SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tnv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 8 LEU A  61
ASN A  18
HIS A  25
ALA A  60
None
0.95A 2bnnA-5tnvA:
undetectable
2bnnB-5tnvA:
undetectable
2bnnA-5tnvA:
20.74
2bnnB-5tnvA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 8 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.18A 2obvA-5tnvA:
undetectable
2obvA-5tnvA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 8 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.21A 2p02A-5tnvA:
undetectable
2p02A-5tnvA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 5 GLN A 130
THR A 127
ALA A 125
ARG A  87
None
1.25A 2qhfA-5tnvA:
undetectable
2qhfA-5tnvA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
5 / 12 TYR A 221
GLU A 176
ASN A 206
ARG A 238
VAL A 259
None
None
MG  A 401 ( 4.1A)
None
None
1.45A 3cb8A-5tnvA:
2.6
3cb8A-5tnvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
5 / 12 VAL A 198
ALA A 197
GLU A 158
THR A 120
ILE A 107
None
1.29A 3dl9B-5tnvA:
undetectable
3dl9B-5tnvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
3 / 3 TYR A 175
ASP A 144
ASP A  92
None
1.00A 3ou7B-5tnvA:
undetectable
3ou7B-5tnvA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_A_KANA401_1
(APH(2')-ID)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
5 / 12 SER A  84
ASP A  50
GLU A 173
GLU A 280
TYR A 273
None
None
MG  A 401 (-2.7A)
MG  A 401 (-2.6A)
None
1.45A 4dfuA-5tnvA:
0.2
4dfuA-5tnvA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
5 / 12 LEU A 109
LEU A 106
ILE A  66
SER A  88
THR A  86
None
1.14A 4f4dB-5tnvA:
undetectable
4f4dB-5tnvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
3 / 3 CYH A 290
ASN A  12
LYS A 234
None
None
MG  A 401 ( 3.8A)
1.48A 4k50A-5tnvA:
undetectable
4k50A-5tnvA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 8 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.20A 4kttA-5tnvA:
undetectable
4kttA-5tnvA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 8 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.18A 4ndnA-5tnvA:
undetectable
4ndnA-5tnvA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 7 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.20A 4ndnC-5tnvA:
undetectable
4ndnC-5tnvA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
5 / 12 LEU A 254
TYR A 221
LEU A 204
GLY A 205
ILE A 233
None
1.14A 4o5fA-5tnvA:
undetectable
4o5fB-5tnvA:
1.4
4o5fA-5tnvA:
25.83
4o5fB-5tnvA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 7 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.25A 4odjA-5tnvA:
undetectable
4odjA-5tnvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 6 ASP A 196
ARG A 164
GLY A 167
HIS A 195
None
0.90A 4oltA-5tnvA:
undetectable
4oltA-5tnvA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 6 ASP A 196
ARG A 164
GLY A 167
HIS A 195
None
0.90A 4oltB-5tnvA:
undetectable
4oltB-5tnvA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 6 ARG A 238
PHE A 240
TYR A 247
HIS A 211
None
1.35A 4uciA-5tnvA:
undetectable
4uciA-5tnvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 7 ARG A 238
PHE A 240
TYR A 247
HIS A 211
None
1.40A 4uciB-5tnvA:
undetectable
4uciB-5tnvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
3 / 3 ASP A  28
GLY A  24
ASP A  22
None
0.64A 4xdtA-5tnvA:
undetectable
4xdtA-5tnvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 8 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.21A 5a1iA-5tnvA:
undetectable
5a1iA-5tnvA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 7 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.21A 5a1iA-5tnvA:
undetectable
5a1iA-5tnvA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
5 / 12 TYR A 221
LEU A 204
GLY A 205
ILE A 233
LEU A 254
None
1.12A 5b8hA-5tnvA:
undetectable
5b8hB-5tnvA:
undetectable
5b8hA-5tnvA:
24.86
5b8hB-5tnvA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
5 / 12 LEU A 254
TYR A 221
LEU A 204
GLY A 205
ILE A 233
None
1.12A 5b8hA-5tnvA:
undetectable
5b8hB-5tnvA:
undetectable
5b8hA-5tnvA:
24.86
5b8hB-5tnvA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
5 / 12 PRO A 251
SER A 286
ASP A 203
GLY A 205
TYR A 236
None
None
MG  A 401 (-3.0A)
None
None
1.26A 5eenA-5tnvA:
undetectable
5eenA-5tnvA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
3 / 3 LYS A  27
ASP A  28
ARG A  19
None
0.98A 5jwaA-5tnvA:
undetectable
5jwaH-5tnvA:
undetectable
5jwaA-5tnvA:
21.58
5jwaH-5tnvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
3 / 3 TYR A 282
SER A 284
TRP A 137
None
0.70A 5n8jB-5tnvA:
undetectable
5n8jB-5tnvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
3 / 3 TYR A 282
SER A 284
TRP A 137
None
0.69A 5n8jA-5tnvA:
undetectable
5n8jA-5tnvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
3 / 3 TYR A 282
SER A 284
TRP A 137
None
0.72A 5n8jD-5tnvA:
undetectable
5n8jD-5tnvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
5 / 12 LEU A 151
LEU A 148
GLY A  96
GLY A 121
TYR A 179
None
1.05A 6ce2B-5tnvA:
undetectable
6ce2B-5tnvA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 8 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.21A 6fboA-5tnvA:
undetectable
6fboA-5tnvA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 8 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.20A 6fcdA-5tnvA:
undetectable
6fcdA-5tnvA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacteriu
m
smegmatis)
4 / 7 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.22A 6g6rA-5tnvA:
undetectable
6g6rA-5tnvA:
23.02