SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5thm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		6 / 12 GLY A 108
GLY A 109
SER A 188
TRP A 221
PHE A 276
HIS A 445
 7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
None
7BZ  A 601 ( 4.9A)
7BZ  A 601 (-3.8A)
 0.98A 1dx6A-5thmA:
40.4		 1dx6A-5thmA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 GLY A 190
GLY A 108
GLY A 109
PHE A 113
HIS A 445
 None
7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.8A)
 0.98A 1dx6A-5thmA:
40.4		 1dx6A-5thmA:
31.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.38A 1fohA-5thmA:
undetectable		 1fohA-5thmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.36A 1fohC-5thmA:
undetectable		 1fohC-5thmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.38A 1fohD-5thmA:
undetectable		 1fohD-5thmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 THR A  86
VAL A  87
SER A  88
GLY A 109
ALA A 115
 None
None
None
7BZ  A 601 (-3.0A)
None
 1.09A 1jg4A-5thmA:
undetectable		 1jg4A-5thmA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 6 SER A 314
ASN A 216
LEU A 218
ASP A 219
 None
 1.29A 1mxdA-5thmA:
undetectable		 1mxdA-5thmA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.36A 1pn0C-5thmA:
undetectable		 1pn0C-5thmA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.36A 1pn0D-5thmA:
undetectable		 1pn0D-5thmA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 7 ILE A 223
LEU A 184
ILE A 135
ILE A 168
 None
None
None
MLY  A 169 ( 3.7A)
 0.81A 1uwjA-5thmA:
undetectable		 1uwjA-5thmA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 11 GLY A 108
GLY A 109
SER A 188
PHE A 113
HIS A 445
 7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.8A)
 0.95A 1w76A-5thmA:
39.5		 1w76A-5thmA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 GLY A 108
GLY A 109
SER A 188
PHE A 276
HIS A 445
 7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
7BZ  A 601 ( 4.9A)
7BZ  A 601 (-3.8A)
 1.09A 1w76B-5thmA:
39.6		 1w76B-5thmA:
31.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 GLY A 186
GLY A 190
GLY A 108
PHE A 473
SER A 212
 None
None
7BZ  A 601 ( 3.6A)
None
None
 1.13A 1wg8A-5thmA:
undetectable		 1wg8A-5thmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 GLY A 186
GLY A 190
GLY A 108
PHE A 473
SER A 212
 None
None
7BZ  A 601 ( 3.6A)
None
None
 1.20A 1wg8B-5thmA:
undetectable		 1wg8B-5thmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 9 GLY A 109
ALA A 110
SER A 188
PHE A 276
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-2.9A)
7BZ  A 601 (-1.4A)
7BZ  A 601 ( 4.9A)
7BZ  A 601 (-3.8A)
 1.03A 1y7iA-5thmA:
9.9		 1y7iA-5thmA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		6 / 9 GLY A 108
GLY A 109
SER A 188
ALA A 189
PHE A 113
HIS A 445
 7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.8A)
 0.96A 2aceA-5thmA:
9.5		 2aceA-5thmA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 9 GLY A 109
SER A 188
ALA A 189
TRP A 221
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
7BZ  A 601 (-3.7A)
None
7BZ  A 601 (-3.8A)
 0.40A 2aceA-5thmA:
9.5		 2aceA-5thmA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 8 VAL A 432
VAL A 457
LEU A 433
HIS A 445
 None
None
None
7BZ  A 601 (-3.8A)
 1.08A 2ddwA-5thmA:
undetectable		 2ddwA-5thmA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 7 GLY A 108
GLY A 109
ALA A 189
