SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		5 / 11 PHE A  52
LEU A 103
GLY A 104
MET A  94
ALA A  92
 None
 1.28A 1ju6A-5tlcA:
undetectable		 1ju6A-5tlcA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		4 / 8 THR A  93
PHE A  39
MET A  94
LEU A  55
 None
 0.76A 1lhvA-5tlcA:
undetectable		 1lhvA-5tlcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		3 / 3 ASN A 135
TYR A 160
SER A 108
 None
 0.82A 2gvcB-5tlcA:
undetectable		 2gvcB-5tlcA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		3 / 3 ASN A 135
TYR A 160
SER A 108
 None
 0.79A 2gvcE-5tlcA:
undetectable		 2gvcE-5tlcA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		4 / 7 HIS A 156
SER A 231
ASP A 157
ARG A 236
 None
 1.45A 2rk8B-5tlcA:
undetectable		 2rk8B-5tlcA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		4 / 8 ILE A 225
TRP A 174
TRP A 134
PHE A 121
 None
 1.48A 3ccfB-5tlcA:
undetectable		 3ccfB-5tlcA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		5 / 12 GLY A 309
VAL A 308
GLY A  79
HIS A  20
VAL A 372
 None
 1.19A 3f8wB-5tlcA:
undetectable		 3f8wB-5tlcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		5 / 12 LEU A 408
VAL A 416
LEU A  55
PHE A  13
MET A  94
 None
 1.35A 3h52C-5tlcA:
undetectable		 3h52C-5tlcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		4 / 5 LEU A 326
LEU A 310
GLY A 309
GLY A 365
 None
 0.84A 3si7C-5tlcA:
undetectable
3si7D-5tlcA:
undetectable		 3si7C-5tlcA:
22.27
3si7D-5tlcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		4 / 8 VAL A 107
HIS A 116
PHE A 166
PRO A 223
 None
 1.44A 3v35A-5tlcA:
4.8		 3v35A-5tlcA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		3 / 3 ASP A 125
GLU A 222
GLY A 221
 None
 0.68A 3w9tA-5tlcA:
undetectable		 3w9tA-5tlcA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		5 / 12 VAL A 334
LEU A 321
PHE A 330
PHE A 349
VAL A 342
 None
 1.16A 4eckB-5tlcA:
undetectable		 4eckB-5tlcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		3 / 3 TYR A 199
GLY A 211
PRO A 212
 None
 0.61A 4qwpA-5tlcA:
undetectable		 4qwpA-5tlcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		4 / 5 PRO A 114
VAL A 170
GLY A 104
VAL A 136
 None
 0.91A 6ak3B-5tlcA:
undetectable		 6ak3B-5tlcA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		5 / 12 GLY A  60
VAL A 137
GLY A  78
HIS A 316
ASN A 135
 None
 1.18A 6gngA-5tlcA:
undetectable		 6gngA-5tlcA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		5 / 11 ALA A  10
LEU A  47
GLY A 102
SER A 133
ALA A 105
 None
 1.28A 6ieyA-5tlcA:
undetectable
6ieyB-5tlcA:
undetectable		 6ieyA-5tlcA:
23.13
6ieyB-5tlcA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A
(Bacillus
subtilis) 		4 / 6 ARG A 131
SER A 128
ALA A  92
ALA A  44
 None
 1.17A 6ma6A-5tlcA:
undetectable		 6ma6A-5tlcA:
9.71