SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		4 / 6 LEU A 133
PHE A 182
ILE A 126
ALA A 129
 None
 0.81A 2j5mA-5tiiA:
undetectable		 2j5mA-5tiiA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 10 ILE A 126
PHE A  78
TYR A 175
LEU A 133
LEU A  88
 None
 1.49A 2w98A-5tiiA:
9.1		 2w98A-5tiiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A 121
ALA A 122
ILE A 142
GLY A  96
VAL A  97
 None
 0.84A 3cyxA-5tiiA:
undetectable		 3cyxA-5tiiA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A 188
GLY A 150
SER A 147
ARG A 165
ILE A 151
 None
 1.09A 3k13B-5tiiA:
2.5		 3k13B-5tiiA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A 188
GLY A 150
SER A 147
ARG A 165
ILE A 151
 None
 1.08A 3k13C-5tiiA:
3.0		 3k13C-5tiiA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A  17
ALA A 226
LEU A  13
PHE A  37
LEU A  29
 None
 1.06A 3p2kA-5tiiA:
5.9		 3p2kA-5tiiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		3 / 3 ARG A  52
ARG A  23
ASP A  45
 None
 0.98A 3wipG-5tiiA:
undetectable
3wipH-5tiiA:
undetectable		 3wipG-5tiiA:
18.95
3wipH-5tiiA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  92
VAL A 225
GLY A 227
ALA A 226
LEU A  29
 None
 1.16A 4coxA-5tiiA:
undetectable		 4coxA-5tiiA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  92
VAL A 225
GLY A 227
ALA A 226
LEU A  29
 None
 1.14A 4coxB-5tiiA:
undetectable		 4coxB-5tiiA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  92
VAL A 225
GLY A 227
ALA A 226
LEU A  29
 None
 1.15A 4coxC-5tiiA:
undetectable		 4coxC-5tiiA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  92
VAL A 225
GLY A 227
ALA A 226
LEU A  29
 None
 1.16A 4coxD-5tiiA:
undetectable		 4coxD-5tiiA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A  22
GLY A  20
ILE A 142
LEU A  27
VAL A  25
 None
 1.00A 4qdjA-5tiiA:
7.1		 4qdjA-5tiiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  92
VAL A 225
GLY A 227
ALA A 226
LEU A  29
 None
 1.11A 4rrwA-5tiiA:
undetectable		 4rrwA-5tiiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  92
VAL A 225
GLY A 227
ALA A 226
LEU A  29
 None
 1.12A 4rrwB-5tiiA:
undetectable		 4rrwB-5tiiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  92
VAL A 225
GLY A 227
ALA A 226
LEU A  29
 None
 1.10A 4rrxA-5tiiA:
undetectable		 4rrxA-5tiiA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  92
VAL A 225
GLY A 227
ALA A 226
LEU A  29
 None
 1.10A 4rrxB-5tiiA:
undetectable		 4rrxB-5tiiA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  92
VAL A 225
GLY A 227
ALA A 226
LEU A  29
 None
 1.11A 4rrzA-5tiiA:
undetectable		 4rrzA-5tiiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  92
VAL A 225
GLY A 227
ALA A 226
LEU A  29
 None
 1.12A 4rrzB-5tiiA:
undetectable		 4rrzB-5tiiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		3 / 3 TRP A 231
ILE A 140
SER A 138
 None
 0.87A 5gqbA-5tiiA:
3.5		 5gqbA-5tiiA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A 188
GLY A 150
SER A 147
ARG A 165
ILE A 151
 None
 1.13A 5vooA-5tiiA:
2.4		 5vooA-5tiiA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A 188
GLY A 150
SER A 147
ARG A 165
ILE A 151
 None
 1.10A 5vooC-5tiiA:
2.9		 5vooC-5tiiA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A 188
GLY A 150
SER A 147
ARG A 165
ILE A 151
 None
 1.08A 5vooE-5tiiA:
3.2		 5vooE-5tiiA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A 188
GLY A 150
SER A 147
ARG A 165
ILE A 151
 None
 1.10A 5vooF-5tiiA:
3.1		 5vooF-5tiiA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A 188
GLY A 150
SER A 147
ARG A 165
ILE A 151
 None
 1.08A 5vopB-5tiiA:
2.8		 5vopB-5tiiA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		4 / 6 GLU A  43
TYR A  40
GLY A  17
GLY A  22
 None
 0.95A 5x7pB-5tiiA:
undetectable		 5x7pB-5tiiA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		4 / 7 VAL A  26
LEU A 124
PHE A  37
LEU A  77
 None
 1.00A 6aycA-5tiiA:
undetectable		 6aycA-5tiiA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		4 / 7 ARG A 113
ARG A  41
LEU A  68
ALA A 122
 None
 0.91A 6b89A-5tiiA:
undetectable		 6b89A-5tiiA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5tii 3-OXOACYL-ACP
REDUCTASE
(uncultured
bacterium) 		4 / 8 LEU A   7
VAL A  34
VAL A  92
VAL A  14
 None
 1.10A 6cp4A-5tiiA:
undetectable		 6cp4A-5tiiA:
21.87