SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tj6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		5 / 9 PHE A 492
VAL A 987
LEU A1062
PHE A 540
LEU A 950
 None
 1.46A 1wrkA-5tj6A:
undetectable
1wrkB-5tj6A:
undetectable		 1wrkA-5tj6A:
6.70
1wrkB-5tj6A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		5 / 9 PHE A 500
PHE A 492
VAL A 987
LEU A1062
LEU A 950
 None
 1.40A 1wrkA-5tj6A:
undetectable
1wrkB-5tj6A:
undetectable		 1wrkA-5tj6A:
6.70
1wrkB-5tj6A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 6 ASP A 361
GLU A 328
ARG A 329
LYS A 331
 None
MG  A1106 ( 4.9A)
None
None
 1.34A 1yc2A-5tj6A:
3.5
1yc2B-5tj6A:
3.5
1yc2E-5tj6A:
3.4		 1yc2A-5tj6A:
12.15
1yc2B-5tj6A:
12.15
1yc2E-5tj6A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		5 / 12 PHE A 482
LEU A 478
GLN A 448
ALA A 943
PHE A 500
 None
 1.33A 3apwB-5tj6A:
undetectable		 3apwB-5tj6A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		5 / 12 ASP A 709
SER A 710
LEU A 959
THR A 956
VAL A 978
 None
 1.39A 3mbhC-5tj6A:
3.1		 3mbhC-5tj6A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 7 LEU A 798
ILE A 754
VAL A 825
LEU A 745
 None
 0.70A 3r9vA-5tj6A:
3.4
3r9vB-5tj6A:
2.8		 3r9vA-5tj6A:
14.73
3r9vB-5tj6A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		3 / 3 GLY A 521
THR A1045
ASN A 498
 None
 0.61A 3v4tD-5tj6A:
undetectable		 3v4tD-5tj6A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		5 / 12 GLU A1008
LEU A 992
GLY A1001
PHE A1000
VAL A1059
 None
 1.16A 4foxD-5tj6A:
undetectable		 4foxD-5tj6A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		6 / 12 PHE A 492
PHE A 768
ALA A 489
ALA A 988
THR A1063
LEU A 950
 None
 1.46A 4jbtA-5tj6A:
1.0		 4jbtA-5tj6A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		5 / 11 ASN A 794
ARG A 720
LEU A 798
ILE A 800
LEU A 782
 None
 1.48A 4k37B-5tj6A:
undetectable		 4k37B-5tj6A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		5 / 12 ILE A 951
ALA A 955
ALA A 476
LEU A 933
ILE A 947
 None
 0.88A 4kjjA-5tj6A:
undetectable		 4kjjA-5tj6A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 7 THR A 853
ALA A 851
LEU A 847
SER A 846
 None
 1.01A 4pwjB-5tj6A:
undetectable		 4pwjB-5tj6A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		5 / 11 LEU A 203
ALA A 200
THR A 178
ILE A 179
ASP A 175
 None
 1.38A 4uuuA-5tj6A:
undetectable
4uuuB-5tj6A:
undetectable		 4uuuA-5tj6A:
9.72
4uuuB-5tj6A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 6 ASP A 250
ALA A 258
THR A 286
THR A 285
 None
 1.46A 4w5qA-5tj6A:
3.4		 4w5qA-5tj6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 6 ASP A 250
ALA A 258
THR A 286
THR A 285
 None
 1.48A 4w5tA-5tj6A:
3.4		 4w5tA-5tj6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 6 ASP A 250
ALA A 258
THR A 286
THR A 285
 None
 1.48A 4z4fA-5tj6A:
3.4		 4z4fA-5tj6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 5 ASP A 250
ALA A 258
THR A 286
THR A 285
 None
 1.50A 4z4gA-5tj6A:
3.6		 4z4gA-5tj6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 6 LEU A 763
SER A 486
PRO A 490
PHE A 492
 None
 1.19A 5b8iA-5tj6A:
1.5		 5b8iA-5tj6A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 7 THR A 853
ALA A 851
LEU A 847
SER A 846
 None
 1.04A 5bojB-5tj6A:
undetectable		 5bojB-5tj6A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 5 ILE A 297
LEU A 245
GLY A 289
PHE A 292
 None
 0.95A 5kmdC-5tj6A:
8.0
5kmdD-5tj6A:
5.5		 5kmdC-5tj6A:
14.69
5kmdD-5tj6A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		5 / 12 PHE A 768
ALA A 765
TYR A1025
ALA A 920
THR A 952
 None
 1.22A 5tl8A-5tj6A:
undetectable		 5tl8A-5tj6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 4 ILE A 282
LEU A 270
HIS A 243
ALA A 239
 None
 0.99A 6ck2C-5tj6A:
undetectable
6ck2D-5tj6A:
undetectable		 6ck2C-5tj6A:
4.31
6ck2D-5tj6A:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
(Aplysia
californica) 		4 / 7 ASP A 517
ARG A1026
TYR A1042
ASP A1057
 None
 1.30A 6mn5E-5tj6A:
undetectable		 6mn5E-5tj6A:
5.91