SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tiz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		3 / 3 ASP A 179
PHE A 161
ASN A 172
 None
 0.76A 1sg9B-5tizA:
undetectable		 1sg9B-5tizA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		5 / 11 TYR A  47
GLN A  53
ILE A  41
TYR A  36
VAL A  85
 None
 1.44A 2vcdA-5tizA:
undetectable		 2vcdA-5tizA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		4 / 6 TRP A  52
ASN A  80
TYR A  36
TYR A  82
 None
 1.45A 4f8yA-5tizA:
undetectable
4f8yB-5tizA:
undetectable		 4f8yA-5tizA:
22.34
4f8yB-5tizA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		4 / 6 TRP A  52
TYR A  36
TYR A  82
LEU A  79
 None
 1.44A 4f8yA-5tizA:
undetectable
4f8yB-5tizA:
undetectable		 4f8yA-5tizA:
22.34
4f8yB-5tizA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		4 / 5 TRP A  52
TYR A  36
TYR A  82
LEU A  79
 None
 1.43A 4f8yC-5tizA:
undetectable
4f8yD-5tizA:
undetectable		 4f8yC-5tizA:
22.34
4f8yD-5tizA:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		7 / 12 PRO A  16
HIS A  37
MET A  38
LEU A  88
VAL A 124
PHE A 149
THR A 233
 None
 0.59A 4mubA-5tizA:
35.1		 4mubA-5tizA:
57.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		4 / 7 VAL A 196
GLN A 186
LEU A 194
SER A 191
 None
 1.06A 4zphA-5tizA:
undetectable
4zphB-5tizA:
undetectable		 4zphA-5tizA:
17.48
4zphB-5tizA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		7 / 12 HIS A  37
MET A  38
ILE A  42
LEU A  88
VAL A 124
PHE A 149
THR A 233
 None
 0.55A 5byjA-5tizA:
35.3		 5byjA-5tizA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		6 / 12 HIS A  37
MET A  38
ILE A  42
VAL A 124
LEU A 232
THR A 233
 None
 0.53A 5byjA-5tizA:
35.3		 5byjA-5tizA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		5 / 12 HIS A  37
MET A  38
ILE A  42
VAL A 229
LEU A 143
 None
 1.21A 5bykA-5tizA:
35.3		 5bykA-5tizA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		6 / 12 PRO A  16
HIS A  37
LEU A  88
VAL A 123
VAL A 124
THR A 230
 None
 1.39A 5bykA-5tizA:
35.3		 5bykA-5tizA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		10 / 12 PRO A  16
HIS A  37
MET A  38
ILE A  42
LEU A  88
VAL A 123
VAL A 124
LEU A 143
PHE A 149
THR A 233
 None
 0.57A 5bykA-5tizA:
35.3		 5bykA-5tizA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		10 / 12 PRO A  16
MET A  38
ILE A  42
LEU A  88
VAL A 123
VAL A 124
LEU A 143
PHE A 149
THR A 233
LEU A 236
 None
 0.61A 5tiwA-5tizA:
35.9		 5tiwA-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		8 / 12 PRO A  16
MET A  38
LEU A  88
VAL A 123
LEU A 143
LEU A 232
THR A 233
LEU A 236
 None
 0.62A 5tiwA-5tizA:
35.9		 5tiwA-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		5 / 12 PRO A  16
ASP A  87
LEU A  88
SER A 156
LEU A 143
 None
 1.22A 5tiwB-5tizA:
35.7		 5tiwB-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		5 / 12 PRO A  16
MET A  38
ASP A  87
LEU A  88
SER A 156
 None
 1.17A 5tiwB-5tizA:
35.7		 5tiwB-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		8 / 12 PRO A  16
MET A  38
ILE A  42
ASP A  87
LEU A  88
VAL A 124
LEU A 232
THR A 233
 None
 0.66A 5tiwB-5tizA:
35.7		 5tiwB-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		8 / 12 PRO A  16
MET A  38
ILE A  42
ASP A  87
LEU A  88
VAL A 124
PHE A 149
THR A 233
 None
 0.67A 5tiwB-5tizA:
35.7		 5tiwB-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		6 / 9 PRO A  16
MET A  38
LEU A  88
VAL A 124
LEU A 125
PHE A 149
 None
 0.66A 5tixA-5tizA:
36.1		 5tixA-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		7 / 10 PRO A  16
MET A  38
ILE A  42
LEU A  88
VAL A 124
LEU A 125
PHE A 149
 None
 0.62A 5tixB-5tizA:
36.0		 5tixB-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		7 / 11 PRO A  16
MET A  38
ILE A  42
ASP A  87
VAL A 124
LEU A 232
THR A 233
 None
 0.61A 5tiyA-5tizA:
35.8		 5tiyA-5tizA:
61.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		7 / 11 PRO A  16
MET A  38
ILE A  42
ASP A  87
VAL A 124
PHE A 149
THR A 233
 None
 0.66A 5tiyA-5tizA:
35.8		 5tiyA-5tizA:
61.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		4 / 6 GLY A  92
THR A 160
GLN A 162
TYR A  94
 None
 1.20A 6ag0C-5tizA:
undetectable		 6ag0C-5tizA:
14.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B4Y_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		7 / 10 MET A  38
ILE A  42
ASP A  87
LEU A  88
VAL A 124
PHE A 149
THR A 233
 None
 0.61A 6b4yA-5tizA:
35.2		 6b4yA-5tizA:
58.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		6 / 12 PRO A  16
HIS A  37
ASP A  87
VAL A 123
VAL A 124
THR A 230
 None
 1.26A 6b50A-5tizA:
35.2		 6b50A-5tizA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		9 / 12 PRO A  16
HIS A  37
MET A  38
ASP A  87
LEU A  88
VAL A 123
VAL A 124
PHE A 149
THR A 233
 None
 0.52A 6b50A-5tizA:
35.2		 6b50A-5tizA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		9 / 12 PRO A  16
MET A  38
ILE A  42
LEU A  88
VAL A 123
VAL A 124
LEU A 143
LEU A 232
THR A 233
 None
 0.73A 6b52A-5tizA:
35.8		 6b52A-5tizA:
60.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		9 / 12 PRO A  16
MET A  38
ILE A  42
LEU A  88
VAL A 123
VAL A 124
LEU A 143
PHE A 149
THR A 233
 None
 0.69A 6b52A-5tizA:
35.8		 6b52A-5tizA:
60.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		9 / 12 MET A  38
ILE A  42
ASP A  87
LEU A  88
VAL A 124
LEU A 143
PHE A 149
THR A 233
LEU A 236
 None
 0.72A 6b54A-5tizA:
35.5		 6b54A-5tizA:
61.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		4 / 4 LEU A  56
ASP A  57
GLN A  60
VAL A 123
 None
 1.24A 6bzoF-5tizA:
undetectable		 6bzoF-5tizA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		4 / 8 ILE A  68
GLN A  72
ILE A  58
THR A  54
 None
 1.07A 6cduG-5tizA:
undetectable
6cduH-5tizA:
undetectable		 6cduG-5tizA:
21.83
6cduH-5tizA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5tiz SULFOTRANSFERASE
(Schistosoma
japonicum) 		4 / 5 ILE A  42
LEU A  43
THR A  20
LEU A  21
 None
None
A3P  A 301 (-2.5A)
A3P  A 301 (-4.2A)
 0.90A 6nmpN-5tizA:
undetectable
6nmpW-5tizA:
undetectable		 6nmpN-5tizA:
17.49
6nmpW-5tizA:
16.37