SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens) 		3 / 3 ALA A  67
VAL A  59
TRP A  94
 None
 0.85A 1av2A-5tkmA:
undetectable
1av2B-5tkmA:
undetectable		 1av2A-5tkmA:
6.54
1av2B-5tkmA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens) 		3 / 3 TRP A  94
ALA A  67
VAL A  59
 None
 0.76A 1av2C-5tkmA:
undetectable
1av2D-5tkmA:
undetectable		 1av2C-5tkmA:
6.54
1av2D-5tkmA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens) 		3 / 3 MET A  69
LEU A  72
SER A  73
 None
 0.61A 1ee2A-5tkmA:
undetectable		 1ee2A-5tkmA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens) 		3 / 3 ALA A  67
VAL A  59
TRP A  94
 None
 0.83A 1w5uA-5tkmA:
undetectable
1w5uB-5tkmA:
undetectable		 1w5uA-5tkmA:
6.54
1w5uB-5tkmA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens) 		3 / 3 TRP A  94
ALA A  67
VAL A  59
 None
 0.80A 1w5uA-5tkmA:
undetectable
1w5uB-5tkmA:
undetectable		 1w5uA-5tkmA:
6.54
1w5uB-5tkmA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens) 		3 / 3 ALA A  67
VAL A  59
TRP A  94
 None
 0.74A 2izqA-5tkmA:
undetectable
2izqB-5tkmA:
undetectable		 2izqA-5tkmA:
6.54
2izqB-5tkmA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens) 		3 / 3 TRP A  94
ALA A  67
VAL A  59
 None
 0.88A 2izqC-5tkmA:
undetectable
2izqD-5tkmA:
undetectable		 2izqC-5tkmA:
6.54
2izqD-5tkmA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens) 		3 / 3 ASP A 149
THR A  95
PRO A  96
 None
 0.65A 2q64B-5tkmA:
undetectable		 2q64B-5tkmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens) 		3 / 3 TRP A  94
ALA A  67
VAL A  59
 None
 0.95A 3l8lA-5tkmA:
undetectable
3l8lB-5tkmA:
undetectable		 3l8lA-5tkmA:
6.54
3l8lB-5tkmA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens) 		3 / 3 TRP A  94
ALA A  67
VAL A  59
 None
 0.92A 3l8lC-5tkmA:
undetectable
3l8lD-5tkmA:
undetectable		 3l8lC-5tkmA:
6.54
3l8lD-5tkmA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 5tkm DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens) 		5 / 9 LEU A  35
THR A  33
VAL A  92
LEU A 116
ILE A 118
 None
 1.10A 3tbgD-5tkmA:
undetectable		 3tbgD-5tkmA:
18.09