SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5thw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 5 ARG A 301
ASP A 372
SER A  95
ASN A  76
 URP  A 503 (-2.9A)
None
ZN  A 501 ( 4.9A)
None
 1.24A 1kiaB-5thwA:
undetectable		 1kiaB-5thwA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5thw DEACYLASE
(Burkholderia
multivorans) 		5 / 9 TYR A 229
ASP A 312
LEU A 332
VAL A 258
PHE A 300
 None
 1.22A 1q6iA-5thwA:
undetectable		 1q6iA-5thwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 7 ILE A 231
TYR A 229
PHE A 300
ASP A 312
 None
 1.12A 2qebA-5thwA:
undetectable		 2qebA-5thwA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 7 ILE A 231
TYR A 229
PHE A 300
ASP A 312
 None
 1.12A 2qebB-5thwA:
undetectable		 2qebB-5thwA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 8 ILE A 137
SER A 153
ASP A  98
SER A  95
 None
None
None
ZN  A 501 ( 4.9A)
 1.12A 2zw9B-5thwA:
undetectable		 2zw9B-5thwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 5thw DEACYLASE
(Burkholderia
multivorans) 		5 / 10 TYR A 229
ASP A 312
LEU A 332
VAL A 258
PHE A 300
 None
 1.35A 3kz7A-5thwA:
undetectable		 3kz7A-5thwA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		3 / 3 TYR A 229
ASP A 305
ASP A 312
 None
 0.76A 3r24A-5thwA:
undetectable		 3r24A-5thwA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		3 / 3 GLU A 205
PHE A 386
GLN A 206
 None
None
URP  A 503 (-3.1A)
 1.02A 3r55A-5thwA:
undetectable		 3r55A-5thwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 8 ALA A 369
GLY A 370
GLN A 226
GLU A 141
 URP  A 503 (-3.2A)
URP  A 503 (-3.5A)
URP  A 503 (-3.4A)
URP  A 503 ( 2.9A)
 0.95A 3rglA-5thwA:
undetectable		 3rglA-5thwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		3 / 3 GLY A 154
SER A 153
TRP A 138
 None
 0.97A 4e7cD-5thwA:
undetectable		 4e7cD-5thwA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 8 THR A 129
THR A  93
LEU A 122
VAL A 118
 None
 0.97A 4l4eA-5thwA:
undetectable		 4l4eA-5thwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 8 THR A 129
THR A  93
LEU A 122
VAL A 118
 None
 0.97A 4l4fA-5thwA:
undetectable		 4l4fA-5thwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 5 ARG A  55
ASP A  98
GLU A 179
VAL A 171
 None
 1.31A 4nkvB-5thwA:
undetectable		 4nkvB-5thwA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 5 ARG A  55
ASP A  98
GLU A 179
VAL A 171
 None
 1.22A 4nkxD-5thwA:
undetectable		 4nkxD-5thwA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		5 / 11 GLY A 111
GLY A 114
VAL A 135
ASP A 372
ILE A 109
 None
 1.15A 4pghA-5thwA:
undetectable		 4pghA-5thwA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		5 / 11 HIS A  96
ASP A 107
GLU A 141
GLU A 142
HIS A 395
 ZN  A 501 ( 3.5A)
ZN  A 502 (-2.4A)
URP  A 503 ( 2.9A)
ZN  A 502 ( 2.1A)
ZN  A 502 ( 3.3A)
 0.39A 4pqaA-5thwA:
28.2		 4pqaA-5thwA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		5 / 11 HIS A  96
ASP A 107
GLU A 142
GLY A 368
HIS A 395
 ZN  A 501 ( 3.5A)
ZN  A 502 (-2.4A)
ZN  A 502 ( 2.1A)
None
ZN  A 502 ( 3.3A)
 0.64A 4pqaA-5thwA:
28.2		 4pqaA-5thwA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 5 TYR A 360
TRP A 405
LEU A 202
LEU A 414
 None
 1.43A 5eshA-5thwA:
undetectable		 5eshA-5thwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		5 / 12 ALA A 416
VAL A 351
GLY A 409
GLU A 117
ALA A 408
 None
 1.15A 5n5dA-5thwA:
undetectable		 5n5dA-5thwA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5thw DEACYLASE
(Burkholderia
multivorans) 		5 / 12 ALA A  53
GLY A  54
ASN A  26
LEU A 113
GLU A 117
 None
 1.18A 5nwuA-5thwA:
undetectable		 5nwuA-5thwA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 4 THR A  48
ASP A  51
ARG A  44
LEU A  45
 None
 1.38A 5tdmA-5thwA:
1.3		 5tdmA-5thwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5thw DEACYLASE
(Burkholderia
multivorans) 		3 / 3 GLU A 163
TYR A 164
ARG A 168
 None
 0.68A 5uunA-5thwA:
undetectable		 5uunA-5thwA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5thw DEACYLASE
(Burkholderia
multivorans) 		3 / 3 GLU A 163
TYR A 164
ARG A 168
 None
 0.69A 5uunB-5thwA:
undetectable		 5uunB-5thwA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5thw DEACYLASE
(Burkholderia
multivorans) 		4 / 4 ARG A 301
SER A 394
ASP A 107
HIS A  96
 URP  A 503 (-2.9A)
None
ZN  A 502 (-2.4A)
ZN  A 501 ( 3.5A)
 1.45A 5zhmA-5thwA:
1.6		 5zhmA-5thwA:
21.79