PHE A 113
HIS A 445
 7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.7A)
7BZ  A 601 (-3.8A)
 0.97A 2ha4B-5thmA:
39.4		 2ha4B-5thmA:
30.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 7 GLY A 109
ALA A 189
TRP A 221
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-3.7A)
None
7BZ  A 601 (-3.8A)
 0.28A 2ha4B-5thmA:
39.4		 2ha4B-5thmA:
30.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 7 PHE A 397
PHE A 111
ILE A 293
GLY A 215
 None
 0.98A 2v0mB-5thmA:
undetectable		 2v0mB-5thmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 ALA A 418
VAL A 313
GLN A 308
PHE A 306
LYS A 414
 None
None
MLY  A 413 ( 3.5A)
None
MLY  A 413 ( 3.1A)
 1.27A 2v95A-5thmA:
undetectable		 2v95A-5thmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 7 PHE A 279
ALA A 264
LEU A 261
PHE A  42
 None
None
MLY  A 256 ( 4.9A)
None
 0.92A 2vcvA-5thmA:
undetectable		 2vcvA-5thmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 7 PHE A 279
ALA A 264
LEU A 261
PHE A  42
 None
None
MLY  A 256 ( 4.9A)
None
 0.91A 2vcvG-5thmA:
undetectable		 2vcvG-5thmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 7 PHE A 279
ALA A 264
LEU A 261
PHE A  42
 None
None
MLY  A 256 ( 4.9A)
None
 0.93A 2vcvL-5thmA:
undetectable		 2vcvL-5thmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 8 HIS A 445
ASP A 319
SER A 214
HIS A 187
 7BZ  A 601 (-3.8A)
None
None
7BZ  A 601 ( 4.8A)
 1.12A 2xadD-5thmA:
undetectable		 2xadD-5thmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		3 / 3 LEU A 433
TRP A 221
TYR A 273
 None
 1.00A 3aicA-5thmA:
undetectable		 3aicA-5thmA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		3 / 3 LEU A 433
TRP A 221
TYR A 273
 None
 0.98A 3aicF-5thmA:
undetectable		 3aicF-5thmA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 7 ARG A 228
ASP A 149
ASP A 151
PHE A 232
 None
None
MLY  A 250 ( 4.4A)
None
 0.95A 3kivA-5thmA:
undetectable		 3kivA-5thmA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 7 GLY A 109
SER A 188
TRP A 221
PHE A 397
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
None
None
7BZ  A 601 (-3.8A)
 0.50A 3o9mA-5thmA:
40.4		 3o9mA-5thmA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 6 GLY A 109
SER A 188
TRP A 221
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
None
7BZ  A 601 (-3.8A)
 0.36A 3o9mB-5thmA:
40.4		 3o9mB-5thmA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 ALA A 231
GLY A 235
SER A 237
LEU A 249
ALA A 227
 None
None
MLY  A 267 ( 3.8A)
MLY  A 250 ( 3.7A)
None
 1.14A 3ou6C-5thmA:
undetectable		 3ou6C-5thmA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 ALA A 231
GLY A 235
SER A 237
LEU A 249
ALA A 227
 None
None
MLY  A 267 ( 3.8A)
MLY  A 250 ( 3.7A)
None
 1.14A 3ou7C-5thmA:
undetectable		 3ou7C-5thmA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 10 PRO A  62
ASN A 119
HIS A 105
GLY A 114
ALA A 115
 MLY  A  60 ( 4.3A)
None
None
None
None
 1.49A 3pp7B-5thmA:
undetectable		 3pp7B-5thmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 11 SER A 174
ILE A 172
VAL A  89
VAL A 133
ILE A  30
 None
 1.38A 3rf4A-5thmA:
1.2
3rf4C-5thmA:
1.1		 3rf4A-5thmA:
12.76
3rf4C-5thmA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 6 HIS A 187
SER A 214
GLU A 318
ASP A 448
 7BZ  A 601 ( 4.8A)
None
None
None
 1.40A 4blvA-5thmA:
undetectable		 4blvA-5thmA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 5 ARG A 343
