SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tj5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 5tj5 V-TYPE PROTON ATPASE
SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 749
TRP A 777
TRP A 751
 None
 1.27A 1c4dA-5tj5A:
undetectable
1c4dB-5tj5A:
undetectable		 1c4dA-5tj5A:
5.79
1c4dB-5tj5A:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 5tj5 V-TYPE PROTON ATPASE
SUBUNIT C
(Saccharomyces
cerevisiae) 		5 / 12 GLY E  27
ALA E  28
ILE E  65
GLY E  67
ILE E  21
 None
 0.95A 2o4sA-5tj5E:
undetectable		 2o4sA-5tj5E:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5tj5 V-TYPE PROTON ATPASE
SUBUNIT A
V-TYPE PROTON ATPASE
SUBUNIT E
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 550
ALA L  42
MET L  43
LEU L  46
 None
 0.87A 2wekB-5tj5A:
undetectable		 2wekB-5tj5A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 5tj5 V-TYPE PROTON ATPASE
SUBUNIT C
(Saccharomyces
cerevisiae) 		5 / 12 GLY E  27
ALA E  28
ILE E  65
GLY E  67
ILE E  21
 None
 0.93A 3d1xB-5tj5E:
undetectable		 3d1xB-5tj5E:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 5tj5 V-TYPE PROTON ATPASE
SUBUNIT C
(Saccharomyces
cerevisiae) 		5 / 12 GLY E  27
ALA E  28
ILE E  65
GLY E  67
ILE E  21
 None
 0.99A 3d1zA-5tj5E:
undetectable		 3d1zA-5tj5E:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5tj5 V-TYPE PROTON ATPASE
SUBUNIT C
(Saccharomyces
cerevisiae) 		5 / 12 GLY E 105
GLY E  31
LEU E 102
GLU E 137
ALA E 107
 None
 1.12A 3kkzA-5tj5E:
undetectable		 3kkzA-5tj5E:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5tj5 V-TYPE PROTON ATPASE
SUBUNIT C'
(Saccharomyces
cerevisiae) 		5 / 12 GLY D 113
GLY D  37
LEU D 110
GLU D 145
ALA D 115
 None
 1.11A 3kkzA-5tj5D:
undetectable		 3kkzA-5tj5D:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5tj5 V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT C
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 PHE D 143
VAL D 146
TYR D 150
ILE E  65
 None
 1.22A 5iwuA-5tj5D:
undetectable		 5iwuA-5tj5D:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5tj5 V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT C
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ALA D 108
GLY D 148
LEU D 149
GLY E  61
 None
 0.82A 6nm4A-5tj5D:
undetectable		 6nm4A-5tj5D:
23.50