SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5to3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 9 ASP B 214
ALA B 215
GLU B 217
GLY B 243
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-3.8A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.86A 1bcuH-5to3B:
46.3		 1bcuH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 9 ASP B 214
ALA B 215
SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.31A 1bcuH-5to3B:
46.3		 1bcuH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 9 HIS B  58
TYR B  62
ILE B 194
ASP B 214
SER B 220
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.6A)
 0.40A 1dwcH-5to3B:
44.9		 1dwcH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 9 TYR B  62
ILE B 194
ASP B 214
GLU B 217
GLY B 253
 0G6  B 501 (-3.7A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.8A)
0G6  B 501 (-3.6A)
 1.01A 1dwcH-5to3B:
44.9		 1dwcH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 9 TYR B  62
TRP B  65
ILE B 194
ASP B 214
GLY B 253
 0G6  B 501 (-3.7A)
0G6  B 501 (-4.8A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.6A)
 0.80A 1dwcH-5to3B:
44.9		 1dwcH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		8 / 12 HIS B  58
TYR B  62
LEU B 111
ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
0G6  B 501 ( 3.8A)
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.60A 1etrH-5to3B:
44.1		 1etrH-5to3B:
79.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 TYR B  62
TRP B  65
LEU B 111
ASP B 214
GLY B 243
GLY B 253
 0G6  B 501 (-3.7A)
0G6  B 501 (-4.8A)
0G6  B 501 ( 3.8A)
0G6  B 501 (-2.9A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.73A 1etrH-5to3B:
44.1		 1etrH-5to3B:
79.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 8 ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.32A 1f5lA-5to3B:
35.4		 1f5lA-5to3B:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		4 / 6 ARG B 212
GLY B 250
ASP B 249
TYR B 252
 None
 1.46A 1kf6M-5to3B:
undetectable
1kf6N-5to3B:
undetectable		 1kf6M-5to3B:
20.26
1kf6N-5to3B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 6 ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.25A 1tnlA-5to3B:
34.7		 1tnlA-5to3B:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		4 / 7 ARG B  35
SER B  37
SER B 406
GLU B 408
 None
 1.21A 2c8aA-5to3B:
undetectable		 2c8aA-5to3B:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		4 / 6 ARG B  35
SER B  37
SER B 406
GLU B 408
 None
 1.20A 2c8aC-5to3B:
undetectable		 2c8aC-5to3B:
17.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 11 HIS B 102
ARG B 104
ARG B 113
TRP B 264
VAL B 268
GLY B 274
 None
 0.83A 2h9tH-5to3B:
44.6		 2h9tH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		7 / 11 HIS B 102
PRO B 103
ARG B 104
ARG B 113
TRP B 264
VAL B 268
GLY B 275
 None
 1.19A 2h9tH-5to3B:
44.6		 2h9tH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 11 HIS B 102
PRO B 103
ARG B 104
TRP B 264
LYS B 267
VAL B 268
 None
 0.99A 2h9tH-5to3B:
44.6		 2h9tH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 11 HIS B 102
TRP B 264
VAL B 268
GLN B 271
GLY B 274
 None
 1.22A 2h9tH-5to3B:
44.6		 2h9tH-5to3B:
88.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 6 ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.20A 2otvA-5to3B:
34.8		 2otvA-5to3B:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 GLY B 157
GLY B 221
GLY B 218
THR B  55
LEU B  54
VAL B  31
 None
None
0G6  B 501 (-3.9A)
None
None
None
 1.29A 2oxtD-5to3B:
undetectable		 2oxtD-5to3B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		7 / 12 ASP B 214
ALA B 215
SER B 220
VAL B 240
GLY B 243
GLY B 253
TYR B 255
 0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
None
 0.31A 2p16A-5to3B:
35.7		 2p16A-5to3B:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		4 / 8 MET B 118
LEU B  96
ARG B  35
LEU B  42
 None
 1.02A 2po5A-5to3B:
undetectable		 2po5A-5to3B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		8 / 12 ASP B 214
ALA B 215
SER B 220
VAL B 240
GLY B 243
GLY B 245
GLY B 253
TYR B 255
 0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
None
0G6  B 501 (-3.6A)
None
 0.36A 2w26A-5to3B:
35.5		 2w26A-5to3B:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		7 / 11 HIS B 102
PRO B 103
ARG B 104
ARG B 113
TRP B 264
VAL B 268
GLY B 275
 None
 1.41A 3bf6H-5to3B:
45.1		 3bf6H-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 11 HIS B 102
PRO B 103
ARG B 104
TRP B 264
VAL B 268
GLY B 274
 None
 0.99A 3bf6H-5to3B:
45.1		 3bf6H-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 11 HIS B 102
PRO B 103
TRP B 264
LYS B 267
VAL B 268
 None
 1.00A 3bf6H-5to3B:
45.1		 3bf6H-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 11 HIS B 102
PRO B 103
TRP B 264
VAL B 268
GLN B 271
GLY B 274
 None
 1.38A 3bf6H-5to3B:
45.1		 3bf6H-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 11 PRO B 103
ARG B 104
TRP B 264
VAL B 268
GLY B 274
 None
 1.38A 3bf6H-5to3B:
45.1		 3bf6H-5to3B:
88.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 10 ILE B 115
LEU B  33
VAL B  31
