SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5thh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 LEU A  76
HIS A  77
LEU A 165
LEU A 169
 None
TYR  A 401 (-3.5A)
None
None
 0.95A 1e7cA-5thhA:
undetectable		 1e7cA-5thhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 TYR A  96
PHE A 328
ASP A 233
LEU A 234
 None
 1.06A 1e7cA-5thhA:
undetectable		 1e7cA-5thhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ILE A 101
ILE A  71
PHE A 117
VAL A 110
LEU A  63
 None
 0.95A 1qhsA-5thhA:
undetectable		 1qhsA-5thhA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 LEU A 177
TRP A  40
ILE A 118
TYR A 123
 None
 1.05A 1qvtA-5thhA:
undetectable		 1qvtA-5thhA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ALA A  65
LEU A  13
ALA A  60
VAL A 208
LEU A  31
 None
 0.98A 1xiuB-5thhA:
undetectable		 1xiuB-5thhA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 9 GLY A 168
ALA A 171
LEU A 172
TYR A 123
HIS A  77
 None
None
None
None
TYR  A 401 (-3.5A)
 1.13A 1y7iA-5thhA:
undetectable		 1y7iA-5thhA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 TYR A  52
TRP A  40
TYR A  97
ILE A  71
 None
 1.33A 2xz5B-5thhA:
undetectable
2xz5E-5thhA:
undetectable		 2xz5B-5thhA:
21.45
2xz5E-5thhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ILE A  71
TYR A  52
TRP A  40
TYR A  97
 None
 1.36A 2xz5D-5thhA:
undetectable
2xz5E-5thhA:
undetectable		 2xz5D-5thhA:
21.45
2xz5E-5thhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ILE A  71
TYR A  52
TRP A  40
TYR A  97
 None
 1.36A 2xz5D-5thhA:
undetectable
2xz5E-5thhA:
undetectable		 2xz5D-5thhA:
21.45
2xz5E-5thhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 GLY A  41
HIS A  77
ASP A 173
GLN A 188
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.4A)
TYR  A 401 (-3.0A)
 0.83A 3fi0P-5thhA:
16.9		 3fi0P-5thhA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 PHE A  73
TYR A  96
LEU A  76
 None
 0.71A 3keeB-5thhA:
undetectable		 3keeB-5thhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 THR A  45
TYR A  97
HIS A  49
TYR A  52
 None
 1.19A 4df2A-5thhA:
undetectable		 4df2A-5thhA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 TYR A 289
ARG A 279
LYS A 287
 None
 1.33A 4wq5B-5thhA:
1.5		 4wq5B-5thhA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ILE A 232
LEU A 268
ILE A 264
LEU A 234
 None
 0.72A 5ieoA-5thhA:
undetectable		 5ieoA-5thhA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 PRO A  86
ARG A  93
GLU A  88
 None
 0.91A 5j6hA-5thhA:
undetectable		 5j6hA-5thhA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 GLY A 149
GLN A 124
TYR A 129
ASP A 187
 None
 1.07A 5vlmE-5thhA:
undetectable		 5vlmE-5thhA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ALA A  65
LEU A  13
ALA A  60
VAL A 208
LEU A  31
 None
 0.98A 5z12B-5thhA:
undetectable		 5z12B-5thhA:
13.65