SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5thg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5thg I-ONUI_E-HCCR5
(synthetic
construct) 		5 / 11 ILE A 216
LEU A 171
ILE A 202
PHE A 237
ILE A 249
 None
 1.08A 1dyrA-5thgA:
undetectable		 1dyrA-5thgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5thg I-ONUI_E-HCCR5
(synthetic
construct) 		5 / 12 LEU A 258
THR A 175
LEU A 168
LEU A 171
PHE A 181
 None
 1.39A 3glqA-5thgA:
undetectable		 3glqA-5thgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5thg I-ONUI_E-HCCR5
(synthetic
construct) 		3 / 3 LEU A  99
TRP A 170
GLY A 173
 None
 0.80A 3l35A-5thgA:
undetectable
3l35H-5thgA:
undetectable		 3l35A-5thgA:
10.38
3l35H-5thgA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5thg I-ONUI_E-HCCR5
(synthetic
construct) 		3 / 3 LEU A  99
TRP A 170
GLY A 173
 None
 0.77A 3l35B-5thgA:
undetectable
3l35K-5thgA:
undetectable		 3l35B-5thgA:
10.38
3l35K-5thgA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5thg I-ONUI_E-HCCR5
(synthetic
construct) 		5 / 12 LEU A 258
THR A 175
LEU A 168
LEU A 171
PHE A 181
 None
 1.36A 3n58A-5thgA:
undetectable		 3n58A-5thgA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5thg I-ONUI_E-HCCR5
(synthetic
construct) 		3 / 3 TYR A  39
THR A  41
THR A  32
 None
 0.82A 5aoxB-5thgA:
undetectable		 5aoxB-5thgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5thg I-ONUI_E-HCCR5
(synthetic
construct) 		4 / 8 ILE A  14
GLY A 177
LEU A  49
LEU A  57
 None
CA  A 401 (-4.2A)
None
None
 0.76A 5hs1A-5thgA:
undetectable		 5hs1A-5thgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 5thg I-ONUI_E-HCCR5
(synthetic
construct) 		4 / 8 TRP A  64
LEU A  99
TYR A 107
THR A  19
 None
 1.02A 6c71B-5thgA:
undetectable		 6c71B-5thgA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5thg I-ONUI_E-HCCR5
(synthetic
construct) 		4 / 6 PHE A 150
LEU A 146
ALA A 149
THR A  32
 None
 0.87A 6f88A-5thgA:
undetectable		 6f88A-5thgA:
13.59