VAL A 274
LEU A 269
SER A 272
 None
 1.18A 4e1gA-5thmA:
undetectable		 4e1gA-5thmA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		3 / 3 SER A  26
TYR A  24
PRO A  62
 None
None
MLY  A  60 ( 4.3A)
 0.81A 4k8cA-5thmA:
undetectable		 4k8cA-5thmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		3 / 3 SER A  26
TYR A  24
PRO A  62
 None
None
MLY  A  60 ( 4.3A)
 0.79A 4kahA-5thmA:
undetectable		 4kahA-5thmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		3 / 3 SER A  26
TYR A  24
PRO A  62
 None
None
MLY  A  60 ( 4.3A)
 0.79A 4kahB-5thmA:
undetectable		 4kahB-5thmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		3 / 3 SER A  26
TYR A  24
PRO A  62
 None
None
MLY  A  60 ( 4.3A)
 0.82A 4kanA-5thmA:
undetectable		 4kanA-5thmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		3 / 3 SER A  26
TYR A  24
PRO A  62
 None
None
MLY  A  60 ( 4.3A)
 0.78A 4kbeA-5thmA:
undetectable		 4kbeA-5thmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		3 / 3 SER A  26
TYR A  24
PRO A  62
 None
None
MLY  A  60 ( 4.3A)
 0.83A 4lbgA-5thmA:
undetectable		 4lbgA-5thmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		3 / 3 SER A  26
TYR A  24
PRO A  62
 None
None
MLY  A  60 ( 4.3A)
 0.82A 4lbgB-5thmA:
undetectable		 4lbgB-5thmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 9 ALA A 115
ALA A  64
GLY A 108
GLY A 109
ASP A  69
 None
None
7BZ  A 601 ( 3.6A)
7BZ  A 601 (-3.0A)
None
 1.06A 4qwuY-5thmA:
undetectable
4qwuZ-5thmA:
undetectable		 4qwuY-5thmA:
18.41
4qwuZ-5thmA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 5 PHE A 111
PRO A 278
ALA A 110
PHE A 353
 None
None
7BZ  A 601 (-2.9A)
None
 1.23A 4w5oA-5thmA:
undetectable		 4w5oA-5thmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 5 PHE A 111
PRO A 278
ALA A 110
PHE A 353
 None
None
7BZ  A 601 (-2.9A)
None
 1.25A 4z4cA-5thmA:
undetectable		 4z4cA-5thmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 5 PHE A 111
PRO A 278
ALA A 110
PHE A 353
 None
None
7BZ  A 601 (-2.9A)
None
 1.25A 4z4dA-5thmA:
undetectable		 4z4dA-5thmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 5 PHE A 111
PRO A 278
ALA A 110
PHE A 353
 None
None
7BZ  A 601 (-2.9A)
None
 1.23A 4z4eA-5thmA:
3.1		 4z4eA-5thmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 4 LEU A 132
MET A 125
VAL A 124
ASN A 123
 None
MLY  A  91 ( 3.9A)
None
None
 1.15A 5b8iB-5thmA:
undetectable		 5b8iB-5thmA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 6 PRO A 220
HIS A 445
LEU A 327
TYR A 273
 None
7BZ  A 601 (-3.8A)
None
None
 1.10A 5igiA-5thmA:
undetectable		 5igiA-5thmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 5 PRO A 220
HIS A 445
LEU A 327
TYR A 273
 None
7BZ  A 601 (-3.8A)
None
None
 1.10A 5igjA-5thmA:
undetectable		 5igjA-5thmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		5 / 12 VAL A 282
LEU A 249
ASP A 149
ALA A 227
GLY A 143
 None
MLY  A 250 ( 3.7A)
None
None
None
 1.19A 5syeB-5thmA:
2.8		 5syeB-5thmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 6 TYR A 137
PRO A 141
LEU A 145
PHE A 144
 None
 1.06A 5tl8A-5thmA:
undetectable		 5tl8A-5thmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5thm ESTERASE-6
(Drosophila
melanogaster) 		4 / 8 ARG A 162
ARG A 200
ILE A 223
PRO A 281
 MLY  A 166 ( 4.0A)
None
None
None
 0.90A 6a4iA-5thmA:
undetectable		 6a4iA-5thmA:
22.86