SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5thk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 ALA A  75
LYS A  78
ASP A  82
ALA A  83
 None
 0.29A 1iwhA-5thkA:
undetectable		 1iwhA-5thkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 ASN A 120
ALA A 124
ASN A  95
 None
 0.75A 1n4fA-5thkA:
undetectable		 1n4fA-5thkA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		6 / 12 ILE A 250
GLY A 188
GLY A 150
VAL A 229
VAL A 187
ALA A 186
 None
 1.22A 1vptA-5thkA:
5.4		 1vptA-5thkA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ARG A 180
ALA A 131
ILE A 128
PHE A 125
GLU A 136
 None
 1.38A 3qelA-5thkA:
4.4
3qelB-5thkA:
3.3		 3qelA-5thkA:
22.11
3qelB-5thkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 VAL A 206
ALA A 205
ALA A 151
LEU A 223
TYR A 254
 None
 1.18A 3qxyA-5thkA:
undetectable		 3qxyA-5thkA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 GLN A  67
LEU A  70
THR A  71
THR A  72
VAL A  97
 None
NAP  A 300 (-4.1A)
NAP  A 300 (-3.8A)
None
NAP  A 300 (-3.4A)
 0.94A 4e3hA-5thkA:
undetectable		 4e3hA-5thkA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 4 LYS A  78
ALA A  75
SER A 123
THR A  72
 None
 1.48A 4i89B-5thkA:
undetectable		 4i89B-5thkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 PHE A 127
SER A 123
ALA A  68
LEU A  79
ALA A  61
 None
 1.06A 4l6v1-5thkA:
undetectable
4l6v6-5thkA:
undetectable		 4l6v1-5thkA:
15.88
4l6v6-5thkA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 9 PHE A 127
SER A 123
ALA A  68
LEU A  79
ALA A  61
 None
 1.06A 4l6va-5thkA:
undetectable
4l6vf-5thkA:
undetectable		 4l6va-5thkA:
15.88
4l6vf-5thkA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 ARG A 180
ALA A 131
ILE A 128
PHE A 125
GLU A 136
 None
 1.40A 4pe5A-5thkA:
6.3
4pe5B-5thkA:
2.7		 4pe5A-5thkA:
16.19
4pe5B-5thkA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 ARG A 180
ALA A 131
ILE A 128
PHE A 125
GLU A 136
 None
 1.39A 4pe5C-5thkA:
6.3
4pe5D-5thkA:
4.5		 4pe5C-5thkA:
16.19
4pe5D-5thkA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 PHE A 127
SER A 123
ALA A  68
LEU A  79
 None
 1.10A 4xk8A-5thkA:
undetectable		 4xk8A-5thkA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ARG A 180
ALA A 131
ILE A 128
PHE A 125
GLU A 136
 None
 1.37A 5ewjA-5thkA:
6.5
5ewjB-5thkA:
2.9		 5ewjA-5thkA:
21.30
5ewjB-5thkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ARG A 180
ALA A 131
ILE A 128
PHE A 125
GLU A 136
 None
 1.39A 5ewjC-5thkA:
6.1
5ewjD-5thkA:
5.1		 5ewjC-5thkA:
21.30
5ewjD-5thkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ILE A  92
LEU A   6
ALA A   7
VAL A 142
LEU A 135
 None
 1.23A 5ji0A-5thkA:
undetectable		 5ji0A-5thkA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 GLU A 201
TYR A 156
TYR A 208
PHE A 197
 None
 1.28A 5lrbA-5thkA:
4.2		 5lrbA-5thkA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 5thk PUTATIVE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 GLN A  67
LEU A  70
THR A  71
THR A  72
 None
NAP  A 300 (-4.1A)
NAP  A 300 (-3.8A)
None
 0.89A 5m78A-5thkA:
undetectable		 5m78A-5thkA:
13.50