SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tos'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		4 / 6 MET A 324
VAL A 327
LEU A 269
PHE A 265
 None
 1.10A 1x8vA-5tosA:
undetectable		 1x8vA-5tosA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		5 / 12 ALA A 278
GLY A 244
LEU A 268
SER A 264
LEU A 162
 None
 1.36A 3bxoA-5tosA:
undetectable		 3bxoA-5tosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		7 / 11 ALA A 103
VAL A 134
PHE A 152
MET A 153
GLY A 156
LEU A 209
SER A 219
 None
 0.98A 3miyA-5tosA:
22.9		 3miyA-5tosA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		6 / 9 ALA A 103
PHE A 152
MET A 153
GLY A 156
LEU A 209
SER A 219
 None
 0.87A 3miyB-5tosA:
17.3		 3miyB-5tosA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		4 / 5 ILE A 137
SER A  54
LYS A  52
GLY A 138
 None
 1.17A 3tkdB-5tosA:
undetectable		 3tkdB-5tosA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		4 / 5 ILE A 137
SER A  54
LYS A  52
GLY A 138
 None
 1.17A 3tkdA-5tosA:
undetectable		 3tkdA-5tosA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		7 / 12 ALA A 103
LYS A 105
VAL A 134
PHE A 152
MET A 153
GLY A 156
LEU A 209
 None
 0.60A 3ue4A-5tosA:
22.8		 3ue4A-5tosA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		7 / 12 VAL A  81
ALA A 103
LYS A 105
LEU A 148
MET A 153
GLY A 156
LEU A 209
 None
 0.66A 3ug2A-5tosA:
21.1		 3ug2A-5tosA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		6 / 10 ALA A 103
VAL A 134
PHE A 152
GLY A 156
LEU A 209
SER A 219
 None
 0.82A 4ks8A-5tosA:
19.2		 4ks8A-5tosA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		5 / 12 ILE A 199
LYS A 243
TYR A 250
SER A 260
LEU A 256
 None
 1.46A 4qztC-5tosA:
undetectable		 4qztC-5tosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		6 / 11 ALA A 103
LYS A 105
MET A 153
GLY A 156
ASN A 207
LEU A 209
 None
 0.78A 4wa9A-5tosA:
20.6		 4wa9A-5tosA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		7 / 12 VAL A  81
ALA A 103
LYS A 105
MET A 153
GLY A 156
ASN A 207
LEU A 209
 None
 1.09A 4wa9B-5tosA:
18.2		 4wa9B-5tosA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		7 / 12 VAL A  81
ALA A 103
PHE A 152
MET A 153
GLY A 156
ASN A 207
LEU A 209
 None
 0.78A 4wa9B-5tosA:
18.2		 4wa9B-5tosA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		5 / 9 LEU A 290
LEU A 269
LEU A 270
LEU A 332
ALA A 328
 None
 1.06A 5dqfA-5tosA:
undetectable		 5dqfA-5tosA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1
(Arabidopsis
thaliana) 		6 / 12 ALA A 103
VAL A 134
PHE A 152
GLY A 156
ASN A 160
LEU A 209
 None
 0.62A 5te0A-5tosA:
19.7		 5te0A-5tosA:
13.26