SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5tja MUCOLIPIN-1
(Homo
sapiens) 		4 / 7 ILE A 260
LEU A 106
PHE A 105
LEU A 137
 None
 0.86A 3adxA-5tjaA:
undetectable		 3adxA-5tjaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5tja MUCOLIPIN-1
(Homo
sapiens) 		5 / 12 TYR A 170
GLY A 173
LEU A 228
PHE A 182
HIS A 267
 None
 1.32A 3pfgA-5tjaA:
2.9		 3pfgA-5tjaA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5tja MUCOLIPIN-1
(Homo
sapiens) 		4 / 5 LEU A 106
ILE A 233
ALA A 128
PHE A 262
 None
 0.96A 4dc3B-5tjaA:
undetectable		 4dc3B-5tjaA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 5tja MUCOLIPIN-1
(Homo
sapiens) 		4 / 6 SER A 274
LEU A 275
TYR A 109
LEU A 106
 None
 0.95A 4wozA-5tjaA:
undetectable
4wozB-5tjaA:
undetectable		 4wozA-5tjaA:
18.91
4wozB-5tjaA:
18.91