SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 GLY A 261
ALA A 198
THR A 258
ILE A 254
 None
 0.70A 1c9sI-5tnxA:
undetectable
1c9sJ-5tnxA:
undetectable		 1c9sI-5tnxA:
11.17
1c9sJ-5tnxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 GLY A 261
ALA A 198
THR A 258
ILE A 254
 None
 0.71A 1c9sU-5tnxA:
undetectable
1c9sV-5tnxA:
undetectable		 1c9sU-5tnxA:
11.17
1c9sV-5tnxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 7 GLY A 261
ALA A 198
THR A 258
ILE A 254
 None
 0.68A 1gtnA-5tnxA:
undetectable
1gtnK-5tnxA:
undetectable		 1gtnA-5tnxA:
11.17
1gtnK-5tnxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 GLY A 261
ALA A 198
THR A 258
ILE A 254
 None
 0.68A 1gtnE-5tnxA:
undetectable
1gtnF-5tnxA:
undetectable		 1gtnE-5tnxA:
11.17
1gtnF-5tnxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 GLY A 261
ALA A 198
THR A 258
ILE A 254
 None
 0.62A 1gtnI-5tnxA:
undetectable
1gtnJ-5tnxA:
undetectable		 1gtnI-5tnxA:
11.17
1gtnJ-5tnxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 4 HIS A 139
ALA A  64
PHE A 142
GLY A 121
 None
 1.29A 1mj2B-5tnxA:
undetectable		 1mj2B-5tnxA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 4 HIS A 139
ALA A  64
PHE A 142
GLY A 121
 None
 1.24A 1mj2D-5tnxA:
undetectable		 1mj2D-5tnxA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 4 HIS A 139
ALA A  64
PHE A 142
GLY A 121
 None
 1.29A 1mjoB-5tnxA:
undetectable		 1mjoB-5tnxA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 4 HIS A 139
ALA A  64
PHE A 142
GLY A 121
 None
 1.31A 1mjoA-5tnxA:
undetectable		 1mjoA-5tnxA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 4 HIS A 139
ALA A  64
PHE A 142
GLY A 121
 None
 1.28A 1mjoD-5tnxA:
undetectable		 1mjoD-5tnxA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 GLY A 261
ALA A 198
THR A 258
ILE A 254
 None
 0.66A 1utdI-5tnxA:
undetectable
1utdJ-5tnxA:
undetectable		 1utdI-5tnxA:
11.17
1utdJ-5tnxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 10 LEU A 266
SER A 199
PHE A 197
ALA A 182
ALA A 212
 None
 1.45A 1wygA-5tnxA:
undetectable		 1wygA-5tnxA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 5 VAL A 210
SER A 268
VAL A 205
SER A 199
 None
None
CIT  A 401 (-3.7A)
None
 1.39A 2j9cA-5tnxA:
undetectable
2j9cB-5tnxA:
undetectable
2j9cC-5tnxA:
undetectable		 2j9cA-5tnxA:
16.25
2j9cB-5tnxA:
16.25
2j9cC-5tnxA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 LEU A 371
TYR A 349
GLN A 353
 None
 0.71A 2wekA-5tnxA:
32.2		 2wekA-5tnxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 THR A  44
SER A 147
PHE A  22
 None
 0.75A 3d4sA-5tnxA:
undetectable		 3d4sA-5tnxA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 SER A 268
THR A 269
PHE A 197
ILE A 222
ARG A 230
 None
EDO  A 403 ( 4.2A)
None
None
None
 1.18A 3iv6D-5tnxA:
7.7		 3iv6D-5tnxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 PHE A 143
CYH A 176
HIS A  68
 None
 0.83A 3u9fF-5tnxA:
undetectable		 3u9fF-5tnxA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 PHE A 143
CYH A 176
HIS A  68
 None
 0.90A 3u9fG-5tnxA:
undetectable		 3u9fG-5tnxA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 PHE A 143
CYH A 176
HIS A  68
 None
 0.89A 3u9fL-5tnxA:
undetectable		 3u9fL-5tnxA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 PHE A 143
CYH A 176
HIS A  68
 None
 0.85A 3u9fS-5tnxA:
undetectable		 3u9fS-5tnxA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 GLY A 203
GLY A 201
MET A 207
VAL A 210
 CIT  A 401 (-3.6A)
EDO  A 403 ( 4.8A)
None
None
 0.81A 4c5nC-5tnxA:
7.1		 4c5nC-5tnxA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 LEU A 170
PRO A 173
ALA A 204
LEU A 331
LEU A 334
 None
None
CIT  A 401 (-4.0A)
None
None
 1.07A 4l9qB-5tnxA:
undetectable		 4l9qB-5tnxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 5 TYR A 349
LEU A 373
ASP A  50
VAL A  91
 None
 1.28A 4nkvA-5tnxA:
undetectable		 4nkvA-5tnxA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 PRO A 374
ALA A 152
ALA A  71
GLY A  70
LEU A  92
 None
 0.98A 4oaeA-5tnxA:
undetectable		 4oaeA-5tnxA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.88A 4otyB-5tnxA:
undetectable		 4otyB-5tnxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 11 GLY A 175
ILE A 160
GLY A 183
PHE A 340
PHE A 342
 None
 1.12A 4qoiA-5tnxA:
3.9
4qoiB-5tnxA:
3.9		 4qoiA-5tnxA:
21.99
4qoiB-5tnxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.89A 4rrwA-5tnxA:
undetectable		 4rrwA-5tnxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.87A 4rrwB-5tnxA:
undetectable		 4rrwB-5tnxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.88A 4rrwC-5tnxA:
undetectable		 4rrwC-5tnxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.88A 4rrwD-5tnxA:
0.2		 4rrwD-5tnxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.86A 4rrxA-5tnxA:
undetectable		 4rrxA-5tnxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.89A 4rrxB-5tnxA:
undetectable		 4rrxB-5tnxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.89A 4rrzA-5tnxA:
undetectable		 4rrzA-5tnxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.87A 4rrzB-5tnxA:
undetectable		 4rrzB-5tnxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.88A 4rrzC-5tnxA:
undetectable		 4rrzC-5tnxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.88A 4rrzD-5tnxA:
0.2		 4rrzD-5tnxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 ASP A 140
ARG A 131
PRO A 137
 None
 1.05A 4wanC-5tnxA:
undetectable		 4wanC-5tnxA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 GLY A 183
SER A 322
PHE A 327
ASN A 187
 None
 0.99A 4wryA-5tnxA:
undetectable		 4wryA-5tnxA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 GLY A 183
SER A 322
PHE A 327
ASN A 187
 None
 0.99A 4wrzA-5tnxA:
undetectable		 4wrzA-5tnxA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 7 GLY A 183
SER A 322
PHE A 327
ASN A 187
 None
 0.99A 4ws0A-5tnxA:
undetectable		 4ws0A-5tnxA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 GLY A 183
SER A 322
PHE A 327
ASN A 187
 None
 0.97A 4ws1A-5tnxA:
undetectable		 4ws1A-5tnxA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 7 PHE A 197
SER A 195
ALA A 190
LEU A 189
 None
 1.11A 4xk8A-5tnxA:
undetectable		 4xk8A-5tnxA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 SER A 245
GLU A 267
ASP A 225
 EDO  A 403 (-2.8A)
None
EDO  A 403 ( 4.3A)
 0.86A 4xudA-5tnxA:
6.9		 4xudA-5tnxA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 GLY A 278
SER A 245
ALA A 198
ASP A 280
ALA A 281
 None
EDO  A 403 (-2.8A)
None
None
None
 1.28A 4ymgB-5tnxA:
6.4		 4ymgB-5tnxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 4 ARG A  33
GLY A  34
GLU A  36
 None
 0.58A 4z2dB-5tnxA:
undetectable
4z2dC-5tnxA:
2.3		 4z2dB-5tnxA:
23.18
4z2dC-5tnxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 9 PHE A 197
ALA A 212
VAL A 205
SER A 199
LEU A 266
 None
None
CIT  A 401 (-3.7A)
None
None
 1.29A 4z69A-5tnxA:
undetectable		 4z69A-5tnxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 GLY A  98
CYH A 103
CYH A 100
 ZN  A 400 ( 4.6A)
ZN  A 400 (-2.3A)
ZN  A 400 (-2.3A)
 0.95A 5inzB-5tnxA:
undetectable		 5inzB-5tnxA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 ALA A 184
LEU A 189
ALA A 204
GLY A 206
SER A 199
 None
None
CIT  A 401 (-4.0A)
None
None
 1.28A 5jglA-5tnxA:
8.5		 5jglA-5tnxA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 ASP A  50
GLY A  67
LEU A  92
ALA A 154
ASN A 158
 None
 1.09A 5kbwA-5tnxA:
undetectable		 5kbwA-5tnxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 ASP A  50
GLY A  67
LEU A  92
ALA A 154
ASN A 158
 None
 1.18A 5kc4E-5tnxA:
undetectable		 5kc4E-5tnxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 ASN A 118
PHE A 142
THR A 180
GLY A 177
 None
None
None
CIT  A 401 ( 4.8A)
 0.97A 5nzxA-5tnxA:
2.5		 5nzxA-5tnxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 7 ASN A 118
PHE A 142
THR A 180
GLY A 177
 None
None
None
CIT  A 401 ( 4.8A)
 0.98A 5nzyA-5tnxA:
2.2		 5nzyA-5tnxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 THR A 180
GLU A 319
HIS A  68
 None
 0.66A 5xioA-5tnxA:
3.3		 5xioA-5tnxA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 THR A 180
GLU A 319
HIS A  68
 None
 0.70A 5xiqB-5tnxA:
2.2		 5xiqB-5tnxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 THR A 180
GLU A 319
HIS A  68
 None
 0.76A 5xiqD-5tnxA:
2.1		 5xiqD-5tnxA:
21.69