SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tjr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		5 / 12 VAL A 265
LEU A 268
ALA A 286
LEU A 255
ILE A 293
 None
 0.87A 1fk6A-5tjrA:
undetectable		 1fk6A-5tjrA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		5 / 12 LEU A  75
VAL A 200
LEU A 171
LEU A 198
LEU A 187
 None
 1.12A 1mx1C-5tjrA:
undetectable		 1mx1C-5tjrA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		6 / 12 LEU A 198
ALA A 191
GLU A 190
LEU A  74
LEU A 156
ILE A 163
 None
 1.34A 1s9pA-5tjrA:
undetectable		 1s9pA-5tjrA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		3 / 3 THR A   2
GLU A  89
HIS A 202
 None
 0.78A 1xwfA-5tjrA:
undetectable		 1xwfA-5tjrA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		3 / 3 THR A   2
GLU A  89
HIS A 202
 None
 0.80A 1xwfB-5tjrA:
2.3		 1xwfB-5tjrA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		3 / 3 THR A   2
GLU A  89
HIS A 202
 None
 0.80A 1xwfC-5tjrA:
2.6		 1xwfC-5tjrA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		3 / 3 THR A   2
GLU A  89
HIS A 202
 None
 0.78A 1xwfD-5tjrA:
3.6		 1xwfD-5tjrA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		4 / 5 LEU A 101
GLY A  91
PRO A 151
ALA A 152
 None
 0.88A 2aohA-5tjrA:
undetectable		 2aohA-5tjrA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		5 / 12 GLU A 175
GLY A 203
ASP A 204
ALA A 207
ALA A 210
 ADP  A 501 (-3.4A)
None
None
None
None
 1.05A 2br4A-5tjrA:
3.8		 2br4A-5tjrA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		5 / 12 GLU A 175
GLY A 203
ASP A 204
ALA A 207
ALA A 210
 ADP  A 501 (-3.4A)
None
None
None
None
 1.06A 2br4B-5tjrA:
undetectable		 2br4B-5tjrA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		5 / 12 GLU A 175
GLY A 203
ASP A 204
ALA A 207
ALA A 210
 ADP  A 501 (-3.4A)
None
None
None
None
 1.02A 2br4F-5tjrA:
3.7		 2br4F-5tjrA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		4 / 4 VAL A  34
LEU A 211
ILE A 170
LEU A 171
 None
 0.89A 2byoA-5tjrA:
undetectable		 2byoA-5tjrA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		5 / 12 LEU A 297
HIS A 252
ALA A 344
PHE A 369
VAL A 285
 None
 1.39A 2g70A-5tjrA:
undetectable		 2g70A-5tjrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		5 / 12 LEU A 297
HIS A 252
ALA A 344
PHE A 369
VAL A 285
 None
 1.35A 2g70B-5tjrA:
undetectable		 2g70B-5tjrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		5 / 12 LEU A 297
HIS A 252
ALA A 344
PHE A 369
VAL A 285
 None
 1.42A 2g72A-5tjrA:
3.0		 2g72A-5tjrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		4 / 4 LEU A 156
GLY A 104
LEU A 101
GLU A 100
 None
 1.10A 3tgvB-5tjrA:
undetectable		 3tgvB-5tjrA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		3 / 3 PRO A 178
ASP A 177
GLU A 175
 None
None
ADP  A 501 (-3.4A)
 0.74A 3v4tC-5tjrA:
undetectable		 3v4tC-5tjrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		4 / 6 GLU A  76
LYS A  72
LYS A 102
GLU A 106
 None
 1.45A 4a7tF-5tjrA:
undetectable		 4a7tF-5tjrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		4 / 8 GLY A  91
ALA A  97
SER A  87
GLU A 100
 None
 0.82A 4hyfB-5tjrA:
undetectable		 4hyfB-5tjrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		5 / 12 LEU A 211
ALA A 143
LEU A 171
ASN A 199
ALA A 207
 None
 0.90A 4x1kA-5tjrA:
undetectable
4x1kB-5tjrA:
undetectable		 4x1kA-5tjrA:
22.82
4x1kB-5tjrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		5 / 12 LEU A 211
ALA A 143
LEU A 171
ASN A 199
ALA A 207
 None
 0.95A 4x20B-5tjrA:
undetectable		 4x20B-5tjrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
AAC) 		4 / 8 ASN A 251
ALA A 282
SER A 284
HIS A 252
 None
 1.05A 5km8A-5tjrA:
undetectable
5km8B-5tjrA:
undetectable		 5km8A-5tjrA:
15.89
5km8B-5tjrA:
15.89