SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ti8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 11 ILE A 338
LEU A  73
LEU A 292
GLY A 291
ALA A 330
 None
 1.10A 1b02A-5ti8A:
undetectable		 1b02A-5ti8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 10 ARG A 442
ALA A 366
LEU A 383
ALA A 374
GLY A 376
 None
 1.33A 1mjqG-5ti8A:
undetectable
1mjqH-5ti8A:
undetectable		 1mjqG-5ti8A:
12.91
1mjqH-5ti8A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 12 ALA A 260
ASP A 261
ILE A 303
ILE A 288
GLY A 266
 None
 1.00A 1sguB-5ti8A:
undetectable		 1sguB-5ti8A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 5 LEU A  46
ASP A  56
GLY A 295
ALA A  41
 None
 0.95A 2aohA-5ti8A:
undetectable		 2aohA-5ti8A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 7 GLY A 300
PHE A 267
ILE A 105
PHE A 274
 None
 0.95A 2qmzA-5ti8A:
undetectable
2qmzB-5ti8A:
undetectable		 2qmzA-5ti8A:
18.99
2qmzB-5ti8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 12 ILE A 237
ALA A 374
VAL A 371
MET A 421
ARG A 394
 None
 1.30A 2qo4A-5ti8A:
undetectable		 2qo4A-5ti8A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 9 LEU A 445
PRO A 369
LEU A 453
ALA A 452
PHE A 395
 None
 1.24A 2vcvD-5ti8A:
undetectable		 2vcvD-5ti8A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 6 MET A 414
PRO A 425
ILE A 422
LEU A 383
 None
 1.19A 2wekB-5ti8A:
undetectable		 2wekB-5ti8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 12 ILE A 434
LEU A 358
ILE A 423
VAL A  44
LEU A  55
 None
 1.14A 3a51D-5ti8A:
undetectable		 3a51D-5ti8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		3 / 3 TRP A 362
VAL A  44
ARG A  70
 None
 0.81A 3b0wA-5ti8A:
undetectable		 3b0wA-5ti8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 11 GLU A 336
ILE A 338
GLU A 343
ASP A 107
ALA A 104
 None
 1.00A 3dxyA-5ti8A:
undetectable		 3dxyA-5ti8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 12 GLY A 234
GLY A 235
GLN A 231
VAL A 236
ARG A 151
 None
 1.22A 3h52B-5ti8A:
undetectable		 3h52B-5ti8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		3 / 3 LEU A 130
MET A 132
ASP A 284
 None
 0.64A 3v5wA-5ti8A:
undetectable		 3v5wA-5ti8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 11 ALA A  98
VAL A 116
PRO A 110
PHE A 274
ILE A 108
 None
 1.30A 4j4vA-5ti8A:
undetectable		 4j4vA-5ti8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 11 ALA A  98
VAL A 116
PRO A 110
PHE A 274
ILE A 108
 None
 1.33A 4j4vD-5ti8A:
undetectable
4j4vE-5ti8A:
undetectable		 4j4vD-5ti8A:
18.78
4j4vE-5ti8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 6 GLU A 343
GLU A 344
GLU A 336
GLU A  72
 None
 1.34A 4mi4A-5ti8A:
undetectable		 4mi4A-5ti8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 7 GLU A 343
GLU A 344
GLU A 336
GLU A  72
 None
 1.30A 4mj8C-5ti8A:
undetectable		 4mj8C-5ti8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 6 GLU A 433
ASP A  56
ASN A  65
ARG A 269
 None
 1.15A 4ntxA-5ti8A:
undetectable
4ntxC-5ti8A:
undetectable		 4ntxA-5ti8A:
21.84
4ntxC-5ti8A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 12 ALA A 289
GLY A 122
SER A 123
ILE A 264
GLY A 266
 None
 1.19A 4obwA-5ti8A:
undetectable		 4obwA-5ti8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 7 GLU A 343
GLU A 344
GLU A 336
GLU A  72
 None
 1.23A 4r87I-5ti8A:
undetectable		 4r87I-5ti8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 5 LEU A 292
PHE A 274
ILE A 338
ILE A 108
 None
 1.03A 5dzk4-5ti8A:
undetectable
5dzkg-5ti8A:
2.4
5dzkm-5ti8A:
1.8
5dzkn-5ti8A:
undetectable		 5dzk4-5ti8A:
0.21
5dzkg-5ti8A:
20.42
5dzkm-5ti8A:
19.79
5dzkn-5ti8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 11 ILE A 338
LEU A  73
LEU A 292
GLY A 291
ALA A 330
 None
 1.17A 5fctA-5ti8A:
undetectable		 5fctA-5ti8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 5 GLY A 398
ARG A 394
MET A 414
MET A  58
 None
 1.40A 5gwkA-5ti8A:
undetectable		 5gwkA-5ti8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		3 / 3 ILE A 179
PRO A 180
ILE A 182
 None
 0.27A 5hw8F-5ti8A:
undetectable		 5hw8F-5ti8A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 7 GLN A 359
GLY A 381
ILE A 230
GLN A 187
 None
 1.02A 5vlmC-5ti8A:
undetectable		 5vlmC-5ti8A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 8 GLN A 359
GLY A 381
ILE A 230
GLN A 187
 None
 1.06A 5vlmD-5ti8A:
undetectable		 5vlmD-5ti8A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 8 TYR A 278
ILE A 230
LEU A 358
ALA A 355
 None
 0.81A 5y7pC-5ti8A:
undetectable		 5y7pC-5ti8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		4 / 7 GLY A 295
TYR A 296
GLU A  42
GLY A  69
 None
 0.84A 6n7fA-5ti8A:
undetectable		 6n7fA-5ti8A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5ti8 AMINOTRANSFERASE
(Pseudomonas
sp.
M1) 		5 / 12 ILE A 338
LEU A  73
LEU A 292
GLY A 291
ALA A 330
 None
 1.07A 6r2eH-5ti8A:
undetectable		 6r2eH-5ti8A:
22.13