VAL B  76
LEU B  96
 None
 1.07A 3gwxA-5to3B:
undetectable		 3gwxA-5to3B:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 11 HIS B  58
LEU B 111
ASP B 214
SER B 220
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 ( 3.8A)
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.38A 3gy3A-5to3B:
16.2		 3gy3A-5to3B:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.75A 3keeA-5to3B:
10.6		 3keeA-5to3B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.76A 3keeB-5to3B:
10.5		 3keeB-5to3B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.79A 3keeC-5to3B:
9.9		 3keeC-5to3B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.75A 3keeD-5to3B:
10.9		 3keeD-5to3B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 LYS B  16
GLY B 222
ILE B 239
ALA B  56
ASP B 219
 None
 1.11A 3nvkI-5to3B:
undetectable		 3nvkI-5to3B:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		4 / 6 SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.25A 3rxfA-5to3B:
17.8		 3rxfA-5to3B:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		4 / 5 ASP B 214
SER B 220
VAL B 240
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.6A)
 0.32A 3rxhA-5to3B:
34.6		 3rxhA-5to3B:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.73A 3sueA-5to3B:
9.8		 3sueA-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.74A 3sueB-5to3B:
10.1		 3sueB-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.76A 3sueC-5to3B:
5.8		 3sueC-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.73A 3sueD-5to3B:
10.1		 3sueD-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.70A 3sufA-5to3B:
4.2		 3sufA-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.75A 3sufB-5to3B:
9.9		 3sufB-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 11 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.82A 3sufC-5to3B:
2.3		 3sufC-5to3B:
16.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
LYS B  67
ASP B 214
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.81A 4hfpB-5to3B:
44.5		 4hfpB-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		7 / 12 HIS B  58
TYR B  62
LEU B 111
ILE B 194
ASP B 214
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.39A 4hfpB-5to3B:
44.5		 4hfpB-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 TYR B  62
TRP B  65
LEU B 111
ILE B 194
GLY B 243
GLY B 253
 0G6  B 501 (-3.7A)
0G6  B 501 (-4.8A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.83A 4hfpB-5to3B:
44.5		 4hfpB-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		8 / 12 HIS B  58
TYR B  62
LEU B 111
ILE B 194
ASP B 214
ALA B 215
VAL B 240
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
None
0G6  B 501 (-3.6A)
 0.40A 4hfpD-5to3B:
44.4		 4hfpD-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 TYR B  62
LEU B 111
ILE B 194
ALA B 215
GLU B 217
VAL B 240
 0G6  B 501 (-3.7A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-3.4A)
0G6  B 501 (-3.8A)
None
 1.37A 4hfpD-5to3B:
44.4		 4hfpD-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		8 / 12 TYR B  62
TRP B  65
LEU B 111
ILE B 194
ASP B 214
ALA B 215
VAL B 240
GLY B 253
 0G6  B 501 (-3.7A)
0G6  B 501 (-4.8A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
None
0G6  B 501 (-3.6A)
 0.52A 4hfpD-5to3B:
44.4		 4hfpD-5to3B:
88.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 10 ALA B  56
THR B  55
ALA B 116
ALA B  57
GLY B 238
THR B 256
 None
 1.49A 4qvyK-5to3B:
undetectable
4qvyL-5to3B:
undetectable		 4qvyK-5to3B:
18.56
4qvyL-5to3B:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 10 ALA B  56
THR B  55
ALA B 116
ALA B  57
GLY B 238
THR B 256
 None
 1.49A 4qvyY-5to3B:
undetectable
4qvyZ-5to3B:
undetectable		 4qvyY-5to3B:
18.56
4qvyZ-5to3B:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 HIS B  58
LEU B 111
ALA B 215
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 ( 3.8A)
0G6  B 501 (-3.4A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.76A 4rn6B-5to3B:
37.7		 4rn6B-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 HIS B  58
TYR B  62
LEU B 111
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.35A 4rn6B-5to3B:
37.7		 4rn6B-5to3B:
88.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 GLY B 222
GLY B 238
VAL B 240
ALA B 215
LEU B 180
GLY B 151
 None
None
None
0G6  B 501 (-3.4A)
None
None
 1.37A 5hieC-5to3B:
undetectable		 5hieC-5to3B:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 11 GLY B 213
ALA B 215
PHE B 201
TYR B 255
VAL B 240
 None
0G6  B 501 (-3.4A)
None
None
None
 1.28A 5hw4B-5to3B:
undetectable		 5hw4B-5to3B:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 GLY B 213
ALA B 215
PHE B 201
TYR B 255
VAL B 240
 None
0G6  B 501 (-3.4A)
None
None
None
 1.22A 5hw4C-5to3B:
undetectable		 5hw4C-5to3B:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		4 / 8 THR B 192
ALA B 242
ASP B 114
SER B 241
 None
0G6  B 501 (-3.4A)
None
None
 0.95A 5l5fY-5to3B:
undetectable
5l5fZ-5to3B:
undetectable		 5l5fY-5to3B:
18.58
5l5fZ-5to3B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.72A 6c2mC-5to3B:
9.7		 6c2mC-5to3B:
11.65