SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tnu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		3 / 3 VAL A 221
VAL A  89
TRP A  80
 None
 0.97A 1bdwA-5tnuA:
undetectable
1bdwB-5tnuA:
undetectable		 1bdwA-5tnuA:
3.45
1bdwB-5tnuA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		4 / 8 ARG A 268
ALA A 285
PHE A 264
GLU A 293
 None
 1.08A 1dmiA-5tnuA:
undetectable
1dmiB-5tnuA:
undetectable		 1dmiA-5tnuA:
22.77
1dmiB-5tnuA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		4 / 7 VAL A 104
LEU A 170
LEU A  81
VAL A  99
 None
 0.81A 1jgsA-5tnuA:
undetectable		 1jgsA-5tnuA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A 195
GLU A  83
TRP A  80
LEU A 170
 None
GOL  A 518 (-4.6A)
None
None
 1.42A 3k8mA-5tnuA:
undetectable		 3k8mA-5tnuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		5 / 12 TYR A 195
ILE A 149
ALA A 110
THR A 111
ILE A 113
 None
 1.18A 3ndiA-5tnuA:
3.4		 3ndiA-5tnuA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		4 / 8 VAL A 115
TYR A 184
ILE A 113
ILE A 152
 None
 1.06A 4afgD-5tnuA:
undetectable
4afgE-5tnuA:
undetectable		 4afgD-5tnuA:
20.31
4afgE-5tnuA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		4 / 6 PHE A 264
ALA A 294
ALA A 285
LEU A 281
 None
 1.14A 4dtzB-5tnuA:
undetectable		 4dtzB-5tnuA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 205
GLU A 175
TYR A 213
 CL  A 511 ( 3.8A)
None
None
 0.94A 4r29D-5tnuA:
undetectable		 4r29D-5tnuA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		4 / 7 PHE A 168
SER A 193
ALA A 161
LEU A 164
 None
 1.02A 4xk8A-5tnuA:
undetectable		 4xk8A-5tnuA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 170
VAL A 217
LEU A 199
GLY A 198
ILE A 103
 None
 1.24A 5b8hA-5tnuA:
undetectable
5b8hB-5tnuA:
undetectable		 5b8hA-5tnuA:
22.03
5b8hB-5tnuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		3 / 3 GLU A 175
HIS A 178
ARG A 205
 None
None
CL  A 511 ( 3.8A)
 0.92A 5uunA-5tnuA:
undetectable		 5uunA-5tnuA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A 143
GLY A 141
ASP A 144
LEU A 112
GLY A 137
 None
SO4  A 505 ( 4.8A)
None
None
None
 1.07A 5vooB-5tnuA:
undetectable		 5vooB-5tnuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A 143
GLY A 141
ASP A 144
LEU A 112
GLY A 137
 None
SO4  A 505 ( 4.8A)
None
None
None
 1.06A 5vooD-5tnuA:
undetectable		 5vooD-5tnuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A 143
GLY A 141
ASP A 144
LEU A 112
GLY A 137
 None
SO4  A 505 ( 4.8A)
None
None
None
 1.13A 5vooE-5tnuA:
undetectable		 5vooE-5tnuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A 143
GLY A 141
ASP A 144
LEU A 112
GLY A 137
 None
SO4  A 505 ( 4.8A)
None
None
None
 1.09A 5vooF-5tnuA:
undetectable		 5vooF-5tnuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A 143
GLY A 141
ASP A 144
LEU A 112
GLY A 137
 None
SO4  A 505 ( 4.8A)
None
None
None
 1.08A 5vopB-5tnuA:
undetectable		 5vopB-5tnuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		5 / 9 ASP A 333
ILE A 312
SER A 376
SER A 308
THR A 343
 None
 1.42A 6awpA-5tnuA:
undetectable		 6awpA-5tnuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5tnu DNA-DEPENDENT ATPASE
XPBII
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 199
PHE A 173
VAL A 115
LEU A 120
ILE A 121
 None
 1.04A 6ectA-5tnuA:
3.4		 6ectA-5tnuA:
24.41