SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tkf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		5 / 10 VAL A 188
VAL A 220
ILE A  37
TYR A 194
GLY A 217
 None
 1.47A 13gsA-5tkfA:
undetectable		 13gsA-5tkfA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		5 / 9 VAL A 188
VAL A 220
ILE A  37
TYR A 194
GLY A 217
 None
 1.47A 13gsB-5tkfA:
undetectable		 13gsB-5tkfA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ALA A 101
VAL A 104
TRP A 108
 None
 0.96A 1grmA-5tkfA:
undetectable		 1grmA-5tkfA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ALA A 101
VAL A 104
TRP A 108
 None
 0.96A 1grmB-5tkfA:
undetectable		 1grmB-5tkfA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		5 / 12 ASN A  44
VAL A  46
TYR A 168
GLN A 112
TRP A  65
 None
None
CU  A 308 (-4.9A)
None
None
 1.48A 1h1dA-5tkfA:
undetectable		 1h1dA-5tkfA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ALA A 101
VAL A 104
TRP A 108
 None
 0.87A 1jo3A-5tkfA:
undetectable		 1jo3A-5tkfA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ALA A 101
VAL A 104
TRP A 108
 None
 0.87A 1jo3B-5tkfA:
undetectable		 1jo3B-5tkfA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ALA A 101
VAL A 104
TRP A 108
 None
 0.93A 1jo4A-5tkfA:
undetectable		 1jo4A-5tkfA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ALA A 101
VAL A 104
TRP A 108
 None
 0.93A 1jo4B-5tkfA:
undetectable		 1jo4B-5tkfA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 8 VAL A 201
SER A  83
TYR A 162
TYR A 168
 None
None
None
CU  A 308 (-4.9A)
 1.02A 2y05A-5tkfA:
undetectable
2y05B-5tkfA:
undetectable		 2y05A-5tkfA:
21.66
2y05B-5tkfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 7 ILE A 111
LEU A  92
PHE A 109
THR A 180
 None
 0.97A 3ag2N-5tkfA:
undetectable
3ag2W-5tkfA:
undetectable		 3ag2N-5tkfA:
17.48
3ag2W-5tkfA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 6 PHE A   4
HIS A 134
THR A  62
VAL A  61
 None
 1.22A 3lb3B-5tkfA:
undetectable		 3lb3B-5tkfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 8 ILE A  89
GLU A 152
TYR A 194
PHE A 167
 None
 0.69A 3rqwI-5tkfA:
undetectable
3rqwJ-5tkfA:
undetectable		 3rqwI-5tkfA:
18.71
3rqwJ-5tkfA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		5 / 12 GLY A  19
GLY A  17
LEU A  16
GLU A 170
LEU A 174
 None
 1.18A 3vywA-5tkfA:
undetectable		 3vywA-5tkfA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 7 ILE A  89
GLU A 152
TYR A 194
PHE A 167
 None
 0.63A 4a97H-5tkfA:
undetectable		 4a97H-5tkfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 6 PRO A 216
ILE A  37
TYR A  91
PHE A 190
 None
 1.24A 4g10A-5tkfA:
undetectable		 4g10A-5tkfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 5 HIS A   1
HIS A  84
GLN A 166
TYR A 168
 CU  A 308 (-3.0A)
CU  A 308 (-3.1A)
CU  A 308 (-4.2A)
CU  A 308 (-4.9A)
 0.66A 4gboA-5tkfA:
8.4		 4gboA-5tkfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 5 HIS A   1
HIS A  84
GLN A 166
TYR A 168
 CU  A 308 (-3.0A)
CU  A 308 (-3.1A)
CU  A 308 (-4.2A)
CU  A 308 (-4.9A)
 0.91A 4gboB-5tkfA:
8.5		 4gboB-5tkfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 5 HIS A   1
HIS A 157
GLN A 166
TYR A 168
 CU  A 308 (-3.0A)
None
CU  A 308 (-4.2A)
CU  A 308 (-4.9A)
 0.96A 4gboB-5tkfA:
8.5		 4gboB-5tkfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 TYR A 213
GLY A  86
PRO A  87
 None
 0.71A 4qwpA-5tkfA:
undetectable		 4qwpA-5tkfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 5 HIS A   1
HIS A  84
GLN A 166
TYR A 168
 CU  A 308 (-3.0A)
CU  A 308 (-3.1A)
CU  A 308 (-4.2A)
CU  A 308 (-4.9A)
 0.64A 5uizA-5tkfA:
8.4		 5uizA-5tkfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_B_CUB301_0
(AA10A)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 4 HIS A   1
HIS A  84
GLN A 166
TYR A 168
 CU  A 308 (-3.0A)
CU  A 308 (-3.1A)
CU  A 308 (-4.2A)
CU  A 308 (-4.9A)
 0.90A 5uizB-5tkfA:
8.4		 5uizB-5tkfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_B_CUB301_0
(AA10A)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 4 HIS A   1
HIS A 157
GLN A 166
TYR A 168
 CU  A 308 (-3.0A)
None
CU  A 308 (-4.2A)
CU  A 308 (-4.9A)
 0.97A 5uizB-5tkfA:
8.4		 5uizB-5tkfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		5 / 12 GLY A  73
PRO A  76
ALA A  77
ASP A  74
LYS A 131
 None
 1.14A 5x6yC-5tkfA:
undetectable		 5x6yC-5tkfA:
14.99