SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.17A 1d4fA-5tovA:
15.2		 1d4fA-5tovA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.19A 1d4fD-5tovA:
28.0		 1d4fD-5tovA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		3 / 3 THR A  46
GLU A 139
HIS A 336
 None
 0.81A 1xwfA-5tovA:
38.2		 1xwfA-5tovA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		3 / 3 THR A  46
GLU A 139
HIS A 336
 None
 0.84A 1xwfB-5tovA:
38.5		 1xwfB-5tovA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		3 / 3 THR A  46
GLU A 139
HIS A 336
 None
 0.88A 1xwfC-5tovA:
15.8		 1xwfC-5tovA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		3 / 3 THR A  46
GLU A 139
HIS A 336
 None
 0.83A 1xwfD-5tovA:
38.7		 1xwfD-5tovA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.30A 2zj0B-5tovA:
12.6		 2zj0B-5tovA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.32A 2zj0C-5tovA:
12.1		 2zj0C-5tovA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.27A 3g1uD-5tovA:
14.8		 3g1uD-5tovA:
39.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 GLU A 138
LEU A 147
ILE A 111
LEU A 118
ASP A 117
 None
 1.02A 3gcsA-5tovA:
undetectable		 3gcsA-5tovA:
25.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.29A 3glqA-5tovA:
12.1		 3glqA-5tovA:
35.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.32A 3glqB-5tovA:
28.4		 3glqB-5tovA:
35.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 10 THR A  46
GLY A 335
HIS A 336
MET A 341
PHE A 345
 None
 0.80A 3h9uA-5tovA:
28.8		 3h9uA-5tovA:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 10 THR A  46
GLY A 335
HIS A 336
MET A 341
PHE A 345
 None
 0.82A 3h9uB-5tovA:
14.0		 3h9uB-5tovA:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 10 THR A  46
GLY A 335
HIS A 336
MET A 341
PHE A 345
 None
 0.82A 3h9uC-5tovA:
15.7		 3h9uC-5tovA:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.26A 3n58A-5tovA:
11.5		 3n58A-5tovA:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.27A 3n58C-5tovA:
11.9		 3n58C-5tovA:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.21A 3n58D-5tovA:
11.7		 3n58D-5tovA:
39.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 LEU A 279
GLY A 325
LEU A 294
THR A 190
ILE A 186
 None
 1.49A 4p6xE-5tovA:
undetectable		 4p6xE-5tovA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 LEU A 279
GLY A 325
LEU A 294
THR A 190
ILE A 186
 None
 1.44A 4p6xI-5tovA:
undetectable		 4p6xI-5tovA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 9 LEU A  53
LEU A  42
THR A  46
LEU A  49
ILE A  40
 None
 1.35A 4ubsA-5tovA:
undetectable		 4ubsA-5tovA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 9 LEU A 147
GLY A 143
ILE A 111
SER A  39
LEU A 118
 None
 1.12A 4x3mB-5tovA:
2.2		 4x3mB-5tovA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 9 LEU A 147
ILE A 111
LEU A 118
VAL A 120
THR A 119
 None
 1.22A 4x3mB-5tovA:
2.2		 4x3mB-5tovA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		3 / 3 ALA A 351
TYR A 354
PRO A 159
 None
 0.61A 4zdyA-5tovA:
0.3		 4zdyA-5tovA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 LEU A  18
ASN A  19
ALA A  22
SER A  54
LEU A  53
 None
 0.59A 5mwyA-5tovA:
undetectable		 5mwyA-5tovA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 GLY A 143
VAL A 129
LEU A 130
SER A 137
ILE A 111
 None
 0.98A 5vooE-5tovA:
2.2		 5vooE-5tovA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 GLY A 143
VAL A 129
LEU A 130
SER A 137
ILE A 111
 None
 1.03A 5vooF-5tovA:
undetectable		 5vooF-5tovA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 10 GLY A 203
GLY A 205
GLU A 226
VAL A 227
ASP A 228
 None
 0.27A 6exiA-5tovA:
27.8		 6exiA-5tovA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 10 GLY A 203
GLY A 205
GLU A 226
VAL A 227
ASP A 228
 None
 0.32A 6exiB-5tovA:
12.1		 6exiB-5tovA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 GLY A 203
GLY A 205
GLU A 226
VAL A 227
ASP A 228
 None
 0.30A 6exiC-5tovA:
25.1
6exiD-5tovA:
12.3		 6exiC-5tovA:
13.37
6exiD-5tovA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 GLY A 203
GLY A 205
GLU A 226
VAL A 227
ASP A 228
 None
 0.26A 6exiC-5tovA:
25.1
6exiD-5tovA:
12.3		 6exiC-5tovA:
13.37
6exiD-5tovA:
13.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.29A 6f3nA-5tovA:
28.3		 6f3nA-5tovA:
37.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.21A 6f3nC-5tovA:
28.1		 6f3nC-5tovA:
37.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.29A 6f3nD-5tovA:
25.9		 6f3nD-5tovA:
37.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_C_ADNC501_1
(-)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 HIS A 123
THR A 124
ASP A 113
LEU A 156
LEU A 150
 None
 1.16A 6gbnC-5tovA:
29.9		 6gbnC-5tovA:
41.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5tov ADENOSYLHOMOCYSTEINA
SE
(Thermotoga
maritima) 		5 / 12 LYS A 317
LEU A 313
ALA A 277
MET A 245
LEU A 279
 None
 1.04A 6ie8A-5tovA:
undetectable		 6ie8A-5tovA:
19.76