th6A:
1.7
4z53B-5th6A:
undetectable		 4z53A-5th6A:
16.17
4z53B-5th6A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 7 ARG A 106
GLY A 112
ASP A 113
GLY A 195
 None
 0.92A 4z53A-5th6A:
undetectable
4z53B-5th6A:
undetectable		 4z53A-5th6A:
16.17
4z53B-5th6A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 TYR A  48
GLY A 100
TYR A  54
GLY A 105
 None
 1.07A 5ayfA-5th6A:
undetectable		 5ayfA-5th6A:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.21A 5n5jA-5th6A:
25.2		 5n5jA-5th6A:
40.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.17A 5n5kA-5th6A:
25.0		 5n5kA-5th6A:
37.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 4 HIS A 401
CYH A  99
HIS A 411
HIS A 405
 ZN  A 501 (-3.3A)
ZN  A 501 (-2.2A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 1.43A 5zrdA-5th6A:
undetectable		 5zrdA-5th6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 190
HIS A 175
HIS A 203
PHE A 192
 ZN  A 502 (-3.2A)
ZN  A 502 (-3.2A)
ZN  A 502 (-3.1A)
None
 1.22A 5zrdB-5th6A:
undetectable		 5zrdB-5th6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 190
HIS A 175
HIS A 203
PHE A 192
 ZN  A 502 (-3.2A)
ZN  A 502 (-3.2A)
ZN  A 502 (-3.1A)
None
 1.17A 5zrdC-5th6A:
undetectable		 5zrdC-5th6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		4 / 5 HIS A 190
HIS A 175
HIS A 203
PHE A 192
 ZN  A 502 (-3.2A)
ZN  A 502 (-3.2A)
ZN  A 502 (-3.1A)
None
 1.20A 5zrdD-5th6A:
undetectable		 5zrdD-5th6A:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens) 		3 / 3 TYR A 179
HIS A 190
PHE A 192
 None
ZN  A 502 (-3.2A)
None
 0.35A 6esmA-5th6A:
26.6		 6esmA-5th6A:
100.00