SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tjz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 212
ASP A 210
LEU A 131
LEU A 190
GLY A 189
 None
AE3  A 305 (-3.6A)
None
None
None
 1.49A 1d4fD-5tjzA:
7.1		 1d4fD-5tjzA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.34A 1q23C-5tjzA:
undetectable		 1q23C-5tjzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.30A 1q23F-5tjzA:
undetectable		 1q23F-5tjzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.38A 1q23I-5tjzA:
undetectable		 1q23I-5tjzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.30A 1q23J-5tjzA:
undetectable		 1q23J-5tjzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.30A 1q23L-5tjzA:
undetectable		 1q23L-5tjzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 222
ALA A  22
ALA A  19
VAL A 225
MET A  16
 None
 1.34A 1rbpA-5tjzA:
undetectable		 1rbpA-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 100
VAL A  73
LEU A 241
LEU A 223
ALA A 224
 None
None
None
SO4  A 315 (-3.8A)
None
 1.06A 2egvA-5tjzA:
2.9		 2egvA-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 180
ALA A 126
PHE A 198
ALA A 119
 None
 0.95A 3hrdA-5tjzA:
undetectable
3hrdB-5tjzA:
undetectable		 3hrdA-5tjzA:
12.86
3hrdB-5tjzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  32
LEU A  41
ASN A  61
THR A  97
 None
None
NAP  A 304 ( 4.2A)
EDO  A 310 ( 3.7A)
 1.03A 3lm8B-5tjzA:
2.4
3lm8D-5tjzA:
2.9		 3lm8B-5tjzA:
20.81
3lm8D-5tjzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.27A 3u9fE-5tjzA:
undetectable		 3u9fE-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.24A 3u9fJ-5tjzA:
undetectable
3u9fK-5tjzA:
undetectable		 3u9fJ-5tjzA:
undetectable
3u9fK-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.27A 3u9fK-5tjzA:
undetectable		 3u9fK-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.28A 3u9fR-5tjzA:
undetectable		 3u9fR-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 222
VAL A  20
ALA A 102
PHE A  52
VAL A  12
 None
None
None
NAP  A 304 (-4.7A)
NAP  A 304 (-3.8A)
 1.29A 4nc3A-5tjzA:
undetectable		 4nc3A-5tjzA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A   8
GLY A   7
ILE A  50
GLY A   4
ARG A  18
 None
NAP  A 304 (-3.4A)
None
None
None
 1.30A 4obwD-5tjzA:
2.6		 4obwD-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 228
VAL A  48
ILE A  50
VAL A 225
 None
 0.65A 4xdtA-5tjzA:
undetectable		 4xdtA-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 MET A  59
GLU A  82
ARG A  83
 BEZ  A 302 ( 4.9A)
BEZ  A 302 ( 4.8A)
BEZ  A 302 (-3.4A)
 0.20A 5tjyA-5tjzA:
42.0		 5tjyA-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 MET A  59
GLU A  82
ARG A  83
 BEZ  A 302 ( 4.9A)
BEZ  A 302 ( 4.8A)
BEZ  A 302 (-3.4A)
 0.02A 5tjzA-5tjzA:
43.6		 5tjzA-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 135
HIS A 133
ARG A 214
 None
PDC  A 301 (-4.0A)
None
 1.14A 6b58A-5tjzA:
3.3		 6b58A-5tjzA:
undetectable