SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5tla UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus) 		4 / 5 ASP A  54
ARG A  44
VAL A  38
THR A  99
 None
 1.12A 3eigA-5tlaA:
undetectable		 3eigA-5tlaA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5tla UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus) 		4 / 6 LYS A  29
ILE A  32
VAL A   7
LEU A   5
 None
 0.96A 4em2A-5tlaA:
undetectable		 4em2A-5tlaA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5tla UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus) 		3 / 3 TYR A  94
LEU A 122
ASP A 131
 None
 0.79A 5zv2B-5tlaA:
undetectable		 5zv2B-5tlaA:
18.44