SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tj2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TRP A 158
VAL A 259
TRP A 340
 None
None
MAL  A1501 (-3.8A)
 1.29A 1c4dA-5tj2A:
undetectable
1c4dB-5tj2A:
undetectable		 1c4dA-5tj2A:
1.89
1c4dB-5tj2A:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL A   8
VAL A  50
ILE A  60
ASN A 267
 None
 0.92A 1e06A-5tj2A:
undetectable		 1e06A-5tj2A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		6 / 9 ALA A 276
ILE A   9
VAL A  35
ILE A   2
ILE A  60
ILE A  59
 None
 1.45A 1hshB-5tj2A:
undetectable		 1hshB-5tj2A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 GLU A 111
TRP A 230
LYS A 273
 MAL  A1501 (-3.0A)
MAL  A1501 ( 4.6A)
None
 1.20A 1qu2A-5tj2A:
undetectable		 1qu2A-5tj2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 GLU A 310
TYR A 307
ASP A 314
ARG A 316
 None
 1.48A 2a3bB-5tj2A:
undetectable		 2a3bB-5tj2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 THR A  93
GLN A 325
ALA A 324
ALA A 303
ALA A 301
 None
 1.15A 2f16H-5tj2A:
undetectable
2f16I-5tj2A:
undetectable		 2f16H-5tj2A:
19.20
2f16I-5tj2A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 THR A  93
GLN A 325
ALA A 324
ALA A 303
ALA A 301
 None
 1.14A 2f16V-5tj2A:
undetectable
2f16W-5tj2A:
undetectable		 2f16V-5tj2A:
19.20
2f16W-5tj2A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ARG A1229
LEU A1392
GLN A1343
GLU A1341
 None
 0.97A 2fcnA-5tj2A:
undetectable
2fcnB-5tj2A:
undetectable		 2fcnA-5tj2A:
8.39
2fcnB-5tj2A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
 1.08A 2q6oA-5tj2A:
2.2		 2q6oA-5tj2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MAL  A1501 (-3.0A)
 1.01A 2zw9A-5tj2A:
undetectable		 2zw9A-5tj2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PHE A 258
ALA A 162
LEU A 247
PRO A 159
 None
 0.96A 3bgdA-5tj2A:
undetectable		 3bgdA-5tj2A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.76A 3bjwC-5tj2A:
3.5		 3bjwC-5tj2A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.31A 3gv1A-5tj2A:
undetectable
3gv1C-5tj2A:
undetectable		 3gv1A-5tj2A:
12.84
3gv1C-5tj2A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.29A 3gv1A-5tj2A:
undetectable
3gv1B-5tj2A:
undetectable		 3gv1A-5tj2A:
12.84
3gv1B-5tj2A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 343
GLY A 187
ALA A 188
LEU A 192
LEU A 160
 None
 1.05A 3hs6A-5tj2A:
undetectable		 3hs6A-5tj2A:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		10 / 12 ASP A  14
LYS A  15
GLU A  44
GLU A  45
ALA A  63
ASP A  65
GLU A 111
PRO A 154
TRP A 230
TYR A 341
 MAL  A1501 (-3.2A)
MAL  A1501 (-2.7A)
None
None
MAL  A1501 (-3.5A)
MAL  A1501 (-2.8A)
MAL  A1501 (-3.0A)
MAL  A1501 (-3.6A)
MAL  A1501 ( 4.6A)
None
 0.41A 3jyrA-5tj2A:
61.5		 3jyrA-5tj2A:
85.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		6 / 7 ASN A  12
TRP A  62
GLU A 153
TYR A 155
MET A 330
TRP A 340
 MAL  A1501 (-4.3A)
MAL  A1501 (-4.4A)
MAL  A1501 (-3.5A)
MAL  A1501 (-3.9A)
MAL  A1501 ( 4.5A)
MAL  A1501 (-3.8A)
 0.14A 3jyrA-5tj2A:
61.5		 3jyrA-5tj2A:
85.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LEU A1392
LEU A1358
SER A1364
THR A 345
 None
 1.04A 3lm8B-5tj2A:
undetectable
3lm8D-5tj2A:
undetectable		 3lm8B-5tj2A:
17.15
3lm8D-5tj2A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.00A 3n8yB-5tj2A:
undetectable		 3n8yB-5tj2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ILE A 161
GLN A 365
ALA A 362
LEU A 361
ALA A 162
 None
 1.10A 3ozvB-5tj2A:
undetectable		 3ozvB-5tj2A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A1501 (-3.0A)
None
 0.83A 3tbgB-5tj2A:
undetectable		 3tbgB-5tj2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A1501 (-3.0A)
None
 0.81A 3tbgD-5tj2A:
undetectable		 3tbgD-5tj2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.34A 3vwqA-5tj2A:
undetectable		 3vwqA-5tj2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.34A 3vywD-5tj2A:
undetectable		 3vywD-5tj2A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A1501 (-3.2A)
 0.96A 4n48A-5tj2A:
undetectable		 4n48A-5tj2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.17A 4or0B-5tj2A:
undetectable		 4or0B-5tj2A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 PHE A 169
PHE A1345
GLY A1223
ILE A1226
 None
 0.97A 4qoiA-5tj2A:
undetectable
4qoiB-5tj2A:
undetectable		 4qoiA-5tj2A:
17.94
4qoiB-5tj2A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ASP A1383
LEU A  75
GLY A  74
 None
 0.47A 4xmfA-5tj2A:
undetectable		 4xmfA-5tj2A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A1355
LEU A1399
THR A 366
ALA A 370
LEU A1392
 None
 1.22A 5iepA-5tj2A:
undetectable		 5iepA-5tj2A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A1396
GLU A1348
ALA A 363
THR A 366
 None
 0.66A 5og9A-5tj2A:
undetectable		 5og9A-5tj2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 SER A1397
LEU A1399
GLN A1344
VAL A1346
LEU A1355
 None
 1.28A 5ubbA-5tj2A:
undetectable		 5ubbA-5tj2A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A 155
ASN A 227
LEU A 113
 MAL  A1501 (-3.9A)
None
None
 0.82A 6b58A-5tj2A:
3.3		 6b58A-5tj2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.44A 6bm5A-5tj2A:
undetectable		 6bm5A-5tj2A:
22.06