SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tic'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5tic ACYL-COA
THIOESTERASE I
(Escherichia
coli) 		4 / 5 LEU A  88
SER A  10
LEU A  11
GLY A  71
 None
 1.09A 1a4lB-5ticA:
2.8		 1a4lB-5ticA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 5tic ACYL-COA
THIOESTERASE I
(Escherichia
coli) 		4 / 7 MET A 105
GLU A  69
LEU A  67
MET A 170
 None
 0.84A 1linA-5ticA:
undetectable		 1linA-5ticA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5tic ACYL-COA
THIOESTERASE I
(Escherichia
coli) 		5 / 11 GLY A  50
GLY A   8
GLY A  71
GLY A  72
ASP A  74
 None
 0.89A 1mxgA-5ticA:
3.4		 1mxgA-5ticA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5tic ACYL-COA
THIOESTERASE I
(Escherichia
coli) 		5 / 12 LEU A  70
LEU A 128
LEU A 136
VAL A 134
LEU A  67
 None
 1.16A 1s9pB-5ticA:
undetectable		 1s9pB-5ticA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 5tic ACYL-COA
THIOESTERASE I
(Escherichia
coli) 		3 / 3 LEU A 109
PRO A 110
ARG A  77
 None
 0.66A 2qd5A-5ticA:
5.7		 2qd5A-5ticA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 5tic ACYL-COA
THIOESTERASE I
(Escherichia
coli) 		6 / 11 ASP A  74
GLY A  71
ASP A   9
ILE A  42
GLY A  50
LEU A  51
 None
 1.23A 3em4U-5ticA:
undetectable		 3em4U-5ticA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tic ACYL-COA
THIOESTERASE I
(Escherichia
coli) 		5 / 12 HIS A 157
ASP A 154
LEU A  76
ASN A  73
GLY A  44
 None
 1.49A 4pgfA-5ticA:
2.2		 4pgfA-5ticA:
18.31