SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5thx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A  35
LEU A 112
GLN A 134
LEU A 104
CYH A 102
 None
 0.94A 1p93C-5thxA:
undetectable		 1p93C-5thxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 5 ALA A  58
ASN A  34
ILE A 125
ASP A 128
 None
 1.08A 2h4jA-5thxA:
3.7		 2h4jA-5thxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 10 LEU A 225
ARG A 190
PRO A 121
SER A  54
GLY A 116
 None
NAP  A 301 (-3.3A)
None
FAD  A 303 (-3.8A)
NAP  A 301 ( 3.9A)
 1.30A 2qd4B-5thxA:
2.5		 2qd4B-5thxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 8 LEU A 225
PRO A 121
SER A  54
GLY A 116
 None
None
FAD  A 303 (-3.8A)
NAP  A 301 ( 3.9A)
 1.11A 2qd5A-5thxA:
2.4		 2qd5A-5thxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		3 / 3 THR A  21
SER A  57
LYS A 127
 None
 0.88A 3aocC-5thxA:
undetectable		 3aocC-5thxA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_A_CHDA2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 9 LEU A 225
ARG A 190
PRO A 121
SER A  54
GLY A 116
 None
NAP  A 301 (-3.3A)
None
FAD  A 303 (-3.8A)
NAP  A 301 ( 3.9A)
 1.16A 3hcpA-5thxA:
2.6		 3hcpA-5thxA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 7 LEU A 225
ARG A 190
PRO A 121
SER A  54
GLY A 116
 None
NAP  A 301 (-3.3A)
None
FAD  A 303 (-3.8A)
NAP  A 301 ( 3.9A)
 1.45A 3hcrB-5thxA:
2.5		 3hcrB-5thxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		3 / 3 ASP A 149
ARG A 145
TYR A 146
 NAP  A 301 (-3.2A)
NAP  A 301 (-3.5A)
NAP  A 301 (-4.2A)
 0.71A 5a7mA-5thxA:
3.3		 5a7mA-5thxA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		3 / 3 ASP A 149
ARG A 145
TYR A 146
 NAP  A 301 (-3.2A)
NAP  A 301 (-3.5A)
NAP  A 301 (-4.2A)
 0.73A 5a7mB-5thxA:
undetectable		 5a7mB-5thxA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 8 ILE A 119
LEU A 174
ILE A 138
LEU A 150
 None
 0.88A 5ieoA-5thxA:
undetectable		 5ieoA-5thxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		6 / 9 SER A  54
THR A 117
GLY A 118
ALA A 120
CYH A 219
GLU A 252
 FAD  A 303 (-3.8A)
FAD  A 303 (-3.1A)
None
FAD  A 303 (-3.5A)
None
FAD  A 303 ( 4.0A)
 0.58A 5vw4A-5thxA:
7.7		 5vw4A-5thxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		6 / 9 THR A 117
GLY A 118
ALA A 120
CYH A 219
GLY A 220
GLU A 252
 FAD  A 303 (-3.1A)
None
FAD  A 303 (-3.5A)
None
None
FAD  A 303 ( 4.0A)
 0.66A 5vw4A-5thxA:
7.7		 5vw4A-5thxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 8 SER A  54
THR A 117
GLY A 118
CYH A 219
GLU A 252
 FAD  A 303 (-3.8A)
FAD  A 303 (-3.1A)
None
None
FAD  A 303 ( 4.0A)
 0.58A 5vw5A-5thxA:
20.8		 5vw5A-5thxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 8 THR A 117
GLY A 118
CYH A 219
GLY A 220
GLU A 252
 FAD  A 303 (-3.1A)
None
None
None
FAD  A 303 ( 4.0A)
 0.68A 5vw5A-5thxA:
20.8		 5vw5A-5thxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5thx FERREDOXIN--NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 150
GLY A 116
ALA A 151
PHE A 255
THR A 115
 None
NAP  A 301 ( 3.9A)
None
FAD  A 303 (-3.4A)
NAP  A 301 (-3.5A)
 1.33A 5x6yC-5thxA:
undetectable		 5x6yC-5thxA:
15.59