SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tj7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		5 / 12 SER A 494
PHE A 495
LEU A 391
LEU A 616
LEU A 745
 None
 1.32A 1p33A-5tj7A:
undetectable		 1p33A-5tj7A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		5 / 12 SER A 494
PHE A 495
LEU A 391
LEU A 616
LEU A 745
 None
 1.43A 1p33C-5tj7A:
undetectable		 1p33C-5tj7A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		3 / 3 CYH A 750
ARG A 389
CYH A 802
 None
 1.48A 1p9gA-5tj7A:
undetectable		 1p9gA-5tj7A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 7 HIS A 618
LEU A 544
MET A 535
ILE A 532
 None
 1.02A 1tuvA-5tj7A:
undetectable		 1tuvA-5tj7A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		3 / 3 PHE A 621
TYR A 499
TYR A 392
 None
 0.94A 1x70B-5tj7A:
undetectable		 1x70B-5tj7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		5 / 11 ILE A 755
VAL A 783
PHE A 779
LEU A 842
ILE A 861
 None
 1.19A 2h42A-5tj7A:
undetectable		 2h42A-5tj7A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		5 / 12 ALA A 723
ASP A 726
LEU A 725
LEU A 578
GLY A 716
 None
 1.07A 2jfaB-5tj7A:
undetectable		 2jfaB-5tj7A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		5 / 11 ALA A 732
LEU A 737
LEU A 749
ILE A 612
PHE A 724
 None
 1.07A 2w9sA-5tj7A:
undetectable		 2w9sA-5tj7A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 SER A 528
PHE A 607
VAL A 571
PHE A 564
 None
 1.23A 2wekA-5tj7A:
undetectable		 2wekA-5tj7A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		3 / 3 ARG A 376
VAL A 366
THR A 353
 None
 0.71A 3cyxA-5tj7A:
undetectable		 3cyxA-5tj7A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 7 TYR A 617
VAL A 519
VAL A 515
ILE A 532
 None
 1.06A 3ms9B-5tj7A:
undetectable		 3ms9B-5tj7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 7 TYR A 617
VAL A 519
VAL A 515
ILE A 532
 None
 1.04A 3mssB-5tj7A:
undetectable		 3mssB-5tj7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 ILE A 608
VAL A 571
THR A 624
ILE A 622
 None
 0.73A 3p4wC-5tj7A:
2.5		 3p4wC-5tj7A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 SER A 528
ILE A 517
TRP A 563
PHE A 564
 None
 1.26A 4cx7A-5tj7A:
undetectable
4cx7B-5tj7A:
undetectable		 4cx7A-5tj7A:
21.56
4cx7B-5tj7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 SER A 528
ILE A 517
TRP A 563
PHE A 564
 None
 1.26A 4cx7C-5tj7A:
undetectable
4cx7D-5tj7A:
undetectable		 4cx7C-5tj7A:
21.56
4cx7D-5tj7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		3 / 3 TYR A 617
ARG A 503
HIS A 507
 None
 1.23A 4fubA-5tj7A:
undetectable		 4fubA-5tj7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		3 / 3 LEU A 725
LYS A 722
THR A 721
 None
 0.58A 4lj0A-5tj7A:
undetectable		 4lj0A-5tj7A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		5 / 11 GLY A 751
CYH A 750
ALA A 615
ILE A 612
LEU A 737
 None
 1.00A 4xumB-5tj7A:
undetectable		 4xumB-5tj7A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 6 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.05A 5dzkB-5tj7A:
undetectable
5dzkP-5tj7A:
undetectable		 5dzkB-5tj7A:
19.46
5dzkP-5tj7A:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.15A 5dzkF-5tj7A:
undetectable
5dzkT-5tj7A:
undetectable		 5dzkF-5tj7A:
19.46
5dzkT-5tj7A:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 6 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.20A 5dzkg-5tj7A:
undetectable
5dzku-5tj7A:
undetectable		 5dzkg-5tj7A:
19.46
5dzku-5tj7A:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		3 / 3 ASP A 600
ASN A 534
GLN A 530
 None
 0.63A 5k7uA-5tj7A:
undetectable		 5k7uA-5tj7A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		4 / 8 ILE A 608
VAL A 571
THR A 624
ILE A 622
 None
 0.79A 5mzrE-5tj7A:
2.7		 5mzrE-5tj7A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		5 / 12 PHE A 626
ILE A 612
PHE A 579
PHE A 525
PHE A 529
 None
 1.41A 5v5zA-5tj7A:
undetectable		 5v5zA-5tj7A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens) 		3 / 3 PHE A 839
ARG A 841
GLN A 819
 None
 1.10A 6g1pB-5tj7A:
undetectable		 6g1pB-5tj7A:
20.34